“…In addition, there is a growing interest in the role of the chromosome-associated bromodomain protein, BRD4. This protein is implicated in numerous cellular functions, including maintenance of stem cells (Liu et al, 2014;Rodriguez et al, 2014;Wu et al, 2015), regulation of the cell cycle (Josling et al, 2012;Mochizuki et al, 2008), tethering of persistent DNA viruses (Lin et al, 2008;You et al, 2004You et al, , 2006, and regulation of viral and host-cell gene transcription (McBride & Jang, 2013). Additionally, other investigators have identified BRD4 as a mediator of polyomaviral gene transcription and replication (Wollebo et al, 2016).…”