2020
DOI: 10.1159/000511552
|View full text |Cite
|
Sign up to set email alerts
|

The Role of Brain Microvascular Endothelial Cell and Blood-Brain Barrier Dysfunction in Schizophrenia

Abstract: <b><i>Background:</i></b> Despite decades of research, little clarity exists regarding pathogenic mechanisms related to schizophrenia. Investigations on the disease biology of schizophrenia have primarily focused on neuronal alterations. However, there is substantial evidence pointing to a significant role for the brain’s microvasculature in mediating neuroinflammation in schizophrenia. <b><i>Summary:</i></b> Brain microvascular endothelial cells (BMEC) are a cen… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

0
28
0

Year Published

2022
2022
2024
2024

Publication Types

Select...
8

Relationship

1
7

Authors

Journals

citations
Cited by 43 publications
(33 citation statements)
references
References 157 publications
(269 reference statements)
0
28
0
Order By: Relevance
“…The BBB is composed of a layer of brain microvascular endothelial cells (BMEC), which interact with neurons, glial cells, and the extracellular matrix to form the neurovascular unit. BMECs play a role in BBB permeability, brain parenchymal nourishment, and immune privilege in the brain [ 36 ].…”
Section: Resultsmentioning
confidence: 99%
See 2 more Smart Citations
“…The BBB is composed of a layer of brain microvascular endothelial cells (BMEC), which interact with neurons, glial cells, and the extracellular matrix to form the neurovascular unit. BMECs play a role in BBB permeability, brain parenchymal nourishment, and immune privilege in the brain [ 36 ].…”
Section: Resultsmentioning
confidence: 99%
“…Type 2 schizophrenics have increased expression in ICAM1 , IFITM1 , IFITM2 , CDH5 , CLDN5 , COL4A1 , and COL4A2 and decreased expression in ABCG2 ( Figure 8 C,D). ICAM1 and CDH5 contribute to the regulation of BBB permeability and are increased during inflammation in response to leukocyte migration [ 26 , 36 , 64 ]. Both have been observed to be increased in “high inflammation” schizophrenics [ 11 , 26 ].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…This observation coincides with our hypothesis that there may be an inflammation/vascular mediated effect on the choroid plexus, as well as other brain structures, resulting in what we call pseudothickening. 15 , 30 However, further investigations are needed to determine if there are sex-specific changes in the choroid plexus of psychosis patients and to dissect whether greater choroid plexus volume is due to microvascular or stromal changes.…”
Section: Discussionmentioning
confidence: 99%
“…Brain microvascular endothelial cells (BMECs) are a key element of the microvasculature that forms the BBB and shields the brain from toxins and reactive immune cells. However, it is not known whether BMECs themselves are functionally compromised and lead to BBB dysfunction in brain disorders[ 15 ]. An increased ratio of cerebrospinal fluid to serum albumin in patients with SC suggests increased permeability of the BBB[ 16 ].…”
Section: Introductionmentioning
confidence: 99%