The role of Ca2+ in the generation of spontaneous astrocytic Ca2+ oscillations

Parri, H. Rheinallt; Crunelli, Vincenzo

doi:10.1016/s0306-4522(03)00379-8

Cited by 124 publications

(114 citation statements)

References 41 publications

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“…These data also show that, apart from a small interval of k 5 values, the increase of the rate of extrusion of the intracellular calcium from the astrocyte determines a progressive reduction of the oscillation amplitude. This last fact is in agreement with the experimental results reported in Parri and Crunelli [56] and also with those of Lavrentovich and Hemkin [55] and Sneyd et al [54]. On the contrary, there is an increase of the period of calcium oscillation as the parameter k 5 increases.…”

Section: Dynamical Properties Of the New Model Describing Calcium Dynsupporting

confidence: 93%

“…2a indicates that the amplitude of the oscillations is smaller and that the period exhibits a reduced variability. Moreover, in agreement with the experimental results of Parri and Crunelli [56], the increase of the intracellular calcium level determines a decrease of the period of the calcium oscillations. Effects similar to those already discussed occur when ATP is present (data not shown).…”

Section: Dynamical Properties Of the New Model Describing Calcium Dynsupporting

confidence: 90%

“…Similar results were obtained also by Lavrentovich and Hemkin [55]. Moreover, it was shown experimentally that an increase of the intracellular calcium concentration in the astrocyte promotes the generation of oscillations [56]. Therefore, we start by investigating how the values of the parameter k 5 affect the stability properties of the stationary states of the adopted calcium model.…”

Section: Dynamical Properties Of the New Model Describing Calcium Dynsupporting

confidence: 79%

“…Experimentally, it was shown that the inhibition of this pump by cyclopiazonic acid or by thapsigargin produces a decrease of the amplitude and of the frequency of the calcium oscillations in the astrocyte [56][57][58]. To test whether the model is able to reproduce such results, the simulations were carried out by halving the parameter values describing the rate of the SERCA pump (the adopted value was k 3 = 0.25 s −1 ).…”

Section: Dynamical Properties Of the New Model Describing Calcium Dynmentioning

confidence: 99%

“…Experimentally, it was shown that a reduction of the influx of calcium from the endoplasmic reticulum to the cytoplasm (mediated by the IP 3 receptors) does not promote the emergence of calcium oscillations [56,59]. Therefore, to mimic the experimental conditions, the simulations of the calcium model were performed by adopting a smaller value of the parameter k 2 describing the amplitude of such flux.…”

Section: Dynamical Properties Of the New Model Describing Calcium Dynmentioning

confidence: 99%

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Dynamics of a minimal neural model consisting of an astrocyte, a neuron, and an interneuron

Garbo

2009

J Biol Phys

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In this paper, a biophysical neural network model consisting of a pyramidal neuron, an interneuron, and the astrocyte is studied. The corresponding dynamical properties are mainly investigated by using numerical simulations. The results show that the presence of the adenosine triphosphate and of the interneuron impacts the overall neural activity. It is shown that the fluxes of calcium through the cellular membrane strongly affect the modulation of the neural activity arising from the astrocyte.

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Section: Dynamical Properties Of the New Model Describing Calcium Dynsupporting

confidence: 93%

Section: Dynamical Properties Of the New Model Describing Calcium Dynsupporting

confidence: 90%

Section: Dynamical Properties Of the New Model Describing Calcium Dynsupporting

confidence: 79%

Section: Dynamical Properties Of the New Model Describing Calcium Dynmentioning

confidence: 99%

Section: Dynamical Properties Of the New Model Describing Calcium Dynmentioning

confidence: 99%

See 3 more Smart Citations

Dynamics of a minimal neural model consisting of an astrocyte, a neuron, and an interneuron

Garbo

2009

J Biol Phys

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Astroglia

2013

Glial Physiology and Pathophysiology

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Modulation of interleukin‐6 and matrix metalloproteinase 2 expression in human fibroblast‐like synoviocytes by functional ionotropic glutamate receptors

Flood¹,

Parri²,

Williams³

et al. 2007

Arthritis & Rheumatism

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Objective. Patients with rheumatoid arthritis (RA) have increased concentrations of the amino acid glutamate in synovial fluid. This study was undertaken to determine whether glutamate receptors are expressed in the synovial joint, and to determine whether activation of glutamate receptors on human synoviocytes contributes to RA disease pathology.Methods. Glutamate receptor expression was examined in tissue samples from rat knee joints and in human fibroblast-like synoviocytes (FLS). FLS from 5 RA patients and 1 normal control were used to determine whether a range of glutamate receptor antagonists influenced expression of the proinflammatory cytokine interleukin-6 (IL-6), enzymes involved in matrix degradation and cytokine processing (matrix metalloproteinase 2 [MMP-2] and MMP-9), and the inhibitors of these enzymes (tissue inhibitor of metalloproteinases 1 [TIMP-1] and TIMP-2). IL-6 concentrations were determined by enzyme-linked immunosorbent assay, MMP activity was measured by gelatin zymography, and TIMP activity was determined by reverse zymography. Fluorescence imaging of intracellular calcium concentrations in live RA FLS stimulated with specific antagonists was used to reveal functional activation of glutamate receptors that modulated IL-6 or MMP-2.Results. Ionotropic and metabotropic glutamate receptor subunit mRNA were expressed in the patella, fat pad, and meniscus of the rat knee and in human articular cartilage. Inhibition of N-methyl-D-aspartate (NMDA) receptors in RA FLS increased proMMP-2 release, whereas non-NMDA ionotropic glutamate receptor antagonists reduced IL-6 production by these cells. Stimulation with glutamate, NMDA, or kainate (KA) increased intracellular calcium concentrations in RA FLS, demonstrating functional activation of specific ionotropic glutamate receptors.Conclusion. Our findings indicate that activation of NMDA and KA glutamate receptors on human synoviocytes may contribute to joint destruction by increasing IL-6 expression.

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The role of Ca2+ in the generation of spontaneous astrocytic Ca2+ oscillations

Cited by 124 publications

References 41 publications

Dynamics of a minimal neural model consisting of an astrocyte, a neuron, and an interneuron

Dynamics of a minimal neural model consisting of an astrocyte, a neuron, and an interneuron

Astroglia

Modulation of interleukin‐6 and matrix metalloproteinase 2 expression in human fibroblast‐like synoviocytes by functional ionotropic glutamate receptors

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