The Role of Bacteria and Its Derived Metabolites in Chronic Pain and Depression: Recent Findings and Research Progress

Li, Shan; Duan, Hua; Wang, Qiaoyan; Yang, Ling; Wang, Xinlei; Luo, Ailin; Yang, Chun

doi:10.1093/ijnp/pyz061

Cited by 61 publications

(78 citation statements)

References 121 publications

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“…Ruminococcaceae at genus and family levels have been found to be depleted in cases of both uni-and bipolar depression [26,27,39,[41][42][43].…”

Section: Discussionmentioning

confidence: 99%

Gut microbiome-wide association study of depression

Radjabzadeh¹,

Bosch²,

Uitterlinden³

et al. 2021

Preprint

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Depression is one of the most poorly understood diseases due to its elusive pathogenesis. There is an urgency to identify molecular and biological mechanisms underlying depression and the gut microbiome is a novel area of interest. In this study we investigated the relation of fecal microbiome diversity and composition with depression in 1,054 from the Rotterdam Study cohort and validated these findings in the Amsterdam HELIUS cohort in 1,539 subjects. Using supervised and unsupervised machine learning approaches, we identified and replicated the association of several microbial genera. We confirm the association of genus Eggerthella, Subdoligranulum, Coprococcus and family Ruminococcaceae and identify novel bacteria including Sellimonas, Lachnoclostridium, Hungatella, Ruminococcaceae (UCG002,UCG003 and UCG005), LachnospiraceaeUCG001, Eubacterium ventriosum and Ruminococcusgauvreauiigroup associated with depression. These bacteria are known to be involved in the synthesis of glutamate, butyrate, serotonin and gamma amino butyric acid (GABA), which are key neurotransmitters for depression. Our study suggests the gut microbiome composition may play a key role in depression.

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“…Ruminococcaceae at genus and family levels have been found to be depleted in cases of both uni-and bipolar depression [26,27,39,[41][42][43].…”

Section: Discussionmentioning

confidence: 99%

Gut microbiome-wide association study of depression

Radjabzadeh¹,

Bosch²,

Uitterlinden³

et al. 2021

Preprint

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“…In the brain, there is evidence that butyrate downregulated lipopolysaccharide-induced neuroinflammation in microglia, a specialized population of immune cells important for neuroprotection and neural remodeling [ 104 ]. Indeed, microbiome composition and SCFA levels have been implicated in the pathogenesis of substance use disorders, Parkinson’s disease and depression [ 107 , 108 , 109 ].…”

Section: Scfa and The Gut–brain Axismentioning

confidence: 99%

Butyrate and the Intestinal Epithelium: Modulation of Proliferation and Inflammation in Homeostasis and Disease

Salvi

Cowles

2021

Cells

171

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The microbial metabolite butyrate serves as a link between the intestinal microbiome and epithelium. The monocarboxylate transporters MCT1 and SMCT1 are the predominant means of butyrate transport from the intestinal lumen to epithelial cytoplasm, where the molecule undergoes rapid β-oxidation to generate cellular fuel. However, not all epithelial cells metabolize butyrate equally. Undifferentiated colonocytes, including neoplastic cells and intestinal stem cells at the epithelial crypt base preferentially utilize glucose over butyrate for cellular fuel. This divergent metabolic conditioning is central to the phenomenon known as “butyrate paradox”, in which butyrate induces contradictory effects on epithelial proliferation in undifferentiated and differentiated colonocytes. There is evidence that accumulation of butyrate in epithelial cells results in histone modification and altered transcriptional activation that halts cell cycle progression. This manifests in the apparent protective effect of butyrate against colonic neoplasia. A corollary to this process is butyrate-induced inhibition of intestinal stem cells. Yet, emerging research has illustrated that the evolution of the crypt, along with butyrate-producing bacteria in the intestine, serve to protect crypt base stem cells from butyrate’s anti-proliferative effects. Butyrate also regulates epithelial inflammation and tolerance to antigens, through production of anti-inflammatory cytokines and induction of tolerogenic dendritic cells. The role of butyrate in the pathogenesis and treatment of intestinal neoplasia, inflammatory bowel disease and malabsorptive states is evolving, and holds promise for the potential translation of butyrate’s cellular function into clinical therapies.

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“…Consequently, dysbiosis has been associated with an increasing list of diseases, which include inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), coeliac disease and colorectal cancer (CRC) [ 3 ]. Additionally, several extra-intestinal disorders such as asthma [ 4 ], systemic lupus erythematosus [ 5 ], cardiovascular disease [ 6 ] or even mental and neurodegenerative diseases including autism, anxiety, depression, chronic pain, Parkinson’s, Alzheimer’s or Huntington’s can be linked to a dysfunctional gut microbiota [ 7 , 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Impact of Phlorotannin Extracts from Fucus vesiculosus on Human Gut Microbiota

et al. 2021

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Recent studies indicate that plant polyphenols could be pointed as potential prebiotic candidates since they may interact with the gut microbiota, stimulating its growth and the production of metabolites. However, little is known about the fate of brown seaweeds’ phlorotannins during their passage throughout the gastrointestinal tract. This work aimed to evaluate the stability and bioaccessibility of Fucus vesiculosus phlorotannins after being submitted to a simulated digestive process, as well as their possible modulatory effects on gut microbiota and short-chain fatty acids production following a fermentation procedure using fecal inoculates to mimic the conditions of the large intestine. The stability of phlorotannins throughout the gastrointestinal tract was reduced, with a bioaccessibility index between 2 and 14%. Moreover, slight alterations in the growth of certain commensal bacteria were noticed, with Enterococcus spp. being the most enhanced group. Likewise, F. vesiculosus phlorotannins displayed striking capacity to enhance the levels of propionate and butyrate, which are two important short-chain fatty acids known for their role in intestinal homeostasis. In summary, this work provides valuable information regarding the behavior of F. vesiculosus phlorotannins along the gastrointestinal tract, presenting clear evidence that these compounds can positively contribute to the maintenance of a healthy gastrointestinal condition.

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The Role of Bacteria and Its Derived Metabolites in Chronic Pain and Depression: Recent Findings and Research Progress

Cited by 61 publications

References 121 publications

Gut microbiome-wide association study of depression

Gut microbiome-wide association study of depression

Butyrate and the Intestinal Epithelium: Modulation of Proliferation and Inflammation in Homeostasis and Disease

Impact of Phlorotannin Extracts from Fucus vesiculosus on Human Gut Microbiota

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