The role of blood transfusion in the management of upper and lower intestinal tract bleeding

Hearnshaw, Sarah; Travis, Simon; Murphy, Mike

doi:10.1016/j.bpg.2007.10.012

Cited by 14 publications

(9 citation statements)

References 60 publications

(40 reference statements)

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“…Current international guidelines on the management of critically ill patients recommend a transfusion trigger of 7 g/dL of hemoglobin, and a target level of 7 to 9 g/dL in the absence of coronary artery disease, tissue hypoperfusion or active hemorrhage [25][26][27][28]. However, at initial presentation, the hemoglobin level may not reliably reflect actual blood loss.…”

Section: Blood Transfusionmentioning

confidence: 99%

“…Cryoprecipitate can be used in active bleeding to maintain fibrinogen levels above 10 g/dL. Prothrombin complex concentrates containing vitamin K dependent factors can be given to a patient with a known vitamin K deficiency, or one who is overly anticoagulated with warfarin, keeping in mind that they can result in disseminated intravascular coagulation and thromboembolism, and so are not recommended in patients with liver disease [28].…”

Section: Correction Of Coagulopathymentioning

confidence: 99%

“…Replacement of the whole intravascular volume of patient with PRBCs on one occasion causes a reduction in coagulation factors of 70% [28]. Coagulopathy in a severely bleeding patient is multifactorial; it is effected by hypothermia, activation of fibrinolysis, impaired hepatic synthesis, acidosis and dilutional coagulopathy.…”

Section: Massive Transfusionmentioning

confidence: 99%

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Resuscitation and monitoring in gastrointestinal bleeding

Kilic

Konan

Kaynaroğlu

2011

Eur J Trauma Emerg Surg

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Section: Blood Transfusionmentioning

confidence: 99%

Section: Correction Of Coagulopathymentioning

confidence: 99%

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Resuscitation and monitoring in gastrointestinal bleeding

Kilic

Konan

Kaynaroğlu

2011

Eur J Trauma Emerg Surg

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“…In most institutions, the most common reason for MT is trauma (9). MT is also frequently required as treatment for severe hemorrhage in patients with gastrointestinal (GI) bleeding (10)(11)(12) and those undergoing surgery.…”

Section: Introductionmentioning

confidence: 99%

Fixed rate of blood component improves the survival rate of patients in massive transfusion

Wang

Zhan

et al. 2012

Biomedical Reports

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Abstract. The aim of this study was to examine the manner in which varying proportions of serum and red blood cells (RBC) in massive blood transfusion affect the survival rates of patients with severe blood loss. Massive transfusion (MT) was determined as receiving ≥10 units of red blood cells in 24 h. The electronic medical records and blood transfusion information for the period January, 2002 to December, 2011 of patients with MT were examined. Moreover, we calculated the ratio of blood components and examined their correlation with survival. In total, 1,658 patients underwent MT during the period 2002-2011, with an overall of 28,030 units RBC, accounting for 2.8% of the total blood transfusion. In conclusion, fixing blood-component ratios has the potential to help improve survival rate in MT.

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“…The most common reasons for Massive Transfusion (MT) is trauma 1 patients with GI bleeding [2][3][4] and surgical patients undergoing elective or emergent complex surgical procedures (like abdominal aortic aneurysm repair, orthotopic liver transplantation, major orthopedics surgery). [5][6][7] Other causes include cardiac & vascular surgery, ectopic pregnancy, major obstetric hemorrhage and post-partum uterine bleeding.…”

Section: Introductionmentioning

confidence: 99%

Management of Massive Blood Transfusion-a case study

Lima

Begum

Gupta

et al. 2014

PULSE

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Management of a complicated obstetric patient with profuse bleeding following caesarean section (under GA) required massive blood transfusion was managed properly with multidisciplinary approach in ICU. The involvement of obstetrician, anesthesiologist, intensivist, general surgeon, hematologist & gastroenterologist as a team in a single setup is essential for the management of such patients and the best outcome. The patient received total 117 units of blood products among which 20 units whole blood, 17 units packed red blood cell, 40 units of fresh frozen plasma and 40 units of platelet concentrate. Despite this massive blood transfusion, the patient recovered fully with minimal complications as we follow the near standard blood transfusion protocol. DOI: http://dx.doi.org/10.3329/pulse.v5i1.20189 Pulse Vol.5 January 2011 p.39-43

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The role of blood transfusion in the management of upper and lower intestinal tract bleeding

Cited by 14 publications

References 60 publications

Resuscitation and monitoring in gastrointestinal bleeding

Resuscitation and monitoring in gastrointestinal bleeding

Fixed rate of blood component improves the survival rate of patients in massive transfusion

Management of Massive Blood Transfusion-a case study

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