The role of astrocytes in the nucleus tractus solitarii in maintaining central control of autonomic function

Martínez, Diana; Kline, David D.

doi:10.1152/ajpregu.00254.2020

Cited by 14 publications

(12 citation statements)

References 87 publications

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“…In addition to astrocytes, microglia and oligodendrocytes express neurotransmitter receptors and microglia in the NTS are altered in response to varied stimuli, including removal of vagal input 83 (rat), obesity 88 (rat), and hypoxia 89 (mouse). A detailed discussion of NTS glial function is beyond the scope of this review, and readers are referred to a recent comprehensive review on the subject 5,90,91 …”

Section: Cell Types Of the Cntsmentioning

confidence: 99%

The ins and outs of the caudal nucleus of the solitary tract: An overview of cellular populations and anatomical connections

Holt

2022

J Neuroendocrinology

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Section: Cell Types Of the Cntsmentioning

confidence: 99%

The ins and outs of the caudal nucleus of the solitary tract: An overview of cellular populations and anatomical connections

Holt

2022

J Neuroendocrinology

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“…We focus our review on energy balance, although we are aware that at the brainstem level, neuroglial interactions interfere with other autonomic functions, particularly cardiorespiratory function. Nonetheless, this field has already been discussed in recent reviews [5,7]. Here, we describe the structural organization and diversity of DVC glial cells and their contributions to: (i) glucodetection and associated responses; (ii) the integration of viscerosensory signals; and (iii) the modulation of food intake.…”

Section: Introductionmentioning

confidence: 89%

“…Interestingly, alterations in extracellular glutamate buffering can result from astrocyte process retraction. This phenomenon may occur in several circumstances in the NTS owing to the high morphofunctional plasticity of NTS astroglial coverage (reviewed in [7,30]). The depolarization and action potential firing recorded in NTS neurons following pan-EAAT inhibition by threo-beta-benzyloxyaspartate (TBOA; [82]) or the selective inhibition of EAAT2 by dihydrohainate (DHK; [83,84]) can predict the consequences of reduced astroglial synapse ensheathment.…”

Section: Integration Of Viscerosensory Signals: Regulation By Nts Ast...mentioning

confidence: 99%

Glial Modulation of Energy Balance: The Dorsal Vagal Complex Is No Exception

Troadec

Gaigé

Barbot

et al. 2022

IJMS

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The avoidance of being overweight or obese is a daily challenge for a growing number of people. The growing proportion of people suffering from a nutritional imbalance in many parts of the world exemplifies this challenge and emphasizes the need for a better understanding of the mechanisms that regulate nutritional balance. Until recently, research on the central regulation of food intake primarily focused on neuronal signaling, with little attention paid to the role of glial cells. Over the last few decades, our understanding of glial cells has changed dramatically. These cells are increasingly regarded as important neuronal partners, contributing not just to cerebral homeostasis, but also to cerebral signaling. Our understanding of the central regulation of energy balance is part of this (r)evolution. Evidence is accumulating that glial cells play a dynamic role in the modulation of energy balance. In the present review, we summarize recent data indicating that the multifaceted glial compartment of the brainstem dorsal vagal complex (DVC) should be considered in research aimed at identifying feeding-related processes operating at this level.

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“…GPR143 has recently been shown to play a role in cardiovascular function through the (NTS) ( Goshima et al, 2014 ; 2019a ). The NTS is a sensory nucleus embedded in the medulla oblongata ( Šimić, 2019 ) that receives signals from the solitary tract including facial, taste, gastrointestinal and cardio-respiratory signals ( Geerling and Loewy, 2006 ; Michael Conn, 2008 ; Zoccal et al, 2014 ; Šimić, 2019 ; Martinez and Kline, 2021 ). Studies by Hiroshima et al .…”

Section: Gpr143 and Diseasesmentioning

confidence: 99%

The Many Faces of G Protein-Coupled Receptor 143, an Atypical Intracellular Receptor

Bueschbell

Manga

Schiedel

2022

Front. Mol. Biosci.

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GPCRs transform extracellular stimuli into a physiological response by activating an intracellular signaling cascade initiated via binding to G proteins. Orphan G protein-coupled receptors (GPCRs) hold the potential to pave the way for development of new, innovative therapeutic strategies. In this review we will introduce G protein-coupled receptor 143 (GPR143), an enigmatic receptor in terms of classification within the GPCR superfamily and localization. GPR143 has not been assigned to any of the GPCR families due to the lack of common structural motifs. Hence we will describe the most important motifs of classes A and B and compare them to the protein sequence of GPR143. While a precise function for the receptor has yet to be determined, the protein is expressed abundantly in pigment producing cells. Many GPR143 mutations cause X-linked Ocular Albinism Type 1 (OA1, Nettleship-Falls OA), which results in hypopigmentation of the eyes and loss of visual acuity due to disrupted visual system development and function. In pigment cells of the skin, loss of functional GPR143 results in abnormally large melanosomes (organelles in which pigment is produced). Studies have shown that the receptor is localized internally, including at the melanosomal membrane, where it may function to regulate melanosome size and/or facilitate protein trafficking to the melanosome through the endolysosomal system. Numerous additional roles have been proposed for GPR143 in determining cancer predisposition, regulation of blood pressure, development of macular degeneration and signaling in the brain, which we will briefly describe as well as potential ligands that have been identified. Furthermore, GPR143 is a promiscuous receptor that has been shown to interact with multiple other melanosomal proteins and GPCRs, which strongly suggests that this orphan receptor is likely involved in many different physiological actions.

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The role of astrocytes in the nucleus tractus solitarii in maintaining central control of autonomic function

Cited by 14 publications

References 87 publications

The ins and outs of the caudal nucleus of the solitary tract: An overview of cellular populations and anatomical connections

The ins and outs of the caudal nucleus of the solitary tract: An overview of cellular populations and anatomical connections

Glial Modulation of Energy Balance: The Dorsal Vagal Complex Is No Exception

The Many Faces of G Protein-Coupled Receptor 143, an Atypical Intracellular Receptor

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