The role of autonomic cardiovascular neuropathy in pathogenesis of ischemic heart disease in patients with diabetes mellitus

Popović-Pejičić, Snježana; Todorović-Dilas, L; Pantelinac, Pavle

doi:10.2298/mpns0604118p

Cited by 3 publications

(2 citation statements)

References 5 publications

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“…Prasad et al studied cardiac autonomic dysfunction and ECG abnormalities in patients with Type II diabetes and found increased frequency of postural hypotension in patients with diabetes compared to healthy controls. Finding of the present study is in accordance with studies done by Jayabal et al [4] and Prasad et al [5] studies done in the past by Ewing et al, [6] Dyrberg et al, [7] Popovic et al, [8] Beylot et al, [9] and Barkai and Madacsy [10] had similar results. It can thus be concluded that the heart rate response to standing, a measure of cardiac parasympathetic function is reduced in uncontrolled diabetes patient groups compared to controls.…”

Section: Jayabal Et Al Studied Autonomic Function Test In Patients Withsupporting

confidence: 93%

Study of cardiovascular responses to sustained handgrip and change in posture in Type II diabetes mellitus patients

Suhail¹,

Hatekar²,

Daimi³

et al. 2017

Natl J Physiol Pharm Pharmacol

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Background: In India, more than 50% of patients with Type II diabetes have poor glycemic control and these patients suffer from complications of diabetes. One of the major complications of diabetes is impaired cardiovascular autonomic reflexes. Postural tachycardia index, blood pressure (BP) response to sustained handgrip (SHG), and BP response to standing these tests are used to assess cardiovascular autonomic responses. Aims and Objectives: This study was done to assess cardiovascular responses to SHG and change in posture in Type II diabetes mellitus patients. Materials and Methods: A total of 90 participants were selected out, of which 30 participants had uncontrolled diabetes, 30 had controlled diabetes, and remaining were 30 age-and gender-matched healthy controls. Postural tachycardia index, BP response to SHG, and BP response to standing were measured using Physiopac-8: Computerized 8-channel biopotential acquisition system and Omron Intellisense M3 BP monitor. Data obtained were analyzed statistically. Results: Postural tachycardia index values were significantly lower in uncontrolled diabetes patient group as compared to controlled diabetes patient group and healthy control group. The value of BP response to sustained handgrip in uncontrolled diabetes patient group was significantly lower as compared to healthy controls (P < 0.01), whereas no statistically significant difference observed between uncontrolled and controlled diabetes patient groups (P = 0.35). The value of BP response to standing was significantly higher in uncontrolled diabetes patient group as compared healthy controls (P < 0.01), there is a progressive increase in value of fall of BP to standing from healthy control group to uncontrolled diabetes patient group. Value of fall in BP is more in both controlled and uncontrolled diabetes patient group compared to controls but value is greater in patients with uncontrolled diabetes. Conclusion: Poor glycemic control leads to impairment of cardiovascular response to change in posture and SHG in Type II diabetes mellitus patients.

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Section: Jayabal Et Al Studied Autonomic Function Test In Patients Withsupporting

confidence: 93%

Study of cardiovascular responses to sustained handgrip and change in posture in Type II diabetes mellitus patients

Suhail¹,

Hatekar²,

Daimi³

et al. 2017

Natl J Physiol Pharm Pharmacol

View full text Add to dashboard Cite

show abstract

“…genitourinary, and cardiovascular). The latter, diabetic cardiac autonomic neuropathy, is the most serious [12] and is a risk for heart disease [34], cardiovascular events [35] including silent myocardial infarction, stroke [36] and mortality [37].…”

Section: Plos Onementioning

confidence: 99%

Household food insecurity is associated with greater autonomic dysfunction testing score in Latinos with type 2 diabetes

Bermúdez-Millán,

Feinn,

Lampert

et al. 2024

PLoS ONE

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Aim We examined household food insecurity (HFI) and autonomic nervous system (ANS) function in a subset of low-income Latinos with type 2 diabetes with data from a stress management trial. Methods Inclusion Latino or Hispanic, Spanish speaking, age less than 18 years, ambulatory status, type 2 diabetes more than 6 months, A1c less than 7.0%. Exclusion Pain or dysfunction in hands (e.g., arthritis) precluding handgrip testing; medical or psychiatric instability. HFI was assessed with the 6-item U.S. household food security survey module; with responses to > = 1 question considered HFI. An ANS dysfunction index was calculated from xix autonomic function tests which were scored 0 = normal or 1 = abnormal based on normative cutoffs and then summed. Autonomic function tests were: 1) 24-hour heart rate variability as reflected in standard deviation of the normal-to-normal (SDNN) heart rate acquired with 3-channel, 7-lead ambulatory electrocardiogram (Holter) monitors; 2) difference between the highest diastolic blood pressure (DBP) during sustained handgrip and the average DBP at rest; 3) difference between baseline supine and the minimal BP after standing up; and, from 24-hour urine specimens 4) cortisol, 5) normetanephrine, and, 6) metanephrine. Results Thirty-five individuals participated, 23 (65.7%) of them were women, age mean = 61.6 (standard deviation = 11.2) years, HbA1c mean = 8.5% (standard deviation = 1.6) and 20 participants (57.1%) used insulin. Twenty-two participants (62.9%) reported HFI and 25 (71.4%) had one or more abnormal ANS measure. Independent t-tests showed that participants with HFI had a higher ANS dysfunction index (mean = 1.5, standard deviation = 0.9) than patients who were food secure (mean = 0.7, standard deviation = 0.8), p = 0.02. Controlling for financial strain did not change significance. Total ANS index was not related to glycemia, insulin use or other socioeconomic indicators. In this sample, HFI was associated with ANS dysfunction. Policies to improve food access and affordability may benefit health outcomes for Latinos with diabetes.

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Cardiovascular disease and risk factors in patients with type 2 diabetes mellitus in Mashhad, Islamic Republic of Iran

Bonakdaran

Ebrahimzadeh²,

Sh³

2011

East Mediterr Health J

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The aim of this study in 2006-08 was to determine the prevalence and risk factors of CVD in an Iranian population of patients with type 2 diabetes mellitus. History and physical examinations were recorded and laboratory tests were performed in 752 patients attending the Mashhad Endocrine and Metabolism Research Center. The prevalence of CVD was 20.1%. CVD was significantly associated with age, duration of diabetes, hypertension, diabetic retinopathy, metabolic syndrome, renal insufficiency, triglycerides, high-density lipoprotein (HDL) cholesterol, uric acid and triglycerides/HDL ratio. Using a logistic regression model, age, metabolic syndrome and HDL cholesterol were significant independent predictors of CVD. The high prevalence of CVD in Iranian patients with type 2 diabetes underscores the importance of better detection and treatment of metabolic risk factors of CVD in these patients.

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The role of autonomic cardiovascular neuropathy in pathogenesis of ischemic heart disease in patients with diabetes mellitus

Abstract: Cardiovascular autonomic neuropathy is a common complication of diabetes that significantly correlates with coronary disease. Early diagnosis of cardiovascular autonomic neuropathy points to increased cardiovascular risk, providing a basis for preventive and therapeutic measures.

Cited by 3 publications

References 5 publications

Study of cardiovascular responses to sustained handgrip and change in posture in Type II diabetes mellitus patients

Study of cardiovascular responses to sustained handgrip and change in posture in Type II diabetes mellitus patients

Household food insecurity is associated with greater autonomic dysfunction testing score in Latinos with type 2 diabetes

Cardiovascular disease and risk factors in patients with type 2 diabetes mellitus in Mashhad, Islamic Republic of Iran

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