The Role of Biologics in the Treatment of Chronic Rhinosinusitis

Haloob, Nora; Karamali, Katerina; Claire, Hopkins

doi:10.1007/s40259-023-00602-9

Cited by 5 publications

(2 citation statements)

References 53 publications

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“…More research based on new therapeutic targets and carefully selected biological agents is necessary to confirm their safety and therapeutic effectiveness. For biological agents to become a new treatment for most patients, in addition to traditional drugs and surgery, cost reduction will be necessary [ 104 , 119 ].…”

Section: Biological Treatmentmentioning

confidence: 99%

Chronic Rhinosinusitis—Microbiological Etiology, Potential Genetic Markers, and Diagnosis

Michalik,

Krawczyk

2024

IJMS

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Chronic rhinosinusitis (CRS) is a significant public health problem. Bacterial colonization and impaired mucociliary clearance play a significant role in the inflammatory process. Several inflammatory pathways and host defense elements are altered in CRS, which may contribute to observed differences in the microbiome. To date, researching CRS has been difficult due to limited access to the studied tissue and a lack of available biomarkers. Ongoing scientific research is increasingly based on simple and objective analytical methods, including sensors, detection with PCR, and sequencing. Future research on microbiota and human factors should also include genomics, transcriptomics, and metabolomics approaches. This report analyzes the changes that occur in the paranasal sinuses of people with acute and chronic rhinosinusitis, the composition of the microbiota, the human genetic markers that may shed light on the predisposition to CRS, and the advantages and disadvantages of classical and molecular diagnostic methods, as well as addressing the difficulties of sinusitis treatment.

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Section: Biological Treatmentmentioning

confidence: 99%

Chronic Rhinosinusitis—Microbiological Etiology, Potential Genetic Markers, and Diagnosis

Michalik,

Krawczyk

2024

IJMS

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“…Additionally, inspired by significant advances in asthma treatment, biologics have become the focus of CRS treatment in recent years ( Table 1 ). In fact, some biologics have shown remarkable improvements in the severity of refractory CRSwNP and AECRS on both the subjective and objective indicators ( 18 , 19 ). These biologics, primarily focusing on cytokines, cytokine receptors or antibody bindings, appear to provide a new perspective that the different cytokines, immune cells and remodeling factors related to CRS could potentially be key in breaking the prevailing belief that remodeling and inflammation do not interact during disease progression.…”

Section: Introductionmentioning

confidence: 99%

The interplay of inflammation and remodeling in the pathogenesis of chronic rhinosinusitis: current understanding and future directions

Gong,

Han,

Fan

et al. 2023

Front. Immunol.

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Chronic rhinosinusitis (CRS), a common clinical condition characterized by persistent mucosal inflammation and tissue remodeling, has a complex pathogenesis that is intricately linked to innate and adaptive immunity. A number of studies have demonstrated that a variety of immune cells and cytokines that play a vital role in mediating inflammation in CRS are also involved in remodeling of the nasal mucosa and the cells as well as different cytokines involved in remodeling in CRS are also able to exert some influence on inflammation, even though the exact relationship between inflammation and remodeling in CRS has not yet been fully elucidated. In this review, the potential role of immune cells and cytokines in regulating inflammation and remodeling of CRS mucosa has been described, starting with the immune cells and cytokines that act together in inflammation and remodeling. The goal is to aid researchers in understanding intimate connection between inflammation and remodeling of CRS and to offer novel ideas for future research.

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Efficacy of different biologics for treating chronic rhinosinusitis with nasal polyps: a network meta-analysis

Wang,

Xu,

et al. 2024

Eur Arch Otorhinolaryngol

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The Role of Biologics in the Treatment of Chronic Rhinosinusitis

Cited by 5 publications

References 53 publications

Chronic Rhinosinusitis—Microbiological Etiology, Potential Genetic Markers, and Diagnosis

Chronic Rhinosinusitis—Microbiological Etiology, Potential Genetic Markers, and Diagnosis

The interplay of inflammation and remodeling in the pathogenesis of chronic rhinosinusitis: current understanding and future directions

Efficacy of different biologics for treating chronic rhinosinusitis with nasal polyps: a network meta-analysis

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