The role of bicarbonate pathophysiology and therapy in Asiatic cholera

Beisel, William R.; Watten, Raymond H.; Blackwell, R. Q.; Benyajati, C.; Phillips, R A

doi:10.1016/0002-9343(63)90164-5

Cited by 18 publications

(2 citation statements)

References 22 publications

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“…Severe diarrhoea is commonly associated with metabolic acidosis, attributed to the loss in the stools of alkaline intestinal contents or ofsecretions containing proportionately less chloride and more bicarbonate than the blood plasma (Beisel, Watten, Blackwell, Benyajati, and Phillips 1963). Exceptionally, a patient with either acute (Maizels andMcArthur, 1929, 1930) or chronic diarrhoea (Lubran and McAllen, 1951;Schwartz, and Relman 1953;de Graeff and Schuurs, 1960;Aber, Sampson, Whitehead, and Brooke, 1962) is found to have a metabolic alkalosis apparently caused by the development of potassium deficiency; but the few such cases that have been studied in detail (Schwartz and Relman, 1953;de Graeff and Schuurs, 1960) showed nothing distinctive about the chemical composition of the stools.…”

mentioning

confidence: 99%

Congenital chloridorrhoea or so-called congenital alkalosis with diarrhoea

Evanson¹,

Stanbury²

1965

Gut

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mentioning

confidence: 99%

Congenital chloridorrhoea or so-called congenital alkalosis with diarrhoea

Evanson¹,

Stanbury²

1965

Gut

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“…An accurate, dynamic understanding of the physiologic derangements of cholera emerged that substantiated and greatly extended observations made during the Cairo epidemic. On the basis of these studies, Phillips' group further refined their evidence-based approach to management with fluids [22][23][24][25].…”

Section: Recommissioning Of Namru-2 In Taipei and The Advent Of The Smentioning

confidence: 99%

A Legacy in 20th‐Century Medicine: Robert Allan Phillips and the Taming of Cholera

Savarino

2002

CLIN INFECT DIS

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The legacy of Captain Robert Allan Phillips (1906-1976) was to establish effective, evidence-based rehydration methods for the treatment of cholera. As a Navy Lieutenant at the Rockefeller Institute for Medical Research (New York, New York) during World War II, Phillips developed a field method for the rapid assessment of fluid loss in wounded servicemen. After the war, he championed the establishment of United States Naval Medical Research Unit (NAMRU)-3 (Cairo; 1946) and NAMRU-2 (Taipei; 1955), serving at the helm of both units. Phillips embarked on cholera studies during the 1947 Egyptian cholera epidemic and brought them to maturity at NAMRU-2 (1958-1965), elucidating the pathophysiologic derangements induced by cholera and developing highly efficacious methods of intravenous rehydration. His conception of a simpler cholera treatment was realized in the late 1960s with the development of glucose-based oral rehydration therapy, a monumental breakthrough to which many other investigators made vital contributions. Today, these simple advances have been integrated into everyday medical practice across the globe, saving millions of lives annually.

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Pathophysiology and Clinical Aspects of Cholera

Rabbani¹,

GreenoughIII²

1992

Cholera

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The role of bicarbonate pathophysiology and therapy in Asiatic cholera

Cited by 18 publications

References 22 publications

Congenital chloridorrhoea or so-called congenital alkalosis with diarrhoea

Congenital chloridorrhoea or so-called congenital alkalosis with diarrhoea

A Legacy in 20th‐Century Medicine: Robert Allan Phillips and the Taming of Cholera

Pathophysiology and Clinical Aspects of Cholera

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