The role of bevacizumab on tumour angiogenesis and in the management of gynaecological cancers: A review

Chellappan, Dinesh Kumar; Leng, Kun Hooi; Jia, Lee Jia; Aziz, Nur Amirah Binti Abdul; Wong, Chun Hoong; Qian, Yap Cheng; Ling, Fam Yi; Wei, Gwee Sing; Ying, Tiong; Chellian, Jestin; Gupta, Gaurav; Dua, Kamal

doi:10.1016/j.biopha.2018.03.061

Cited by 41 publications

(35 citation statements)

References 197 publications

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“…The pesticide DML was accounted for in expanding MDA in renal tissue, serum creatinine, and urea, while cell antioxidative markers were diminished in rats. Long term administration of DLM in rabbits initiated significant oxidative DNA harm in the liver and kidney and fundamentally decreased plasma CAT, GSH, and TAC levels . The serum levels of TNF‐α, lactate dehydrogenase, alanine transaminase, and aspartate aminotransferase were fundamentally increased by subacute administration of DLM in rats.…”

Section: Discussionmentioning

confidence: 99%

Curcumin synergistically potentiates the protective effect of sitagliptin against chronic deltamethrin nephrotoxicity in rats: Impact on pro‐inflammatory cytokines and Nrf2/Ho‐1 pathway

Shi

Zhang

Wang

et al. 2019

J Biochem & Molecular Tox

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Deltamethrin (DLM) is a synthesized organophosphorus acaricide and bug spray, broadly utilized for veterinary and farming purposes. Although its exposure to humans and animals causes toxicity in the kidney and other primary organs, our objective was to assess the defensive effects of sitagliptin (Sita) and additionally curcumin (Cur) in the DLM‐intoxicated rats’ kidney. DLM‐intoxicated rats revealed a huge increase of various biochemical parameters in serum identified with kidney damage: uric acid, urea, and creatinine. DLM intoxication altogether increased renal lipid peroxidation, and critically restrained antioxidative biomarkers including superoxide dismutase, glutathione, and glutathione peroxidase. Likewise, it increased the tumor necrosis factor‐α, interleukin 6 (IL‐6) and IL‐1β level in serum. Additionally, DLM intoxication diminished the outflow of the nuclear factor (erythroid‐derived 2)‐like 2 (Nrf2)/heme oxygenase‐1 (HO‐1) pathway in rats. Both Sita and Cur act against DLM‐prompted serum along with renal tissue biochemical parameters when utilized alone or in a mix alongside DLM intoxication. Besides this, both Sita and Cur delivered synergetic nephroprotective, antioxidative, and anti‐inflammatory impacts. Consequently, it could be presumed that Sita as well as Cur administration can limit the poisonous impacts of DLM by their free radical‐scavenging, strong antioxidant, and Nrf2/HO‐1 pathway upregulation activity.

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Section: Discussionmentioning

confidence: 99%

Curcumin synergistically potentiates the protective effect of sitagliptin against chronic deltamethrin nephrotoxicity in rats: Impact on pro‐inflammatory cytokines and Nrf2/Ho‐1 pathway

Shi

Zhang

Wang

et al. 2019

J Biochem & Molecular Tox

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“…In recent times, it is accounted for to have a wide scope of biological activities, for example, anticancer, pain‐relieving, antihyperglycemic, anti‐inflammatory, antihyperlipidemic, antifertility, cardioprotective, anticonvulsant, wound healing, and antioxidative properties. [ 12–15 ] A broad literature survey, however, reveals no reported scientific proof of embelin role in lung damage.…”

Section: Introductionmentioning

confidence: 99%

Embelin impact on paraquat‐induced lung injury through suppressing oxidative stress, inflammatory cascade, and MAPK/NF‐κB signaling pathway

Sreeharsha

2020

J Biochem & Molecular Tox

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The current examination was intended to observe the defensive impacts of embelin against paraquat‐incited lung damage in relationship with its antioxidant and anti‐inflammatory action. Oxidative stress marker, like malondialdehyde (MDA), antioxidative enzymes, for example, superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH Px), inflammatory cytokines, such as interleukin‐1β (IL‐1β), tumor necrosis factor‐α, and IL‐6, histological examination, and nuclear factor kappa B/mitogen‐activated protein kinase (NF‐κB/MAPK) gene expression were evaluated in lung tissue. Embelin treatment significantly decreased MDA and increased SOD, CAT, and GSH Px. Embelin significantly reduced levels of inflammatory cytokines in paraquat‐administered and paraquat‐intoxicated rats. In addition, embelin suggestively decreased relative protein expression of nuclear NF‐κB p65, p‐NF‐κBp65, p38 MAPK, and p‐p38 MAPKs in paraquat‐intoxicated rats. The outcomes show the impact of embelin inhibitory action on NF‐κB and MAPK and inflammatory cytokines release, and the decrease of lung tissue damage caused by paraquat.

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“…The association of miRNA‐21 expression with the acquired resistance to EGFR‐TKIs in NSCLC cell lines, animal models, and advanced NSCLC patients (Gupta et al, ; Hatware et al, ; Li et al, ). We found with various different studies that upregulation of miR‐21 and downregulation of Pten in 47 NSCLC tumor tissues compared with their adjacent normal tissues and that their expression levels negatively correlated (Chellappan et al, ; Dua et al, ; Gautam, Sharma, Sharma, & Gupta, ). miRNA‐21 expression correlated with shorter DFS in the 47 NSCLC patients.…”

Section: Role Of Micro Rna‐21 In Non‐small‐cell Lung Adenocarcinomamentioning

confidence: 55%

Angiotensin II‐induced micro RNA‐21 culprit for non‐small‐cell lung adenocarcinoma

Luan

Liu

Shi³

2019

Drug Development Research

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Lung cancer is among the most complicated cancers, with an estimated 1.6 million deaths each year for both men and women. However, the proportion of lung cancer patients in developing nations has increased from 31% to 49.9% in the last two decades. There are two main subtypes of lung cancer, small‐cell lung carcinoma and non‐small‐cell lung carcinoma (NSCLC), accounting for 15% and 85% of all lung cancer, respectively. Adenocarcinoma is the most common type of lung cancer in smokers and nonsmokers in men and women regardless of their age. Chemicals in cigarette smoke and nicotine enter our bloodstream and can then affect the entire body and finally lead to the activation of several important, pro‐survival signaling pathways. The biologically active peptide of RAAS on overstimulation enhance Ang II mediates cell proliferation, fibrosis and inflammatory effects via AT1 receptor. Very few studies highlight the diagnostic and therapeutic potential of miRNAs with the EGFR‐regulated miRNA‐21.

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The role of bevacizumab on tumour angiogenesis and in the management of gynaecological cancers: A review

Cited by 41 publications

References 197 publications

Curcumin synergistically potentiates the protective effect of sitagliptin against chronic deltamethrin nephrotoxicity in rats: Impact on pro‐inflammatory cytokines and Nrf2/Ho‐1 pathway

Curcumin synergistically potentiates the protective effect of sitagliptin against chronic deltamethrin nephrotoxicity in rats: Impact on pro‐inflammatory cytokines and Nrf2/Ho‐1 pathway

Embelin impact on paraquat‐induced lung injury through suppressing oxidative stress, inflammatory cascade, and MAPK/NF‐κB signaling pathway

Angiotensin II‐induced micro RNA‐21 culprit for non‐small‐cell lung adenocarcinoma

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