The Role of Bioactive Compounds of Nigella sativa in Rheumatoid Arthritis Therapy—Current Reports

Zielińska, Magdalena; Dereń, Katarzyna; Polak-Szczybyło, Ewelina; Stępień, Agnieszka Ewa

doi:10.3390/nu13103369

Cited by 13 publications

(18 citation statements)

References 87 publications

(83 reference statements)

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“…Concomitant NS treatment with AA significantly decreased liver IL-1β levels, while this decrease in TNF-α level, although not significant, tended to decrease (Figure 2). The reason for this is thought to suppress the inflammatory process by neutralizing the oxidative stress that causes liver damage, thanks to the antioxidative and antiinflammatory effects of NS (48). Our findings are also consistent with another study stating that thymiconicone, the main component of NS, decreased the activities of inflammatory markers such as TNF-α and IL-1β in rats exposed to experimental AA toxicity (1).…”

Section: Discussionsupporting

confidence: 92%

“…NS, generally known as black seed or black cumin, has traditionally been used as a food preservative, additive, or applied as spice (6). According to the findings obtained from the studies carried out NS has antioxidative, anti-inflammatory, antifungal, anticonvulsant, immunomodulator, antinociceptive, antiallergic, antibacterial, antiviral, antidiabetic, antitumor, anti-hepato-nephrotoxic and neuroprotective effects (7,43,48).…”

Section: Introductionmentioning

confidence: 99%

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Hepatoprotective effects of Nigella Sativa oil against acrylamide-induced liver injury in rats

Hatipoğlu¹,

ÖZSAN

DÖNMEZ³

et al. 2023

Ankara Üniversitesi Veteriner Fakültesi Dergisi

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This study was designed to investigate the possible protective efficacy of Nigella sativa essential oil against acrylamide induced liver toxicity. Four groups of 32 male Wistar albino rats were formed. Control group was used as a control. acrylamide was administered to the rats in Group AA by gavage at a daily dose of 40 mg/kg. 10mg/kg dose of Nigella sativa essential oil was administered intraperitoneally to the rats in Group NS. In Group AA+NS, daily acrylamide and Nigella sativa essential oil applications were carried out simultaneously as mentioned above. The trial period lasted 15 days. While acrylamide increased malondialdehyde levels in liver tissue, it decreased glutathione and superoxide dismutase levels. In addition, liver pro-inflammatory cytokine levels increased due to acrylamide administration, while anti-inflammatory cytokine levels decreased due to acrylamide administration.: Concomitant administration of Nigella sativa essential oil with acrylamide significantly reduced oxidative stress and inflammation in liver tissues. In conclusion, our findings emphasized that Nigella sativa essential oil has a potential therapeutic role to prevent acrylamide-induced hepatotoxicity.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Hepatoprotective effects of Nigella Sativa oil against acrylamide-induced liver injury in rats

Hatipoğlu¹,

ÖZSAN

DÖNMEZ³

et al. 2023

Ankara Üniversitesi Veteriner Fakültesi Dergisi

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“…The research of Bordoni et al [5] showed anti-Inflammatory properties of Nigella sativa oil related to the thymoquinone content, but also on other antioxidant components of the oil. As related by Zieli ńska et al [6], black cumin plays a supporting role in the treatment of autoimmune diseases, including Molecules 2022, 27, 652 2 of 16 rheumatoid arthritis. The food industry is also paying attention to the use of the Salvia hispanica seeds, which are a natural source of omega-3 and omega-6, fiber, proteins, and natural antioxidants such as polyphenols [8].…”

Section: Introductionmentioning

confidence: 85%

“…Salvia hispanica (chia) and Nigella sativa (black cumin) seeds are known as natural sources of bioactive compounds [4][5][6][7]. The biological activity of Nigella sativa seed has been associated with tocopherols, vitamin A and C, β-carotene, thymoquinone, saponins, and alcaloids [4].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Salvia hispanica and Nigella sativa Seed on the Volatile Profile and Sensory Parameters Related to Volatile Compounds of Dry Fermented Sausage

2022

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The aim of the study was to evaluate the effects of Salvia hispanica and Nigella sativa seed addition on the volatile compounds and sensory characteristics (with particular emphasis on odor and flavor) of traditionally produced dry fermented sausages with reduced nitrites. Five different sausage formulations were prepared: control sample; samples with 1% and 2% addition of chia seed; samples with 1% and 2% addition of black cumin seed. The sausages were subjected to analysis including proximate chemical composition, volatile compound determination, and sensory analysis. The sausages with chia seed in the amounts of 1% and 2% as well as the sample with 1% addition of black cumin seed were characterized by positive sensory features, and their overall quality was rated above 7 c.u. on a 10-point scale, similar to the control sausage. Sausage samples with the addition of cumin seed were characterized by the highest herbal odor and flavor. The addition of Salvia hispanica and Nigella sativa seed significantly affected the amount of volatile compounds in fermented sausages. Sausages with black cumin presented the greatest amount of total volatile compounds, mainly contributed by terpenes.

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“…TQ also plays anti-inflammatory roles in a variety of diseases including sepsis, rheumatoid arthritis, obesity, and infectious diseases [ 76 , 77 , 78 ]. However, the underlying mechanisms remain unclear and require further study.…”

Section: Anti-inflammatory Effect Of Tq In Other Diseasesmentioning

confidence: 99%

The Role of Thymoquinone in Inflammatory Response in Chronic Diseases

Liu

Huang

Kim

et al. 2022

IJMS

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Anti-inflammatory therapies have been shown to be effective in the prevention of various cardiovascular diseases, tumors, and cancer complications. Thymoquinone (TQ), the main active constituent of Nigella sativa, has shown promising therapeutic properties in many in vivo and in vitro models. However, TQ has poor bioavailability and is hydrophobic, prohibiting clinical trials with TQ alone. Studies have explored the combination of TQ with biological nanomaterials to improve its bioavailability. The TQ nanoparticle formulation shows better bioavailability than free TQ, and these formulations are ready for clinical trials to determine their potential as therapeutic agents. In this paper, we review current knowledge about the interaction between TQ and the inflammatory response and summarize the research prospects in Korea and abroad. We discuss the different biological activities of TQ and various combination therapies of TQ and nanomaterials in clinical trials.

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The Role of Bioactive Compounds of Nigella sativa in Rheumatoid Arthritis Therapy—Current Reports

Cited by 13 publications

References 87 publications

Hepatoprotective effects of Nigella Sativa oil against acrylamide-induced liver injury in rats

Hepatoprotective effects of Nigella Sativa oil against acrylamide-induced liver injury in rats

The Effect of Salvia hispanica and Nigella sativa Seed on the Volatile Profile and Sensory Parameters Related to Volatile Compounds of Dry Fermented Sausage

The Role of Thymoquinone in Inflammatory Response in Chronic Diseases

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