The Role of Big Data and Advanced Analytics in Drug Discovery, Development, and Commercialization

Szlezák, N; Evers, Matthias R.; Wang, J; Pérez, Liliana

doi:10.1038/clpt.2014.29

Cited by 59 publications

(50 citation statements)

References 3 publications

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“…There has been an explosion of health-care data available in the past decade (Szlezak, 2014). This offers a great opportunity not only for researchers but other stakeholders to make big advances in health care.…”

Section: Advantages Challenges and Limitations Of E-technology Imentioning

confidence: 99%

“…Once researchers figure this out, the other challenge is data quality and consistency, given the current absence of standard methodologies, such as unique identifiers for patients, physicians, and diseases for use across all data types (Szlezak et al, 2014) and varying expectations and time to collect fully complete data within EHRs.…”

Section: Advantages Challenges and Limitations Of E-technology Imentioning

confidence: 99%

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Using e-technologies in clinical trials

Rosa

Campbell

Miele

et al. 2015

Contemporary Clinical Trials

135

111

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Clinical trials have been slow to incorporate e-technology (digital and electronic technology that utilizes mobile devices or the Internet) into the design and execution of studies. In the meantime, individuals and corporations are relying more on electronic platforms and most have incorporated such technology into their daily lives. This paper provides a general overview of the use of e-technologies in clinical trials research, specifically within the last decade, marked by rapid growth of mobile and Internet-based tools. Benefits of and challenges to the use of e-technologies in data collection, recruitment and retention, delivery of interventions, and dissemination are provided, as well as a description of the current status of regulatory oversight of e-technologies in clinical trials research. As an example of ways in which e-technologies can be used for intervention delivery, a summary of e-technologies for treatment of substance use disorders is presented. Using e-technologies to design and implement clinical trials has the potential to reach a wide audience, making trials more efficient while also reducing costs; however, researchers should be cautious when adopting these tools given the many challenges in using new technologies, as well as threats to participant privacy/confidentiality. Challenges of using e-technologies can be overcome with careful planning, useful partnerships, and forethought. The role of web- and smartphone-based applications is expanding, and the increasing use of those platforms by scientists and the public alike make them tools that cannot be ignored.

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Section: Advantages Challenges and Limitations Of E-technology Imentioning

confidence: 99%

Section: Advantages Challenges and Limitations Of E-technology Imentioning

confidence: 99%

Using e-technologies in clinical trials

Rosa

Campbell

Miele

et al. 2015

Contemporary Clinical Trials

135

111

View full text Add to dashboard Cite

show abstract

“…According to Szelak (2014), the last two decades have seen an explosion in big data throughout the healthcare value chain, as well as the advent of new platforms, tools, and methodologies in storing, structuring, and analysing big data. Important developments include the use of genomic data in drug discovery, the sharing of clinical-trial data, the use of electronic healthcare records (EHRs), and the increased availability of data from mobile health applications, patient registries, and social media (Szlezak, 2014).…”

Section: ____________________________________________________________mentioning

confidence: 99%

A Comparative Analysis of User Insights for E-Health Development Challenges in Turkey, Kingdom of Saudi Arabia, Egypt and United Arab Emirates

Uluc¹

2016

Pressacademia

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Implementation of e-health is expected to affect the outcomes of medical services positively, by contributing to the effectiveness and efficiency of overall healthcare ecosystem. This becomes more crucial in developing countries where access, finance, resources and competent professionals in healthcare are limited. This field study assesses healthcare professionals' insights, for the major challenges of ehealth development with a distinctive model and comparative analysis in four emerging countries; Turkey, Kingdom of Saudi Arabia, United Arab Emirates and Egypt. The research is conducted by user questionnaires and face to face interviews of healthcare professionals. Results indicate that information communication technology infrastructure, regulations, cultural and clinical adaptation of users, financing, supply chain management are some major challenges. Specially trust to e-business in healthcare, compliant use of big data in digital health and patient privacy play a key role for faster development of e-health.

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“…[1][2][3] The US Food and Drug Administration (FDA)'s Manufacturer and User Facility Device Experience (MAUDE) database) is one such resource. MAUDE contains over four million medical device adverse event and product problem reports dating back to 1991.…”

Section: Introductionmentioning

confidence: 99%