The role of bitter and sweet taste receptors in upper airway innate immunity: Recent advances and future directions

Maina, Ivy W.; Workman, Alan D.; Cohen, Noam A.

doi:10.1016/j.wjorl.2018.07.003

Cited by 33 publications

(36 citation statements)

References 73 publications

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“…In the present work, we identified glucoputranjivin 3 as a selective agonist of T2R16 receptor in vitro. The result is consistent with the emerging role of the T2Rs in defense mechanisms in the airways, which have recently been proposed [28,29].…”

Section: Discussionsupporting

confidence: 91%

Glucosinolates in Sisymbrium officinale (L.) Scop.: Comparative Analysis in Cultivated and Wild Plants and in Vitro Assays with T2Rs Bitter Taste Receptors

et al. 2019

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Sisymbrium officinale (L.) Scop., commonly known as "hedge mustard" or "the singer's plant" is a wild plant common in Eurasian regions. Its cultivation is mainly dedicated to herboristic applications and it has only recently been introduced into Italy. The active botanicals in S. officinale are glucosinolates, generally estimated by using UV or high-performance liquid chromatography (HPLC). Using both techniques, we measured the total glucosinolates from S. officinale in different parts of the plant as roots, leaves, seeds, and flowers. A comparison was made for cultivated and wild samples, and for samples obtained with different pre-treatment and fresh, frozen, and dried storage conditions. Cultivated and wild plants have a comparable amount of total glucosinolates, while drying procedures can reduce the final glucosinolates content. The content in glucoputranjivin, which is the chemical marker for glucosinolates in S. officinale, has been determined using HPLC and a pure reference standard. Glucoputranjivin and two isothiocyanates from S. officinale have been submitted to in vitro assays with the platform of bitter taste receptors of the T2Rs family. The results show that glucoputranjivin is a selective agonist of receptor T2R16.

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Section: Discussionsupporting

confidence: 91%

Glucosinolates in Sisymbrium officinale (L.) Scop.: Comparative Analysis in Cultivated and Wild Plants and in Vitro Assays with T2Rs Bitter Taste Receptors

et al. 2019

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“…A cross-talk between signaling from T2Rs and toll-like receptors (TLRs) has been proposed by several authors (Lee and Cohen, 2015;Caputi and Giron, 2018;Maina et al, 2018). TLRs are a major class of pattern recognition receptors (PRRs) expressed in airway and intestinal cells that are able to activate inflammation through the transcription factor NF-KB.…”

Section: Role Of Taste Receptors In the Pd Pathological Processmentioning

confidence: 99%

“Smelling and Tasting” Parkinson's Disease: Using Senses to Improve the Knowledge of the Disease

Oppo

Melis

et al. 2020

Front. Aging Neurosci.

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Among non-motor manifestations of Parkinson's Disease (PD), peripheral, sensory symptoms are particularly relevant. Smell dysfunction starts very early and frequently precedes the PD motor symptoms by years (being often a cue to the diagnosis). Moreover, olfactory system could be, together with gut, one of those peripheral sites where PD pathology first develops. Unlike smell loss, the relationship between PD and taste impairment is far less established. It can start early in the course of the disease but more frequently appears in advanced stages, in parallel with the advent of MCI, likely reflecting cortical involvement. Among PD patients has been demonstrated an increase in the frequency of the non-tasters for PROP (prototypical gustatory stimulus, 6-n-propylthiouracil), a genetically determined bitter taste which is mediated by TAS2RS38 receptor, and a significant increase of the recessive non-testing variant of this receptor. TAS2R38 receptors are expressed also in other tissues, such as in the epithelia of the gut and nasal cavities, where they can influence epithelial immunity ad its interaction with microbiota. Those pieces of evidence suggest that not only systematic assessment of taste and smell can be of a remarkable help for clinicians in the early diagnosis, but also that understanding the mechanisms of sensory involvement in PD could increase the knowledge of the pathophysiology of the disease.

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“…Uncovering the full spectrum of bitter and sweet taste receptors expressed in the sinonasal epithelium will permit potential combinations of T1R agonist and T2R antagonists, maximizing the therapeutic benefit, either as adjunct or alternative therapies for patients with CRS . Although further evaluation of yet uncharacterized bitter and sweet taste receptor isoforms is required, research on the role of bitter and sweet taste receptors, especially T2R38 and its ligands, has exponentially increased the last decade.…”

Section: Resultsmentioning

confidence: 99%

Future topical medications in chronic rhinosinusitis

Miyake

Bleier

2019

Int Forum Allergy Rhinol

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Background:Research has progressed rapidly in recent decades to be er understand the etiopathogenesis and management paradigms of chronic rhinosinusitis (CRS). Although oral antibiotics o en mitigate symptoms in acute CRS exacerbations, eradication of polymicrobial biofilms and multidrug-resistant bacteria remains a challenge. The goal of this review is to summarize and discuss the potential and pitfalls of topical medications in the treatment of CRS. Methods:A related literature review was performed using PubMed and Scopus, with only the English database included. Results:The main therapies were selected and separated in sections. Details regarding future topical treatments of CRS were summarized and discussed. Conclusion:The ease of access of the sinonasal mucosa positions CRS as a disease with high potential for local topical treatment. The ultimate adoption of topical agents will require continued expansion of our understanding of novel local targets in CRS as well as improved methods to deliver and retain the drug of interest at the site of activity. C 2019 ARS-AAOA, LLC.

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The role of bitter and sweet taste receptors in upper airway innate immunity: Recent advances and future directions

Cited by 33 publications

References 73 publications

Glucosinolates in Sisymbrium officinale (L.) Scop.: Comparative Analysis in Cultivated and Wild Plants and in Vitro Assays with T2Rs Bitter Taste Receptors

Glucosinolates in Sisymbrium officinale (L.) Scop.: Comparative Analysis in Cultivated and Wild Plants and in Vitro Assays with T2Rs Bitter Taste Receptors

“Smelling and Tasting” Parkinson's Disease: Using Senses to Improve the Knowledge of the Disease

Future topical medications in chronic rhinosinusitis

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