The Role of Brain-Derived Neurotrophic Factor in the Pathophysiology of Psychiatric and Neurological Disorders

Angoa‐Pérez, Mariana; Anneken, John H.; Kuhn, Donald M.

doi:10.26502/jppd.2572-519x0025

Cited by 18 publications

(15 citation statements)

References 61 publications

(119 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, it is also important to point out the limitations of this study. Besides a single blood sample per volunteer, we only measured total BDNF levels instead of pro- and mature BDNF molecules, which are more specific biomarkers of apoptosis and neuroplasticity, respectively (Angoa-Perez et al, 2017). With respect to the sample, it was limited to a modest number of patients with treatment-resistant depression and comorbid personality and anxiety disorder.…”

Section: Discussionmentioning

confidence: 99%

Changes in inflammatory biomarkers are related to the antidepressant effects of Ayahuasca

et al. 2020

View full text Add to dashboard Cite

Background: Ayahuasca is a traditional Amazon brew and its potential antidepressant properties have recently been explored in scientific settings. We conducted a double-blind placebo-controlled trial of ayahuasca with treatment-resistant depression patients ( n = 28) and healthy controls ( n = 45). Aims: We are evaluating the blood inflammatory biomarkers: C-reactive protein and interleukin 6, as a potential consequence of ayahuasca intake and their correlation with serum cortisol and brain-derived neurotrophic factor levels. Blood samples were collected at pre-treatment and 48 hours after substance ingestion to assess the concentration of inflammatory biomarkers, together with administration of the Montgomery-Åsberg Depression Rating Scale. Results: At pre-treatment, patients showed higher C-reactive protein levels than healthy controls and a significant negative correlation between C-reactive protein and serum cortisol levels was revealed ( rho = –0.40, n = 14). C-reactive protein in those patients was not correlated with Montgomery-Åsberg Depression Rating Scale scores. We observed a significant reduction of C-reactive protein levels across time in both patients and controls treated with ayahuasca, but not with placebo. Patients treated with ayahuasca showed a significant correlation ( rho = + 0.57) between larger reductions of C-reactive protein and lower depressive symptoms at 48 hours after substance ingestion (Montgomery-Åsberg Depression Rating Scale). No significant result with respect to interleukin 6 and brain-derived neurotrophic factor was found. Furthermore, these biomarkers did not predict the antidepressant response or remission rates observed. Conclusions: These findings enhance the understanding of the biological mechanisms behind the observed antidepressant effects of ayahuasca and encourage further clinical trials in adults with depression.

show abstract

Section: Discussionmentioning

confidence: 99%

Changes in inflammatory biomarkers are related to the antidepressant effects of Ayahuasca

et al. 2020

View full text Add to dashboard Cite

show abstract

“…A number of reports show lower BDNF levels in brains with neurological diseases [ 2 – 4 , 10 , 11 ]. Non-invasive near-infrared in vivo BLI using Bdnf-Luc mice and TokeOni will allow changes in Bdnf expression in the brain under physiological and pathophysiological conditions to be examined.…”

Section: Discussionmentioning

confidence: 99%

“…Brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family, is fundamentally involved in a variety of functions in the developing and mature brain [ 1 ]. Consistent with the crucial roles of BDNF in the central nervous system (CNS), alterations in BDNF levels have been found in the brains of patients with neurodegenerative or neuropsychiatric diseases [ 2 – 4 ]. Abnormal expression levels of BDNF have been reported in the postmortem brains of Alzheimer’s disease [ 5 ], Parkinson’s disease [ 6 ], Huntington’s disease [ 7 ], depression [ 8 ], and schizophrenia [ 9 ].…”

Section: Introductionmentioning

confidence: 89%

Visualization of activity-regulated BDNF expression in the living mouse brain using non-invasive near-infrared bioluminescence imaging

et al. 2020

View full text Add to dashboard Cite

Altered levels of brain-derived neurotrophic factor (BDNF) have been reported in neurologically diseased human brains. Therefore, it is important to understand how the expression of BDNF is controlled under pathophysiological as well as physiological conditions. Here, we report a method to visualize changes in BDNF expression in the living mouse brain using bioluminescence imaging (BLI). We previously generated a novel transgenic mouse strain, Bdnf-Luciferase (Luc), to monitor changes in Bdnf expression; however, it was difficult to detect brain-derived signals in the strain using BLI with d-luciferin, probably because of incomplete substrate distribution and light penetration. We demonstrate that TokeOni, which uniformly distributes throughout the whole mouse body after systematic injection and produces a near-infrared bioluminescence light, was suitable for detecting signals from the brain of the Bdnf-Luc mouse. We clearly detected brain-derived bioluminescence signals that crossed the skin and skull after intraperitoneal injection of TokeOni. However, repeated BLI using TokeOni should be limited, because repeated injection of TokeOni on the same day reduced the bioluminescence signal, presumably by product inhibition. We successfully visualized kainic acid-induced Bdnf expression in the hippocampus and sensory stimulation-induced Bdnf expression in the visual cortex. Taken together, non-invasive near-infrared BLI using Bdnf-Luc mice with TokeOni allowed us to evaluate alterations in BDNF levels in the living mouse brain. This will enable better understanding of the involvement of BDNF expression in the pathogenesis and pathophysiology of neurological diseases.

show abstract

“…Both human and animal studies have shown that maternal iron deficiency affects the fetal production of BDNF and hippocampal morphogenesis [ 10 , 11 ]. Moreover, in many neurological and psychiatric diseases, such as Parkinson’s disease, Huntington’s disease, schizophrenia, Alzheimer’s disease, and depression, the concentration of BDNF was found to be low [ 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Maternal Iron Deficiency Programs Offspring Cognition and Its Relationship with Gastrointestinal Microbiota and Metabolites

Hsieh

Chen

Hsu

et al. 2020

IJERPH

View full text Add to dashboard Cite

Iron is an essential micronutrient for the brain development of the fetus. Altered intestinal microbiota might affect behavior and cognition through the so-called microbiota-gut-brain axis. We used a Sprague-Dawley rat model of a maternal low-iron diet to explore the changes in cognition, dorsal hippocampal brain-derived neurotrophic factor (BDNF) and related pathways, gut microbiota, and related metabolites in adult male offspring. We established maternal iron-deficient rats by feeding them a low-iron diet (2.9 mg/kg), while the control rats were fed a standard diet (52.3 mg/kg). We used a Morris water maze test to assess spatial learning and long-term memory. Western blot (WB) assays and a quantitative reverse-transcription polymerase chain reaction (qRT-PCR) were used to detect the BDNF concentration and related signaling pathways. We collected fecal samples for microbiota profiling and measured the concentrations of plasma short-chain fatty acids. The adult male offspring of maternal rats fed low-iron diets before pregnancy, during pregnancy and throughout the lactation period had (1) spatial deficits, (2) a decreased BDNF mRNA expression and protein concentrations, accompanied by a decreased TrkB protein abundance, (3) a decreased plasma acetate concentration, and (4) an enrichment of the Bacteroidaceae genus Bacteroides and Lachnospiraceae genus Marvinbryantia. Maternal iron deficiency leads to an offspring spatial deficit and is associated with alternations in gastrointestinal microbiota and metabolites.

show abstract

The Role of Brain-Derived Neurotrophic Factor in the Pathophysiology of Psychiatric and Neurological Disorders

Cited by 18 publications

References 61 publications

Changes in inflammatory biomarkers are related to the antidepressant effects of Ayahuasca

Changes in inflammatory biomarkers are related to the antidepressant effects of Ayahuasca

Visualization of activity-regulated BDNF expression in the living mouse brain using non-invasive near-infrared bioluminescence imaging

Maternal Iron Deficiency Programs Offspring Cognition and Its Relationship with Gastrointestinal Microbiota and Metabolites

Contact Info

Product

Resources

About