The Role of Biomarker Macrophage Migration Inhibitory Factor in Cardiac Remodeling Prediction in Patients With St-Segment Elevation Myocardial Infarction

Abstract

The aim: To estimate the role of macrophage migration inhibitory factor and soluble ST2 in predicting the left ventricle remodeling six months after ST-segment elevation myocardial infarction. Materials and methods: The study involved 134 ST-segment elevation myocardial infarction patients. Occurrence of post-percutaneous coronary (PCI) intervention epicardial blood flow of TIMI <3 or myocardial blush grade 0-1 along with ST resolution <70% within 2 hours after PCI was qualified as the no-reflow condition. Left ventricle remodeling was defined after 6-months as an increase in left ventricle end-diastolic volume and/or end-systolic volume by more than 10%. Results: A logistic regression formula was evaluated. Included biomarkers were macrophage migration inhibitory factor and sST2, left ventricle ejection fraction: Y=exp(-39.06+0.82EF+0.096ST2+0.0028MIF) / (1+exp(-39.06+0.82EF+0.096ST2+0.0028MIF)). The estimated range is from 0 to 1 point. Less than 0.5 determines an adverse outcome, and more than 0.5 is a good prognosis. This equation, with sensitivity of 77 % and specificity of 85%, could predict the development of adverse left ventricle remodeling six months after a coronary event (AUC=0.864, CI 0.673 to 0.966, p<0.05). Conclusions: A combination of biomarkers gives a significant predicting result in the formation of adverse left ventricular remodeling after ST-segment elevation myocardial infarction.

Associations of health-related quality of life with major adverse cardiovascular and cerebrovascular events for individuals with ischaemic heart disease: systematic review, meta-analysis and evidence mapping

“…All studies were conducted in high-income countries except five multicentre international studies that also included participants from upper-middle-income 13 14 23–25 and lower-middle-income countries 24 and one single-centre study from lower-middle-income country. 26 …”

“…Overall, 11 (21.6%) and 25 (49.0%) and 11 (21.6%) of the included articles were published after 2000, 2010 and 2020, respectively, with the latest included article published in 2023. 26 We found variations in the design, patient population, HRQoL assessment, follow-up duration and outcome definitions between the included studies ( figure 2 , table 1 , online supplemental table S2a , online supplemental table S2b ). The start of patient recruitment period ranged from June 1998 to August 2021.…”

“…All studies were conducted in high-income countries except five multicentre international studies that also included participants from uppermiddle-income 13 14 23-25 and lower-middle-income countries 24 and one single-centre study from lower-middleincome country. 26 Overall, 11 (21.6%) and 25 (49.0%) and 11 (21.6%) of the included articles were published after 2000, 2010 and 2020, respectively, with the latest included article published in 2023. 26 We found variations in the design, patient population, HRQoL assessment, follow-up duration and outcome definitions between the included studies (figure 2, table 1, online supplemental table S2a, online supplemental table S2b).…”