The Role of Breast‐Feeding in the Prevention of<i>Helicobacter pylori</i>Infection: A Systematic Review

Chak, Eric; Rutherford, George W.; Steinmaus, Craig

doi:10.1086/596499

Cited by 42 publications

(34 citation statements)

References 40 publications

(41 reference statements)

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“…A retrospective serological study by Blecker et al in a developed country showed that a small portion of the population acquired H. pylori infection (< 1%) during the 1st year of life (22). Acquisition of H. pylori infection usually occurs during the first 5 years of life (23).…”

Section: Discussionmentioning

confidence: 99%

Comparison of the Prevalence of Helicobacter pylori Infection Between the Exclusively Breastfed and Formula- or Mixed-Fed Infants in the First Six Months of Life

et al. 2017

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Background: Helicobacter pylori is a common gastrointestinal pathogen in human. The mechanism of its acquisition and transmission is unclear, although the most likely mode of transmission is fecal-oral or oral-oral. Most of infections occur in childhood. The current cohort assessed the prevalence of infection in infants with different feeding strategies (exclusive breastfeeding, formula, or mixed feeding). Methods: The current study was carried out in Vali-Asr hospital of Imam Khomeini hospital complex, Tehran, Iran, from 2012 to 2015.The study population included infants born in this hospital and registered in breastfeeding research center during the first 6 months of life. They were compared in 2 groups; exclusively breastfed, and formula or mixed fed. Mothers' H. pylori infection was checked serologically using the enzyme-linked immunosorbent assay (ELISA) technique and those of infants by monoclonal antibody test using ELISA technique on stool samples at 1st and 6th month of life. Results: A total of 102 infants in 2 groups (54 exclusively breastfed and 48 formula or mixed fed) completed the study. Mothers' serological assessments were positive in 68% of exclusively breast-fed subjects and 60% of formula or mixed fed subjects. All 1-monthold infants were negative for the infection and in the 6-month-old infants 10 cases (18.5%) were positive, 1 case was at borderline in the exclusively breastfed, and 13 cases (27%) were positive in formula-or mixed-fed subjects. This difference was not statistically significant (P = 0.302). The Mantel-Hanzel test was used to find a relationship in H. pylori positivity in mothers and infants during the first 6-month of life in each of the 2 groups. It was found that out of 37 serologically positive mothers in the breastfed group, 8 infants (22%) were H. pylori positive and in the formula and mixed-fed group, of 29 serologically positive mothers 10 infants (34%) were also H. pylori positive, but the difference between the groups was not statistically significant (P = 0.727). It meant that the prevalence of infantile H. pylori infection was similar in the 2 groups. Conclusions: The current study findings showed that exclusive breastfeeding had no role in protection or facilitation of H. pylori infection.

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Section: Discussionmentioning

confidence: 99%

Comparison of the Prevalence of Helicobacter pylori Infection Between the Exclusively Breastfed and Formula- or Mixed-Fed Infants in the First Six Months of Life

et al. 2017

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“…Some studies have demonstrated that breastfeeding is protective against the acquisition of H. pylori infection [31][32][33], while other studies have reported no protective effect of breastfeeding [3,5,34]. Prevalence of H. pylori infection in children breastfed longer than 12 months was lower than those breastfed for a shorter duration [OR (95% CI): 0.58 (0.35-0.94)] (Table 2).…”

Section: Discussionmentioning

confidence: 99%

Prevalence and Risk Factors of Helicobacter pylori Infection in Muong Children in Vietnam

Nguyen¹

2017

Ann Clin Lab Res

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Aim: H. pylori infection is predominantly acquired in early childhood. The aim of the present study was to determine the prevalence of H. pylori infection and to identify factors associated with the infection in Muong children living in Vietnam. Materials and methods:In a cross-sectional study 918 asymptomatic individuals of all generations living together in the same home were selected from 219 households, based on cluster sampling of residential location in Hoabinh Province, Vietnam. H. pylori infection status was determined by serology test on samples obtained at each visit. A questionnaire was filled out at the start of the study. H. pylori serology data were analyzed using χ 2 test and logistic regression models. Results Conclusion:The first community-based study in Muong population showed familial clustering in multi-generation population and supported the hypothesis of person-toperson transmission in H. pylori infection

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“…However, vaccine studies using mice lacking IgA or even all mature B cells have shown that vaccineinduced protection against Helicobacter infection in such mice is comparable to that in vaccinated wild-type mice (Ermak et al, 1998;Blanchard et al, 1999). As mentioned previously, H. pylori-specific SIgA antibodies in breast milk have been shown to be associated with protection against colonization in breast-fed children (Bhuiyan et al, 2010;Chak et al, 2009), which may suggest that partly different protective mechanisms might exist in mice and humans. It is noteworthy, however, that protection in the vaccinated mice lacking mature B cells is accompanied by more severe gastritis compared to similarly vaccinated wild-type mice, indicating that B cells, as suggested previously, might have an anti-inflammatory regulatory role in the stomach during H. pylori infection (Akhiani et al, 2004) (Figure 2).…”

Section: Lessons Learnt From Animal Modelsmentioning

confidence: 89%

“…A birth cohort study in Bangladesh showed that infants fed on breast milk containing high titers of H. pylori membrane protein-specific IgA antibodies had a significant delay in acquisition of H. pylori infection compared to infants fed on low-titer breast milk (Bhuiyan et al, 2010). A systematic analysis of studies on the role of breast-feeding in H. pylori infection has shown that breast-feeding can indeed protect against acquisition of new H. pylori infection, particularly in children in low-and middle-income countries (Chak et al, 2009). Further support for a protective role of SIgA antibodies came from a study showing that, whereas H. pylori infection in WT mice was spontaneously eradicated from the duodenum after three months, knockout mice lacking polymeric Ig receptor were abundantly colonized with H. pylori in the duodenum (Gorrell et al, 2013).…”

Section: Adaptive Immune Responsesmentioning

confidence: 99%

Helicobacter pylori Infection of the Gastric Mucosa

2015

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The Role of Breast‐Feeding in the Prevention ofHelicobacter pyloriInfection: A Systematic Review

Abstract: Breast-feeding is protective against H. pylori infection, especially in middle- and low-income nations.

Cited by 42 publications

References 40 publications

Comparison of the Prevalence of Helicobacter pylori Infection Between the Exclusively Breastfed and Formula- or Mixed-Fed Infants in the First Six Months of Life

Comparison of the Prevalence of Helicobacter pylori Infection Between the Exclusively Breastfed and Formula- or Mixed-Fed Infants in the First Six Months of Life

Prevalence and Risk Factors of Helicobacter pylori Infection in Muong Children in Vietnam

Helicobacter pylori Infection of the Gastric Mucosa

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