The Role of Bone in Chronic Rhinosinusitis

Khalid, Ayesha N.; Hunt, Jennifer L.; Perloff, Joel R.; Kennedy, David W.

doi:10.1097/00005537-200211000-00008

Cited by 96 publications

(110 citation statements)

References 24 publications

(40 reference statements)

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“…12 Chronic osteomyelitis accounts for the bone loss seen in primary atrophic rhinitis; furthermore, it contributes to the persistence of the neighbouring mucosal disease. 13,14 . This study undertook microbiological analysis of crusts and secretions obtained from 14 patients with primary atrophic rhinitis .…”

Section: Discussionmentioning

confidence: 99%

Microbiological study of role of fungi in primary atrophic rhinitis

Effat

Madany

2008

J. Laryngol. Otol.

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Background: Fungal rhinosinusitis has gained much attention in recent years. To our knowledge, no previous studies have addressed the role of fungus in primary atrophic rhinitis.Study design: Prospective case study. Patients and methods: All cases of primary atrophic rhinitis presenting to the out-patient department at El-Sahel Teaching Hospital over a five-month period were included in the study. Crusts and purulent secretions removed from patients' nasal cavities underwent microbiological analysis at the Medical Microbiology and Immunology department of the Cairo University Faculty of Medicine. Special emphasis was placed on fungal isolation.Results: Fourteen consecutive cases of primary atrophic rhinitis were studied in the five-month period starting 26 November 2007. Patients comprised eight females and six males, with an age range of 12 to 65 years (mean 37 years). Microscopy of the crusts and purulent secretions showed pus cells in most of the samples. Klebsiella species were isolated from nine patients (65 per cent), and other bacterial species were isolated in most of the remainder. Fungal elements, most commonly aspergillus species, were isolated in 13 patients (93 per cent).Conclusion: It is proposed that the initial trigger for primary atrophic rhinitis is a virulent bacterial infection of the nasal lining, which leads to damage of the ciliated epithelium. This initiates the cascade of events leading to inflammation of the mucosa and submucosa, with secondary pyogenic osteomyelitis of the turbinate bone. The persistence of purulent secretion, within the setting of impaired mucociliary clearance, leads to saprophytic fungal colonisation which contributes greatly to the clinical picture.

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Section: Discussionmentioning

confidence: 99%

Microbiological study of role of fungi in primary atrophic rhinitis

Effat

Madany

2008

J. Laryngol. Otol.

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“…388 Animal and human studies examining histopathologic changes of paranasal sinus mucosa and bone support its role in CRS. [389][390][391][392][393][394][395][396][397][398] Early studies by Kennedy et al 391 described the histomorphometry and histology of the ethmoid bone to better understand the pathogenesis of disease. Ethmoid bones harvested from patients with and without CRS were labeled with tetracycline and found to have significant activity by histologic evaluation (new bone formation, fibrosis, and inflammatory cell presence).…”

Section: S55mentioning

confidence: 99%

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

Orlandi

Kingdom

Hwang

et al. 2016

Int Forum Allergy Rhinol

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554

888

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Background:The body of knowledge regarding rhinosinusitis (RS) continues to expand, with rapid growth in number of publications, yet substantial variability in the quality of those presentations. In an effort to both consolidate and critically appraise this information, rhinologic experts from around the world have produced the International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR:RS). Methods:Evidence-based reviews with recommendations (EBRRs) were developed for scores of topics, using previously reported methodology. Where existing evidence was insufficient for an EBRR, an evidence-based review (EBR) was produced. The sections were then synthesized and the entire manuscript was then reviewed by all authors for consensus. Results:The resulting ICAR:RS document addresses multiple topics in RS, including acute RS (ARS), chronic RS (CRS) with and without nasal polyps (CRSwNP and CRSsNP), recurrent acute RS (RARS), acute exacerbation of CRS (AE-CRS), and pediatric RS. Conclusion:As a critical review of the RS literature, ICAR:RS provides a thorough review of pathophysiology and evidence-based recommendations for medical and surgical treatment. It also demonstrates the significant gaps in our understanding of the pathophysiology and optimal management of RS. Too o en the foundation upon which these recommendations are based is comprised of lowerlevel evidence. It is our hope that this summary of the evidence in RS will point out where additional research efforts may be directed. C 2016 ARS-AAOA, LLC. Key Words:rhinosinusitis; chronic rhinosinusitis; acute rhinosinusitis; recurrent acute rhinosinusitis; evidence-based medicine; systematic review; endoscopic sinus surgery List of Abbreviations Used

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“…In another study, 14 rabbits were induced by Staphylococcus aureus, chronic osteomyelitis in the non-infected side was found in (43%) (Khalid et al, 2002).…”

Section: Osteitis and Neo-osteogenesis In Rcrsmentioning

confidence: 94%