The role of C-reactive protein in ischemia/reperfusion injury and preconditioning in a rat model of myocardial infarction

Valtchanova-Matchouganska, A; Gondwe, Mavuto; Nadar, Anand

doi:10.1016/j.lfs.2003.12.029

Cited by 20 publications

(16 citation statements)

References 29 publications

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“…44,45 In an animal model, ischemic conditioning blunted the increase in CRP, induced by myocardial infarction, and was related to the degree of ischemia-reperfusion injury. 46 In a small randomized study, ischemic conditioning induced during PCI for myocardial infarction was associated with reduction in hsCRP as well as a reduction in infarct size. 47 In the current study, we observed an elevation in hsCRP after PCI, with no effect of RIPost on hsCRP or myocardial injury, whether applied to the thigh or the arm.…”

Section: Discussionmentioning

confidence: 99%

Remote Ischemic Postconditioning During Percutaneous Coronary Interventions

Lavi

D'Alfonso

Diamantouros

et al. 2014

Circ: Cardiovascular Interventions

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Background-Remote ischemic preconditioning may result in reduction in infarct size during percutaneous coronary intervention (PCI). It is unclear whether remote ischemic postconditioning (RIPost) will reduce the incidence of myocardial injury after PCI, and whether ischemic conditioning of a larger remote organ (thigh versus arm) would provide further myocardial protection. Methods and Results-We randomized 360 patients presenting with stable or unstable angina (28% of patients) and negative Troponin T at baseline to 3 groups: 2 groups received RIPost (induced by ischemia to upper or lower limb), and a third was the control group. RIPost was applied during PCI immediately after stent deployment, by three 5-minute cycles of blood pressure cuff inflation to >200 mm Hg in the arm or thigh (20 mm Hg in the control) with 5-minute breaks between each cycle. The primary end-point was the proportion of patients with Troponin T levels >3×ULN postprocedure (at 6 or 18-24 hours), where ULN stands for upper limit of normal. A total of 120 patients were randomized to each group. There were no differences in baseline characteristics between the 3 groups. The primary outcome occurred in 30%, 35%, and 35% of the arm, thigh, and control groups, respectively (P=0.64). There were no differences in creatine kinase or high sensitivity C-reactive protein levels after PCI or in the incidence of acute kidney injury between the groups. Conclusions-RIPost during PCI did not reduce the incidence of periprocedural myocardial injury. Similar effect was obtained when remote ischemia was induced to the upper or lower limb. Clinical Trial Registration-URL: http://www.clinicaltrials.gov. Unique identifier: NCT00970827.(Circ Cardiovasc Interv. 2014;7:225-232.)

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Section: Discussionmentioning

confidence: 99%

Remote Ischemic Postconditioning During Percutaneous Coronary Interventions

Lavi

D'Alfonso

Diamantouros

et al. 2014

Circ: Cardiovascular Interventions

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“…Several studies revealed an independent association of high plasma CRP levels with adverse prognosis in acute myocardial infarction patients. Interestingly, preconditioning was found to inhibit post-ischemic CRP increases in a rat model of acute myocardial infarction (Valtchanova-Matchouganska et al, 2004). …”

Section: Implications Of Inflammation For Postoperative Atrial Fibrilmentioning

confidence: 99%

Prevention of Postoperative Atrial Fibrillation: Novel and Safe Strategy Based on the Modulation of the Antioxidant System

Rodrigo¹

2012

Front. Physio.

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Postoperative atrial fibrillation (AF) is the most common arrhythmia following cardiac surgery with extracorporeal circulation. The pathogenesis of postoperative AF is multifactorial. Oxidative stress, caused by the unavoidable ischemia–reperfusion event occurring in this setting, is a major contributory factor. Reactive oxygen species (ROS)-derived effects could result in lipid peroxidation, protein carbonylation, or DNA oxidation of cardiac tissue, thus leading to functional and structural myocardial remodeling. The vulnerability of myocardial tissue to the oxidative challenge is also dependent on the activity of the antioxidant system. High ROS levels, overwhelming this system, should result in deleterious cellular effects, such as the induction of necrosis, apoptosis, or autophagy. Nevertheless, tissue exposure to low to moderate ROS levels could trigger a survival response with a trend to reinforce the antioxidant defense system. Administration of n−3 polyunsaturated fatty acids (PUFA), known to involve a moderate ROS production, is consistent with a diminished vulnerability to the development of postoperative AF. Accordingly, supplementation of n−3 PUFA successfully reduced the incidence of postoperative AF after coronary bypass grafting. This response is due to an up-regulation of antioxidant enzymes, as shown in experimental models. In turn, non-enzymatic antioxidant reinforcement through vitamin C administration prior to cardiac surgery has also reduced the postoperative AF incidence. Therefore, it should be expected that a mixed therapy result in an improvement of the cardioprotective effect by modulating both components of the antioxidant system. We present novel available evidence supporting the hypothesis of an effective prevention of postoperative AF including a two-step therapeutic strategy: n−3 PUFA followed by vitamin C supplementation to patients scheduled for cardiac surgery with extracorporeal circulation. The present study should encourage the design of clinical trials aimed to test the efficacy of this strategy to offer new therapeutic opportunities to patients challenged by ischemia–reperfusion events not solely in heart, but also in other organs such as kidney or liver in transplantation surgeries.

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“…23 Elevated CRP levels were reported to be associated with a larger SIA. 30 We found that the levels of cTnT and hsCRP were similar in the infarct size groups, and were not correlated with the SIA. Also, ROC analysis showed that these biochemical markers did not have a predictive value in estimating the size of experimental myocardial infarction.…”

Section: Presence Of An Infarct Area Equal To or Greater Than 20%mentioning

confidence: 57%

The Importance of ECG, Cardiac Troponin T and High Sensitive C Reactive Protein in Predicting the Extent of Experimental Myocardial Infarction in Rats

Aşgün¹,

Bağla²,

Ercan³

2017

Turkiye Klinikleri J Lab Anim

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A AB BS S T TR RA AC CT T O Ob bj je ec ct ti iv ve e: :To analyze the predictive value of ECG variables, cardiac troponin T (cTnT) and high-sensitive C reactive protein (hsCRP) levels in estimating the degree of experimental myocardial infarction in the living rats before euthanasia. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : Permanent ligation of the left anterior descending coronary artery was performed to develop acute myocardial infarction in 4-month-old male Wistar rats (n=18). Saline (n=5), low-dose erythropoietin (5 000 U.kg−1, n=6) and high-dose erythropoietin (10 000 U.kg−1, n=7) were administered intraperitoneally after the ligation to obtain varying degree of infarction. ECG records were taken before (phase 1), at the end of (phase 2), and at 6 hours after the ligation (phase 3). cTnT and hsCRP levels were measured in phase 3. The size of infarct area was calculated with planimetry on a single midventricular slice stained with triphenyltetrazolium chloride. R Re es su ul lt ts s: : The height of ST segment in phase 2, the Q/R and ST/R ratios measured in phase 3, and the Q/R ratio difference between phases 2 and 3 were found to be associated with the large infarct area. The cutoff values estimated for these variables were capable of predicting the presence of an infarct area ≥40%. cTnT and hsCRP levels were unsuccessful in estimating the size of infarction. C Co on nc cl lu us si io on n: : The variables of a 3-lead ECG may have a predictive value in estimating the presence of large infarction before euthanasia. ST segment elevation may be significantly different as early as the first-half hour of coronary ligation. The levels of cTnT and hsCRP are not associated with the size of infarction, and do not have a predictive value.K Ke ey y W Wo or rd ds s: : Myocardial infarction; erythropoietin; troponin t; c-reactive protein; electrocardiography Ö ÖZ ZE ET T A Am ma aç ç: : EKG değişkenleri, kardiyak troponin T (cTnT) ve yüksek duyarlıklı C reaktif protein (hsCRP) seviyelerinin, ratlarda oluşturulan deneysel miyokard infarktüsü derecesini ötenazi önce-sinde canlı hayvanda belirlenmesi için kullanılabilirliğinin araştırılmasıdır. G Ge er re eç ç v ve eY Yö ön nt te em ml le er r: : Dört aylık erkek Wistar ratlarda (n=18) akut miyokard infarktüsü oluşturmak için sol ön inen koroner artere kalıcı ligasyon uygulandı. Değişen büyüklüklerde infarktüs alanı elde etmek için ligasyon sonrası salin (n=5), düşük doz eritropoietin (5000 U.kg−1, n=6) ve yüksek doz eritropoietin (10000 U.kg−1, n=7) periton içine uygulandı. Ligasyon öncesinde (faz 1), ligasyon işlemi sonunda (faz 2) ve ligasyondan 6 saat sonra (faz 3) 3 elektrotlu EKG kayıtları alındı. cTnT ve hsCRP seviyeleri faz 3'de ölçüldü. İnfarktüs alanı, ventrikül ortasından alınan ve trifeniltetrazolyum klorür ile boyanan tek kesitte planimetri yöntemiyle hesaplandı. B Bu ul lg gu ul la ar r: : Faz 2'de ST segment yüksekliği, faz 3'de Q/R ve ST/R oranları ile faz 2 ve faz 3 arasında Q/R oranları farkı, büyük infarktüs alanı varlığı ile ilişkil...

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The role of C-reactive protein in ischemia/reperfusion injury and preconditioning in a rat model of myocardial infarction

Cited by 20 publications

References 29 publications

Remote Ischemic Postconditioning During Percutaneous Coronary Interventions

Remote Ischemic Postconditioning During Percutaneous Coronary Interventions

Prevention of Postoperative Atrial Fibrillation: Novel and Safe Strategy Based on the Modulation of the Antioxidant System

The Importance of ECG, Cardiac Troponin T and High Sensitive C Reactive Protein in Predicting the Extent of Experimental Myocardial Infarction in Rats

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