The role of ATP-dependent potassium channels and nitric oxide system in the neuroprotective effect of preconditioning

Deryagin, Oleg; Гаврилова, С.А.; Buravkov, S. V.; Андрианов, В. В.; Yafarova, G. G.; Гайнутдинов, Х. Л.; Koshelev, V. B.

doi:10.17116/jnevro20161168217-23

Cited by 6 publications

(3 citation statements)

References 24 publications

(22 reference statements)

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“…Ischemic infarction in the fronto-parietal region of cerebral cortex was induced by electrocoagulation of the distal branch of left MCA and the adjacent vein, with simultaneous ligation of the ipsilateral carotid artery. This model of ischemic stroke was chosen because of its good reproducibility in experiments which demonstrated a 30–45% decrease of necrotic area after IP or PhP (Samoilenkova et al, 2007 ; Deryagin et al, 2016 ). The MCA coagulation altitude was chosen so that necrosis developed mainly in the frontoparietal cortex, without affecting subcortical structures, thereby avoiding complications of visceral functions and animal death.…”

Section: Methodsmentioning

confidence: 99%

Molecular Bases of Brain Preconditioning

et al. 2017

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Preconditioning of the brain induces tolerance to the damaging effects of ischemia and prevents cell death in ischemic penumbra. The development of this phenomenon is mediated by mitochondrial adenosine triphosphate-sensitive potassium (KATP+) channels and nitric oxide signaling (NO). The aim of this study was to investigate the dynamics of molecular changes in mitochondria after ischemic preconditioning (IP) and the effect of pharmacological preconditioning (PhP) with the KATP+-channels opener diazoxide on NO levels after ischemic stroke in rats. Immunofluorescence-histochemistry and laser-confocal microscopy were applied to evaluate the cortical expression of electron transport chain enzymes, mitochondrial KATP+-channels, neuronal and inducible NO-synthases, as well as the dynamics of nitrosylation and nitration of proteins in rats during the early and delayed phases of IP. NO cerebral content was studied with electron paramagnetic resonance (EPR) spectroscopy using spin trapping. We found that 24 h after IP in rats, there is a two-fold decrease in expression of mitochondrial KATP+-channels (p = 0.012) in nervous tissue, a comparable increase in expression of cytochrome c oxidase (p = 0.008), and a decrease in intensity of protein S-nitrosylation and nitration (p = 0.0004 and p = 0.001, respectively). PhP led to a 56% reduction of free NO concentration 72 h after ischemic stroke simulation (p = 0.002). We attribute this result to the restructuring of tissue energy metabolism, namely the provision of increased catalytic sites to mitochondria and the increased elimination of NO, which prevents a decrease in cell sensitivity to oxygen during subsequent periods of severe ischemia.

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Section: Methodsmentioning

confidence: 99%

Molecular Bases of Brain Preconditioning

et al. 2017

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“…It can damage nerve cells and increase cell membrane permeability, leading to brain edema and postoperative cognitive dysfunction [21,22]. Several previous studies have suggested that mitochondrial ATP-sensitive potassium channels play an important role in this process [23][24][25]. Brain edema and nerve tissue degeneration may indicate cognitive impairment.…”

Section: Discussionmentioning

confidence: 99%

Clinical characteristics of postoperative cognitive dysfunction after local balloon compression for trigeminal neuralgia: a retrospective study

Luo

Liu

et al. 2023

Preprint

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Purpose To identify the high-risk population of trigeminal neuralgia (TN) with postoperative cognitive dysfunction, reduce the consequent long-term postoperative complications, and improve the postoperative quality of life. Methods A retrospective study was conducted among 94 TN patients that underwent percutaneous balloon compression in the Affiliated Huai 'an First People's Hospital of Nanjing Medical University from 2017 to 2022. Patients were divided according to the post- Mini-Mental State Examimation (MMSE) scores (postoperative cognitive dysfunction and postoperative cognitive function normal groups). General information, past medical history, laboratory examination, treatment methods, self rating anxiety scale (SAS) score, visual analog scale (VAS) score and MMSE score were collected. Results Total 21 patients developed postoperative cognitive impairment, of which 16 were transient, and 3 were prolonged. Postoperative cognitive impairment prolonged the hospital stay (p< 0.001). Advanced age (p = 0.028), high preoperative SAS score (p < 0.001), and prolonged anesthesia duration (p < 0.032) were independent risk factors for surgical patients of TN. Three patients in the postoperative cognitive dysfunction group showed brain swelling and extensive white matter degeneration in the frontal and parietal lobes. Eight patients were treated with hyperbaric oxygen (HBO), following which, the MMSE score was significantly higher (p < 0.05) than that in the group without HBO, with no long-term complications. Preoperative SAS score was negatively correlated with the postoperative MMSE score (R = 0.3541, p < 0.001). Conclusion Postoperative cognitive dysfunction prolongs hospital stay in patients with TN. Functional magnetic resonance imaging can reflect brain tissue damage, and HBO therapy helps in postoperative cognitive function recovery.

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“…Neuroimmune molecular responses linked to conditioning include innate immune signaling pathways such as Toll-like receptors (TLRs) and type 1 interferons (122). Intracellularly, many kinases and signaling factors known to be important in smooth muscles have been identified, including heme oxygenase-1, nitric oxide (NO), HIF, VEGF, ATPsensitive K ϩ (K ATP ) channels, prostaglandins, bradykinin, PKC, PKG, and ROS as well as stromal derived factor-1␣ and microRNA-144 (3,25,44,45,85,132,150,202).…”

Section: Current Synthesismentioning

confidence: 99%

Hypoxic conditioning in blood vessels and smooth muscle tissues: effects on function, mechanisms, and unknowns

AlMohanna

Wray

2018

American Journal of Physiology-Heart and Circulatory Physiology

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Hypoxic preconditioning, the protective effect of brief, intermittent hypoxic or ischemic episodes on subsequent more severe hypoxic episodes, has been known for 30 yr from studies on cardiac muscle. The concept of hypoxic preconditioning has expanded; excitingly, organs beyond the heart, including the brain, liver, and kidney, also benefit. Preconditioning of vascular and visceral smooth muscles has received less attention despite their obvious importance to health. In addition, there has been no attempt to synthesize the literature in this field. Therefore, in addition to overviewing the current understanding of hypoxic conditioning, in the present review, we consider the role of blood vessels in conditioning and explore evidence for conditioning in other smooth muscles. Where possible, we have distinguished effects on myocytes from other cell types in the visceral organs. We found evidence of a pivotal role for blood vessels in conditioning and for conditioning in other smooth muscle, including the bladder, vascular myocytes, and gastrointestinal tract, and a novel response in the uterus of a hypoxic-induced force increase, which helps maintain contractions during labor. To date, however, there are insufficient data to provide a comprehensive or unifying mechanism for smooth muscles or visceral organs and the effects of conditioning on their function. This also means that no firm conclusions can be drawn as to how differences between smooth muscles in metabolic and contractile activity may contribute to conditioning. Therefore, we have suggested what may be general mechanisms of conditioning occurring in all smooth muscles and tabulated tissue-specific mechanistic findings and suggested ideas for further progress.

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The role of ATP-dependent potassium channels and nitric oxide system in the neuroprotective effect of preconditioning

Cited by 6 publications

References 24 publications

Molecular Bases of Brain Preconditioning

Molecular Bases of Brain Preconditioning

Clinical characteristics of postoperative cognitive dysfunction after local balloon compression for trigeminal neuralgia: a retrospective study

Hypoxic conditioning in blood vessels and smooth muscle tissues: effects on function, mechanisms, and unknowns

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