The Role of Calcitonin Gene-Related Peptide in the Mouse Thymus Revisited

Bulloch, Karen; McEwen, BS; Diwa, A.; Radojcic, Tricia; Hausman, J.

doi:10.1111/j.1749-6632.1994.tb39653.x

Cited by 9 publications

(16 citation statements)

References 18 publications

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“…SP‐/CGRP‐immunoreactive nerve fibres were also found adjacent to mast cells in the capsule, interlobular septum, and at the cortico‐medullary junction (Lorton et al. , 1990; Bulloch et al. , 1991; Müller & Weihe, 1991).…”

Section: Thymusmentioning

confidence: 96%

“…Sparse cells positive for CGRP were seen during the late embryonic period at the cortico‐medullary boundary and in the medulla. The number of these cells increases in adulthood and is reduced in the thymus of aged mice (Bulloch et al. , 1994).…”

Section: Thymusmentioning

confidence: 99%

“…Murine thymocytes express CGRP receptors, the stimulation of which increases cAMP levels (Bulloch et al. , 1994; Kurz, von Gaudecker, Kranz, Krisch & Mentlein, 1995; Bulloch, McEwen, Nordberg, Diwa & Baird, 1998).…”

Section: Neuropeptidesmentioning

confidence: 99%

“…SP binding sites were also found in rat thymocytes (Shigematsu, Saavedra & Kurihara, 1986; Elands, Resink & De Kloet, 1990). CGRP and SP probably represent fundamental physiological regulatory substances playing a critical role in differentiation, maturation and proliferation of thymocytes and are more likely to be implicated in promoting apoptosis in the thymus (Bulloch et al. , 1994, 1995, 1998; Kurz et al.…”

Section: Neuropeptidesmentioning

confidence: 99%

“…Moreover, steroids in interplay with the T‐cell receptor (TCR) trigger, may be involved in T cell differentiation‐related life/death decisions in the thymus (Vacchio, Paradopoulos & Ashwell, 1994). Functional studies indicate that CGRP is a potent inhibitor of concanavalin A (con‐A)‐stimulated proliferation of thymocytes (Bulloch et al. , 1994, 1995, 1998).…”

Section: Neuropeptidesmentioning

confidence: 99%

See 4 more Smart Citations

Autonomic innervation of immune organs and neuroimmune modulation

Mignini

Streccioni

Amenta

2003

Auton Autocoid Pharmacol

183

147

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1. Increasing evidence indicates the occurrence of functional interconnections between immune and nervous systems, although data available on the mechanisms of this bi-directional cross-talking are frequently incomplete and not always focussed on their relevance for neuroimmune modulation. 2. Primary (bone marrow and thymus) and secondary (spleen and lymph nodes) lymphoid organs are supplied with an autonomic (mainly sympathetic) efferent innervation and with an afferent sensory innervation. Anatomical studies have revealed origin, pattern of distribution and targets of nerve fibre populations supplying lymphoid organs. 3. Classic (catecholamines and acetylcholine) and peptide transmitters of neural and non-neural origin are released in the lymphoid microenvironment and contribute to neuroimmune modulation. Neuropeptide Y, substance P, calcitonin gene-related peptide, and vasoactive intestinal peptide represent the neuropeptides most involved in neuroimmune modulation. 4. Immune cells and immune organs express specific receptors for (neuro)transmitters. These receptors have been shown to respond in vivo and/or in vitro to the neural substances and their manipulation can alter immune responses. Changes in immune function can also influence the distribution of nerves and the expression of neural receptors in lymphoid organs. 5. Data on different populations of nerve fibres supplying immune organs and their role in providing a link between nervous and immune systems are reviewed. Anatomical connections between nervous and immune systems represent the structural support of the complex network of immune responses. A detailed knowledge of interactions between nervous and immune systems may represent an important basis for the development of strategies for treating pathologies in which altered neuroimmune cross-talking may be involved.

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Section: Thymusmentioning

confidence: 96%

Section: Thymusmentioning

confidence: 99%

Section: Neuropeptidesmentioning

confidence: 99%

Section: Neuropeptidesmentioning

confidence: 99%

Section: Neuropeptidesmentioning

confidence: 99%

See 3 more Smart Citations

Autonomic innervation of immune organs and neuroimmune modulation

Mignini

Streccioni

Amenta

2003

Auton Autocoid Pharmacol

183

147

View full text Add to dashboard Cite

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Regional Neural Regulation of Immunity: Anatomy and Function

Bulloch

2001

Comprehensive Physiology

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The sections in this article are: The Autonomic Nervous System Overview Central Control Terminal Distribution of Fibers Summary The Neuroendocrine System The Immune System Acute‐Phase Response Innervation of Primary, Secondary, and Tertiary Immune Tissues Primary Immune Tissues Thymus Innervation Secondary Immune Tissues Tertiary Immune Tissues Summary Summary and Conclusions

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