The Role of Bioactive Peptides in Diabetes and Obesity

Chelliah, Ramachandran; Shuai, Wei; Daliri, ‪Eric Banan-Mwine; Elahi, Fazle; Yeon, Su‐Jung; Tyagi, Akanksha; Liu, Shucheng; Madar, Inamul Hasan; Sultan, Ghazala; Oh, Deog‐Hwan

doi:10.3390/foods10092220

Cited by 38 publications

(17 citation statements)

References 99 publications

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“…Although whey protein and WP have similar biological benefits, a recent study demonstrated that WP more efficiently reduced aging-related oxidative stress compared to whey protein [ 26 ]. It might be because bioactive peptides have stronger cellular affinity and specificity with a higher absorption rate than proteins [ 28 ], which is expected to be more effective for metabolic disorders such as obesity [ 29 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Whey Peptide Supplementation on Sarcopenic Obesity in High-Fat Diet-Fed Mice

Lim

2022

Nutrients

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The incidence of sarcopenic obesity gradually increased in parallel with the aged population. This research examined the effects of whey peptide (WP) supplementation with/without resistant exercise (RE) on sarcopenic obesity. Male 8-month-old C57BL/6J mice were fed a control diet (10 kcal% fat) or a high-fat diet (60 kcal% fat) for 8 weeks. High-fat diet-fed mice were randomly divided into four groups: obesity control group (OB), RE (RE only), WP (WP only), and WPE (RE and WP). WP supplementation (1500 mg/day/kg B.W.) gavage and RE (ladder climbing, five times weekly, 8–10 repetitions, 10–20% B.W. load) were conducted for an additional 8 weeks. Protein and mRNA levels of markers related to energy, protein, and lipid metabolism were analyzed in skeletal muscle and adipose tissue by one-way analysis of variance (ANOVA). WP supplementation regardless of RE significantly suppressed the increasing fat mass (p = 0.016) and decreasing lean mass (p = 0.014) and alleviated abnormal morphological changes in skeletal muscle and adipose tissue (p < 0.001). In adipose tissue, WP supplementation regardless of RE ameliorated dysregulated energy metabolism and contributed to the reduction in adipocyte differentiation (PPAR-γ (p = 0.017), C/EBPα (p = 0.034)). In skeletal muscle, WP supplementation regardless of RE alleviated energy metabolism dysregulation and resulted in down-regulated protein degradation (Atrogin-1 (p = 0.003), MuRF1 (p = 0.006)) and apoptosis (Bax) (p = 0.004). Taken together, the current study elucidated that WP supplementation regardless of RE has potential anti-obesity and anti-sarcopenic effects in sarcopenic obesity.

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Section: Introductionmentioning

confidence: 99%

Effects of Whey Peptide Supplementation on Sarcopenic Obesity in High-Fat Diet-Fed Mice

Lim

2022

Nutrients

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“…The body weight and food intake of all patients with type 2 diabetes were measured every week, and the effects of the peptide drug tripeptide nano preparation and sodium-glucose co-transporter 2 inhibitor on body weight and food were observed (23). Then, patients in the standard room breathe at 450nm wavelength to measure the luminosity (OD value) of apolipoprotein, the calculated multimetabolism is given by the leopard nano preparation team, sodium glucometer transporter-2 team and the drug inhibitor polydrug.…”

Section: Methods For Detecting Relevant Indexes Of Type 2 Diabetes Pa...mentioning

confidence: 99%

Effect of Peptide Drug Liraglutide Nano-Formulation Combined with Sodium-Glucose Cotransporter-2 Inhibitor on Blood Lipids in Patients with Type 2 Diabetes

She¹,

Liu²

2022

Cell Mol Biol (Noisy-le-grand)

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With the aging of our population and the increase in the number of obese people, diabetes has become a common disease. At present, drug treatment is mainly used for diabetes. Dyslipidemia is the main cause of diabetes. The regulation of blood lipids in diabetic patients through drugs is the key to treating diabetes. The purpose of this article is to further explore the specific effect and mechanism of peptide drug liraglutide nano-formulation combined with sodium-glucose co-transporter-2(SGCT-2) inhibitor on blood lipids in patients with type 2 diabetes. This article uses 30 people included in our hospital in 2019 2 patients with type 2 diabetes are divided into the group of peptide drug liraglutide nano preparations, the group of SGCT-2 inhibitors and the peptide drug liraglutide nano preparations combined with SGCT-2. In the inhibitor combination medication group, patients were given drug intervention according to the group name with the consent of the patients. After three days, the serum cholesterol, triglyceride, lipoprotein and lipid metabolism levels of all patients were tested. The results showed that under the intervention of peptide drug liraglutide nanoparticles combined with SGCT-2 inhibitor, the cholesterol level of patients with type 2 diabetes decreased from (368.2 ± 8.3) mmol / L to (1978.4 ± 4.7) mmol/L, triglyceride level decreased from (653.7 ± 12.5) mg/dL to (426.8 ± 9.6) mg/dl, and lipid metabolism level increased by 25.6%. Therefore, it can be seen that the peptide drug liraglutide nano preparation combined with SGCT-2 inhibitor has a certain therapeutic effect on type 2 diabetes.

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“…Microbial action, mainly by the gastrointestinal microbiota, on food proteins can generate bioactive peptides, including food-derived compounds with anti-inflammatory activity, and is exerted through the inhibition of signaling components belonging to either the NF-κB or the MAPK pathways [ 21 , 22 ], as well as proteases produced by psychrotrophic bacteria, which are microorganisms that can grow at temperatures used for refrigeration and storage of foodstuffs [ 23 ]. It is currently clear that diseases, such as type 2 diabetes, can be successfully treated simply by consuming diets that generate these bioactive anti-inflammatory peptides [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

Proteomics Characterization of Food-Derived Bioactive Peptides with Anti-Allergic and Anti-Inflammatory Properties

et al. 2022

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Bioactive peptides are found in foods and dietary supplements and are responsible for health benefits with applications in human and animal medicine. The health benefits include antihypertensive, antimicrobial, antithrombotic, immunomodulatory, opioid, antioxidant, anti-allergic and anti-inflammatory functions. Bioactive peptides can be obtained by microbial action, mainly by the gastrointestinal microbiota from proteins present in food, originating from either vegetable or animal matter or by the action of different gastrointestinal proteases. Proteomics can play an important role in the identification of bioactive peptides. High-resolution mass spectrometry is the principal technique used to detect and identify different types of analytes present in complex mixtures, even when available at low concentrations. Moreover, proteomics may provide the characterization of epitopes to develop new food allergy vaccines and the use of immunomodulating peptides to induce oral tolerance toward offending food allergens or even to prevent allergic sensitization. In addition, food-derived bioactive peptides have been investigated for their anti-inflammatory properties to provide safer alternatives to nonsteroidal anti-inflammatory drugs (NSAIDs). All these bioactive peptides can be a potential source of novel drugs and ingredients in food and pharmaceuticals. The following review is focused on food-derived bioactive peptides with antiallergic and anti-inflammatory properties and summarizes the new insights into the use of proteomics for their identification and quantification.

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The Role of Bioactive Peptides in Diabetes and Obesity

Cited by 38 publications

References 99 publications

Effects of Whey Peptide Supplementation on Sarcopenic Obesity in High-Fat Diet-Fed Mice

Effects of Whey Peptide Supplementation on Sarcopenic Obesity in High-Fat Diet-Fed Mice

Effect of Peptide Drug Liraglutide Nano-Formulation Combined with Sodium-Glucose Cotransporter-2 Inhibitor on Blood Lipids in Patients with Type 2 Diabetes

Proteomics Characterization of Food-Derived Bioactive Peptides with Anti-Allergic and Anti-Inflammatory Properties

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