The Role of Assisted Ventilation in Survival After Respiratory Failure in Children With AIDS

Abadco, Douglas L.

doi:10.1001/archpedi.1992.02160210054020

Cited by 2 publications

(3 citation statements)

References 19 publications

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“…18 Infants ventilated for HIV related acute respiratory failure had ICU survival rates of 50-81%. [22][23][24] PCP is the commonest AIDS related disease for which ventilatory support is needed and has the worst outcome. The prognosis is better in the absence of PCP, or in those who had PCP with another associated illness, or in those children where treatment for PCP was instituted less than five days before needing ventilation.…”

Section: Outcome Of Hiv Infected Children Requiring Mechanical Ventilmentioning

confidence: 99%

Challenges in the provision of ICU services to HIV infected children in resource poor settings: a South African case study: Table 1

Jeena

McNally²,

Stobie³

et al. 2005

J Med Ethics

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The HIV/AIDS epidemic has placed increasing demands on limited paediatric intensive care services in developing countries. The decision to admit HIV infected children withPneumocystis cariniipneumonia (PCP) into the paediatric intensive care unit (PICU) has to be made on the best available evidence of outcome and the ethical principles guiding appropriate use of scarce resources. The difficulty in confirming the diagnosis of HIV infection and PCP in infancy, issues around HIV counselling, and the variance in the outcome of HIV infected children with PCP admitted to the PICU in African studies compound this process. Pragmatic decision making will require evaluation of at least three ethical questions: are there clinical and moral reasons for admitting HIV positive children with PCP to the PICU, should more resources be committed to caring for HIV children who require the PICU, and how can we morally choose candidates for the PICU? Those working in the PICU in HIV endemic regions need to make difficult personal decisions on effective triage of admissions of HIV infected children with PCP based on individual case presentation, availability of resources, and applicable ethical principles.

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Section: Outcome Of Hiv Infected Children Requiring Mechanical Ventilmentioning

confidence: 99%

Challenges in the provision of ICU services to HIV infected children in resource poor settings: a South African case study: Table 1

Jeena

McNally²,

Stobie³

et al. 2005

J Med Ethics

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“…The treatment of hepatitis C is not successful in most cases; furthermore, it is a very expensive and time consuming procedure, to this purpose, we as well as other researchers are interested to develop an HCV vaccine to prevent the infection [11][12]. HCV core protein was considered as immunogenic counterpart of the vaccine.…”

Section: Introductionmentioning

confidence: 99%

“…Due to contribution of all amino acid residues of the molecule to make perfect conformational epitopes, total of 191 amino acids of the molecule were included in the vaccine preparation in this study. The mentioned characteristics of the core protein and the conservative feature of the core gene in different HCV genotypes and the low susceptible of mutation in this region, make this protein an ideal candidate for HCV vaccine [12][13][14][15][16][17][18]…”

Section: Introductionmentioning

confidence: 99%

The Evaluation of Hepatitis C Virus Core Antigen in Immunized Balb/C Mice

Torbati

Bandehpour²,

Pakzad

et al. 2012

Hepat Mon

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Background Hepatitis infection represents one of the important causes of morbidity and mortality in developing countries, however there is not any effective vaccine against hepatitis C which is one of the significant problems in vaccine project. Objectives The aim of the present study is to evaluate the role of HCV core protein in inducing IFN-Gamma secretion and TCL activities as a vaccine in Balb/C mice. Material and Methods Our previous cloned plasmid (HCV Core gene into pETDuet-1) applied for protein expression in bacteria. The expressed and purified recombinant protein together with Freund’s adjuvant was injected to 15 Balb/c mice. The total IgG and IgG2a of immunized mice sera were evaluated after a week. Two weeks after booster injection, we studied the proliferation and IFNγ secretion of spleens, inguinal and popliteal lymph nodes lymphocytes by ELISA and ELISPOT. Results The FSFC (Frequency of spot forming cells) of secreting cells of immunized mice with HCV/Core protein and sera IgG2a were considerably higher than the control groups. Conclusions The core protein together with proper adjuvant can be a candidate vaccine against of HCV infection.

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The Role of Assisted Ventilation in Survival After Respiratory Failure in Children With AIDS

Cited by 2 publications

References 19 publications

Challenges in the provision of ICU services to HIV infected children in resource poor settings: a South African case study: Table 1

Challenges in the provision of ICU services to HIV infected children in resource poor settings: a South African case study: Table 1

The Evaluation of Hepatitis C Virus Core Antigen in Immunized Balb/C Mice

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