The role of Bleomycin in management of hypertrophic scars and keloids – A clinical trial

Reddy, Ravi Shankar; Sreekar, Harinatha; Raghunath, Nithya

doi:10.7241/ourd.20154.108

Cited by 2 publications

(3 citation statements)

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“…bleomycin usage has a better or comparable result as with other treatment modalities such as Triamcinolone and silicon gel sheets, and has minimal complications and less recurrence rate, which shows its usefulness as the first-line treatment modality for management of keloids and hypertrophic scars [12].…”

Section: Tissue Expression Ofmentioning

confidence: 92%

“…Reddy et al [12], (study included twenty patients, treated with intralesional injection of bleomycin, 13 (65%) showed excellent response, 3 (15%) showed good response, 2 (10%) showed fair response and 2 (10%) showed poor response. There was complete resolution of symptoms in 11 patients (55%) and improvement in the other 9 (45%) and this was in accordance to the current study results .…”

Section: Tissue Expression Ofmentioning

confidence: 99%

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Tissue Expression of Neuregulin-1 in Hypertrophic Scars and Keloids before and after Intralesional Bleomycin Injection

Sorour

Husseini

Mustafa

et al. 2020

Benha Journal of Applied Sciences

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Hypertrophic scars and keloids are forms of abnormal wound healing. Both entities are the result of exuberant fibroblast response in the dermis. Nevertheless, their clinical and histopathological characteristics, as well as their pathogenesis, are differentThe aim of this study was to study the role of neuregulin-1 in the pathogenesis of hypertrophic scars and keloids and studying the change in tissue expression after intralesional bleomycin injection. This prospective case -control study was carried on20patients who were suffering from keloids or hypertrophic scarsand were treated by intra lesional bleomycin injection, in addition to 20 apparently healthy individuals as a control group. Assement of hypertrophic scars and keloids before and after treatment byVancouver scar scale laboratory investigations including punch biopsies from hypertrophic scars, keloids and normal tissues, qRT-PCRfor gene expression of Neuregulin1 RNA was done. HTS group before treatment showed significantly higher level of neuregulin 1 but significantly lower after treatment and neuregulin 1 sensitivity was 80%, specificity was 100%,and accuracy was 90%.Neuregulin 1 before treatment showed significant positive correlation with Neuregulin 1after treatment.Better response was significantly associated with Lower baseline neuregulin 1.Higher neuregulin 1 was considered as risk predictor of HTS or keloid susceptibility and severity. Bleomycin usage has a better result and minimal complications and less recurrence rate, which shows its usefulness as the first-line treatment modality for management of keloids and hypertrophic scars.

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Section: Tissue Expression Ofmentioning

confidence: 92%

Section: Tissue Expression Ofmentioning

confidence: 99%

Tissue Expression of Neuregulin-1 in Hypertrophic Scars and Keloids before and after Intralesional Bleomycin Injection

Sorour

Husseini

Mustafa

et al. 2020

Benha Journal of Applied Sciences

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“…It is a polypeptide antibiotic possessing potent antitumor, antibacterial, and antiviral activity also used to treat HTS and keloids (Reddy et al 2015). The effectiveness of bleomycin in HTS was demonstrated through a clinical trial involving 20 patients with HTS and keloids.…”

Section: Bleomycinmentioning

confidence: 99%

Hypertrophic scars and keloids: a review and current treatment modalities

et al. 2020

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Hypertrophic scars (HTS) are raised, red, rigid, inflexible cell-like, and cosmetic problems precipitated due to multiple underlying dermal injuries such as burn, surgery, and trauma during which aberrant wound healing with more pathological deposition of the extracellular matrix than degradation leads to their spawning. Till date, well established and specific treatments for HTS have not been reported; hence, the need of recent developments is thrusted with novel drug delivery vision. This review will try to encompass all the agogs to HTS, definition, pathophysiology, mechanism of hypertrophic scar formation, the role of growth factors in hypertrophic scarring, and their difference with keloids. Further, it will illuminate the available medicaments and recent advances in novel topical drug delivery systems such as ethosomes, transethosomes, liposomes, solid lipid nanoparticles, and microsponges for treatment of HTS.

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The role of Bleomycin in management of hypertrophic scars and keloids – A clinical trial

Cited by 2 publications

References 0 publications

Tissue Expression of Neuregulin-1 in Hypertrophic Scars and Keloids before and after Intralesional Bleomycin Injection

Tissue Expression of Neuregulin-1 in Hypertrophic Scars and Keloids before and after Intralesional Bleomycin Injection

Hypertrophic scars and keloids: a review and current treatment modalities

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