1961
DOI: 10.1007/bf02156422
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The role of calcium and zinc in the electrical and mechanical responses of frog sartorius muscle

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1963
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Cited by 23 publications
(16 citation statements)
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“…The results are in agreement with Ca and Mg experiments on superficial fibres in whole muscles by Edman & Grieve (1961) and Jenden & Reger (1962 Hodgkin & Horowicz (1960a) found an S-shaped relation between the logarithm of the external potassium concentration in which the fibres recovered after a contracture in 190 mM-K, and the state of the contractile system, tested by a second increase in [K]O. In this section the effect of [Ca]o on this relation, i.e.…”
Section: Resultssupporting
confidence: 91%
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“…The results are in agreement with Ca and Mg experiments on superficial fibres in whole muscles by Edman & Grieve (1961) and Jenden & Reger (1962 Hodgkin & Horowicz (1960a) found an S-shaped relation between the logarithm of the external potassium concentration in which the fibres recovered after a contracture in 190 mM-K, and the state of the contractile system, tested by a second increase in [K]O. In this section the effect of [Ca]o on this relation, i.e.…”
Section: Resultssupporting
confidence: 91%
“…Theoretically, an inactivation of the contractile system at a normal resting potential is possible. However, such a situation was never observed in experiments in which the resting potential was measured with internal electrodes (Edman & Grieve, 1961;Jenden & Reger, 1962;this paper, p. 685 Mg ions can replace Ca, at least for the relatively short times used in the present experiments, but it is uncertain whether they can completely restore a normal resting potential as well as a normal contracture after a depolarization due to a lack of Ca or an increase in [K]0. On whole toe muscles Frank (1962) found that several multivalent cations, including Be, Mg, and Zn, in the absence of Ca can restore the ability to develop tension after an increase in [K]O, but in every case only for a limited time.…”
Section: Discussionmentioning
confidence: 63%
“…Koketsu & Noda, 1962), whether or not calcium was present. DISCUSSION Further confirmation has been obtained of the observation that calcium deprivation can lead to a drastic fall of membrane potential in frog skeletal muscle (Bulbring et al 1956;Ishiko & Sato, 1957;Edman & Grieve, 1961). This occurs somewhat more rapidly when EDTA is present.…”
Section: Resultsmentioning
confidence: 55%
“…Frank (1958), using a paraffin-gap recording technique, reported that the depolarization produced by potassium chloride, and by implication the resting potential, was not affected by calcium depletion in the toe muscle of the frog. It is possible that the toe muscle is different in this respect to the frog sartorius muscle, in which the fall is now well documented (Bulbring et al 1956;Ishiko & Sato, 1957;Edman & Grieve, 1961;Koketsu & Noda, 1962); however, Curtis (1963) has also described a fall of resting potential in the toe muscle, using intracellular microelectrodes.…”
Section: Resultsmentioning
confidence: 99%
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