The role of autophagy in the pathogenesis of SARS-CoV-2 infection in different cell types

Samimi, Nastaran; Klionsky, Daniel J.; Rezaei, Nima

doi:10.1080/15548627.2021.1989150

Cited by 13 publications

(30 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Due to its dependence on the host response and its indirect measurement of SARS-CoV-2 infection and replication, the CPE assay may have certain limitations. The phenotypic outcome can also vary depending on culture conditions, the viral multiplicity of infection (MOI), and the number of virions added per cell during infection [43][44][45].…”

Section: Phenotypic Screeningmentioning

confidence: 99%

A Comprehensive Review of Drug Repurposing Strategies against Known Drug Targets of COVID-19

Khataniar

Pathak

Rajkhowa

et al. 2022

COVID

View full text Add to dashboard Cite

Drug repurposing is a more inexpensive and shorter approach than the traditional drug discovery and development process. The concept of identifying a potent molecule from a library of pre-existing molecules or an already approved drug has become a go-to tactic to accelerate the identification of drugs that can prevent COVID-19. This seemingly uncontrollable disease is caused by SARS-CoV-2. It is a novel virus of the Betacoronavirus genus, exhibiting similarities to the previously reported SAR-CoV genome structure and viral pathogenesis. The emergence of SARS-CoV-2 and the rapid outbreak of COVID-19 have resulted in a global pandemic. Researchers are hard-pressed to develop new drugs for total containment of the disease, thus making the cost-effective drug repurposing a much more feasible approach. Therefore, the current review attempts to collate both the experimental and computational drug repurposing strategies that have been utilized against significant drug targets of SARS-CoV-2. Along with the strategies, the available druggable targets shall also be discussed. However, the occurrence of frequent recombination of the viral genome and time-bound primary analysis, resulting in insignificant data, are two major challenges that drug repurposing still faces.

show abstract

Section: Phenotypic Screeningmentioning

confidence: 99%

A Comprehensive Review of Drug Repurposing Strategies against Known Drug Targets of COVID-19

Khataniar

Pathak

Rajkhowa

et al. 2022

COVID

View full text Add to dashboard Cite

show abstract

“…For example, during virus infection, autophagy contributes to major histocompatibility complex class Ι and II (MHC-I and MHC-II) antigen presentation by facilitating viral antigen processing and transport 28 , 29 . Autophagy also regulates cytokine production, inflammation and cell survival to defend against virus invasion 20 , 30 , 31 , 32 .…”

Section: Dual Functions Of Autophagy During Positive-stranded Rna Vir...mentioning

confidence: 99%

Autophagy in severe acute respiratory syndrome coronavirus 2 infection

Chen

Zhang

2022

Current Opinion in Physiology

View full text Add to dashboard Cite

“…Together with electron tomography, an interconnected DMV network can be observed following SARS-CoV-2 infection, with DMVs connected to the ER through ER connectors (Cortese et al, 2020). The virus actually hijacks the autophagy machinery (Samimi et al, 2021) in order to create these DMVs, which are used as replication organelles (Twu et al, 2021). The Golgi apparatus, which appears to be fragmented, is the viral assembly site and is involved in budding events (Cortese et al, 2020).…”

Section: Viral Replicationmentioning

confidence: 99%

Imaging Techniques: Essential Tools for the Study of SARS-CoV-2 Infection

Deroubaix

Kramvis²

2022

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

The world has seen the emergence of a new virus in 2019, SARS-CoV-2, causing the COVID-19 pandemic and millions of deaths worldwide. Microscopy can be much more informative than conventional detection methods such as RT-PCR. This review aims to present the up-to-date microscopy observations in patients, the in vitro studies of the virus and viral proteins and their interaction with their host, discuss the microscopy techniques for detection and study of SARS-CoV-2, and summarize the reagents used for SARS-CoV-2 detection. From basic fluorescence microscopy to high resolution techniques and combined technologies, this article shows the power and the potential of microscopy techniques, especially in the field of virology.

show abstract

The role of autophagy in the pathogenesis of SARS-CoV-2 infection in different cell types

Cited by 13 publications

References 36 publications

A Comprehensive Review of Drug Repurposing Strategies against Known Drug Targets of COVID-19

A Comprehensive Review of Drug Repurposing Strategies against Known Drug Targets of COVID-19

Autophagy in severe acute respiratory syndrome coronavirus 2 infection

Imaging Techniques: Essential Tools for the Study of SARS-CoV-2 Infection

Contact Info

Product

Resources

About