The Role of Autophagy in Hepatocellular Carcinoma

Lee, Yoo Jin; Jang, Byoung Kuk

doi:10.3390/ijms161125984

Cited by 85 publications

(99 citation statements)

References 132 publications

(163 reference statements)

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“…Recent studies also demonstrated that autophagy was involved in inflammatory diseases as well as cancers . Autophagy played a dual role in the development of HCC by suppressing tumor initiation and promoting subsequent tumor growth . Recently, Li et al reported that IL‐37 treatment could induce the production of autophagosomes and apoptosis in HCC cell lines .…”

Section: Il‐37 In Tumormentioning

confidence: 99%

“…84 Autophagy played a dual role in the development of HCC by suppressing tumor initiation and promoting subsequent tumor growth. 85 Recently, Li et al reported that IL-37 treatment could induce the production of autophagosomes and apoptosis in HCC cell lines. 86 Further study showed that IL-37 triggered HCC cell autophagy by inhibiting PI3K/AKT/mTOR signaling pathway.…”

Section: Hepatocellular Carcinomamentioning

confidence: 99%

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IL‐37: An anti‐inflammatory cytokine with antitumor functions

Liu

2018

Cancer Reports

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Background IL‐37 is a newly identified IL‐1 family cytokine. Unlike other members in IL‐1 family, IL‐37 has been demonstrated to be an anti‐inflammatory cytokine in many inflammatory and autoimmune diseases. IL‐37 is regarded as a dual‐function cytokine as both the extracellular and intracellular IL‐37 are biologically functional. Extracellular IL‐37 can bind to IL‐18Rα and IL‐1R8 to form a triple complex, regulating the downstream STAT3 and PTEN signaling. Intracellular IL‐37 can interact with Smad3, translocate into nucleus, and regulate downstream target gene expressions. Recently, the role of IL‐37 in tumor development has been extensively studied. Recent findings IL‐37 has been found to play an antitumor role in various types of tumors, such as non‐small cell lung cancer, hepatocellular carcinoma, and renal cell carcinoma. Many mechanism studies have been carried out to elaborate the possible effects of IL‐37 on tumor growth, immune responses, and tumor angiogenesis. More importantly, the function of IL‐37 may be dependent on its concentration and receptor expression. It can form dimers at high concentrations to be inactivated, thus inhibiting its anti‐inflammatory function. We focused on the role of IL‐37 in various tumor types and provided the hypothesis regarding the underlying mechanisms. Conclusion IL‐37 may affect tumor development through multiple mechanisms: (1) IL‐37 directly influences tumor cell viability; (2) IL‐37 regulates the immune response to promote the antitumor immunity; and (3) IL‐37 suppresses tumor angiogenesis in the tumor microenvironment. Future studies are warranted to further investigate the mechanisms of these multifaceted functions of IL‐37 in animal models and cancer patients.

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Section: Il‐37 In Tumormentioning

confidence: 99%

Section: Hepatocellular Carcinomamentioning

confidence: 99%

IL‐37: An anti‐inflammatory cytokine with antitumor functions

Liu

2018

Cancer Reports

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“…It is mediated by a rearrangement of subcellular membranes that results in the envelopment of cytosol or organelles for delivery into lysosomes, where the enveloped cargo is digested and recycled [52][53][54].…”

Section: Types Of Autophagymentioning

confidence: 99%

Autophagy: A double-edged sword in intervertebral disk degeneration

Zhang

Yang

Wang

et al. 2016

Clinica Chimica Acta

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“…Once HCC has developed in autophagy-competent rat livers, diferences in autophagy patern correlate with aggressiveness of the tumours, as determined by the marker cytokeratin-19 [135]. For further extensive discussion of the role s of autophagy in liver tumour biology, we refer to other published reviews [ 1,136].…”

Section: Autophagy and Hepatocellular Injury And Hepatocellular Carmentioning

confidence: 99%

Autophagy in Non-Alcoholic Fatty Liver Disease (NAFLD)

Kwanten¹,

Martinet²,

Francque³

2016

Autophagy in Current Trends in Cellular Physiology and Pathology

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Abstract"utophagy is a mechanism involved in cellular homeostasis under basal and stressed conditions delivering cytoplasmic content to the lysosomes for degradation to macronutrients. The potential role of autophagy in disease is increasingly recognised and investigated. To date, a key role of autophagy in hepatic lipid metabolism is recognised and dysfunctional autophagy might be an underlying cause of non-alcoholic faty liver disease N"FLD . Nevertheless, the exact role of autophagy in lipid metabolism remains controversial, with both a lipolytic function of autophagy and lipogenic function reported. This chapter aims to review the current knowledge on autophagy in N"FLD, with a special focus on its role in hepatic lipid metabolism, hepatic glucose metabolism and insulin resistance, steatohepatitis, hepatocellular injury and hepatic ibrogenesis. Finally, interaction with another cellular homeostatic process, the unfolded protein response UPR , will be briely discussed.

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The Role of Autophagy in Hepatocellular Carcinoma

Cited by 85 publications

References 132 publications

IL‐37: An anti‐inflammatory cytokine with antitumor functions

IL‐37: An anti‐inflammatory cytokine with antitumor functions

Autophagy: A double-edged sword in intervertebral disk degeneration

Autophagy in Non-Alcoholic Fatty Liver Disease (NAFLD)

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