The Role of Bacterial and Fungal Human Respiratory Microbiota in COVID-19 Patients

Soltani, Saber; Zakeri, Armin; Zandi, Milad; Kesheh, Mina Mobini; Tabibzadeh, Alireza; Dastranj, Mahsa; Faramarzi, Samireh; Didehdar, Mojtaba; Hafezi, Hossein; Hosseini, Parastoo; Farahani, Abbas

doi:10.1155/2021/6670798

Cited by 45 publications

(49 citation statements)

References 160 publications

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“…The cumulative results in our study demonstrated that PCV3 trend to low pathogenicity. Whether the synergy between PCV3 and bacterial/viral coinfections warrants further investigation [ 44 , 45 ].…”

Section: Resultsmentioning

confidence: 99%

Pathogenic Characterization of a Porcine Circovirus Type 3 Isolate from Heilongjiang, China

Wang

et al. 2021

Disease Markers

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The clinical outcome of porcine circovirus 3 (PCV3) infection is still controversial. Herein, a novel PCV3 isolate (PCV3-China/DB-1/2017) with the molecular characterization of 24A and 27K in the Cap protein was used to inoculate three-week-old cesarean-derived, colostrum-deprived piglets. The nine PCV3 DB-1 inoculated piglets exhibited no obvious clinical symptoms or macroscopic lesions. PCV3 displayed a broad histotropism, including the heart, liver, spleen, lung, kidney, brain, lymph nodes, and tonsil, and the lungs and lymph nodes contained a higher quantity of viral genomes compared to that of the other organs. From 7 days after PCV3 DB-1 inoculation, the piglets showed obvious IgG antibody responses against PCV3 rCap-VLPs. The cumulative results demonstrated that PCV3 trend to low pathogenicity.

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Section: Resultsmentioning

confidence: 99%

Pathogenic Characterization of a Porcine Circovirus Type 3 Isolate from Heilongjiang, China

Wang

et al. 2021

Disease Markers

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“…Second, we tend to calculate the pooled prevalence based on WHO territorial office data and perform spatial analysis in several geographical districts to distinguish the high-risk area for viral coinfection [68][69][70][71][72][73][74][75][76], but this estimation may be unreliable because of the small number of studies.…”

Section: Discussionmentioning

confidence: 99%

Viral Coinfection among COVID-19 Patient Groups: An Update Systematic Review and Meta-Analysis

Malekifar

Pakzad

Shahbahrami

et al. 2021

BioMed Research International

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Background. Coinfections have a potential role in increased morbidity and mortality rates during pandemics. Our investigation is aimed at evaluating the viral coinfection prevalence in COVID-19 patients. Methods. We systematically searched scientific databases, including Medline, Scopus, WOS, and Embase, from December 1, 2019, to December 30, 2020. Preprint servers such as medRxiv were also scanned to find other related preprint papers. All types of studies evaluating the viral coinfection prevalence in COVID-19 patients were considered. We applied the random effects model to pool all of the related studies. Results. Thirty-three studies including 10484 patients were identified. The viral coinfection estimated pooled prevalence was 12.58%; 95% CI: 7.31 to 18.96). Blood viruses (pooled prevalence: 12.48%; 95% CI: 8.57 to 16.93) had the most frequent viral coinfection, and respiratory viruses (pooled prevalence: 4.32%; 95% CI: 2.78 to 6.15) had less frequent viral coinfection. The herpesvirus pooled prevalence was 11.71% (95% CI: 3.02 to 24.80). Also, the maximum and minimum of viral coinfection pooled prevalence were in AMRO and EMRO with 15.63% (95% CI: 3.78 to 33.31) and 7.05% (95% CI: 3.84 to 11.07), respectively. Conclusion. The lowest rate of coinfection belonged to respiratory viruses. Blood-borne viruses had the highest coinfection rate. Our results provide important data about the prevalence of blood-borne viruses among COVID-19 patients which can be critical when it comes to their treatment procedure.

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“…In the search of answer to the question of why this respiratory virus could affect humans in such a different way, the role of respiratory microbiota has been put on the spot. A very recent review about the role of respiratory microbiota in COVID-19 patients ( 95 ) concluded, based on previous evidence, that the dysbiosis in the microbiota in COVID-19 patients would potentially lead to infection or progression of the disease. However, studies on the characteristics of microbiome in COVID-19 patients are still scarce and conducted in a small number of patients to make them suitable for extrapolating conclusions ( 80 , 96 ).…”

Section: Nasopharyngeal Microbiome and Respiratory Diseasementioning

confidence: 99%

Related Factors to Streptococcus pneumoniae Invasive Infection and Clinical Manifestations: The Potential Role of Nasopharyngeal Microbiome

et al. 2021

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Infections of the lower respiratory tract, such as pneumonia, are one of the leading causes of death worldwide. Streptococcus pneumoniae might colonize the upper respiratory tract and is the main aetiological agent of community-acquired pneumonia (CAP). In the last decades, several factors related to the host, the microorganism and the antibiotic therapy have been investigated to identify risk factors associated with the development of invasive pneumococcal disease (IPD). Nevertheless, these factors themselves do not explain the risk of developing disease or its severity. Recently, some studies have focused on the importance of nasopharyngeal (NP) microbiome and its relation to respiratory health. This review presents existing evidence of the potential role of NP microbiome in the development of IPD.

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The Role of Bacterial and Fungal Human Respiratory Microbiota in COVID-19 Patients

Cited by 45 publications

References 160 publications

Pathogenic Characterization of a Porcine Circovirus Type 3 Isolate from Heilongjiang, China

Pathogenic Characterization of a Porcine Circovirus Type 3 Isolate from Heilongjiang, China

Viral Coinfection among COVID-19 Patient Groups: An Update Systematic Review and Meta-Analysis

Related Factors to Streptococcus pneumoniae Invasive Infection and Clinical Manifestations: The Potential Role of Nasopharyngeal Microbiome

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