The Role of Aspirin in Non-Arteritic Anterior Ischaemic Optic Neuropathy

Hayreh, Sohan Singh

doi:10.3109/01658100903582811

Cited by 9 publications

(2 citation statements)

References 32 publications

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“…However, while platelets do play an important role in thrombo-occlusive disease, their role in NA-AION is less clear. According to Hayreh 31 , in the typical NA-AION, which is a hypotensive disorder, there is no scientific rationale for aspirin use in preventing recurrences of NA-AION, if not for a small number of cases due to true embolism, where it may be beneficial 31 .…”

Section: Discussionmentioning

confidence: 99%

Red Cell Distribution Width (RDW) and Complete Blood Cell Count-Derived Measures in Non-Arteritic Anterior Ischemic Optic Neuropathy

et al. 2021

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Purpose: To assess the role of complete blood cell count (CBC) dimensional indices and CBC-derived measures in non-arteritic anterior ischemic optic neuropathy (NA-AION). Methods: In this retrospective case-control survey, 37 newly diagnosed NA-AION patients and 37 sex- and age-matched cataract controls were enrolled in 2017-2018. On the same day of NA-AION diagnosis, a blood sample was collected and CBC was determined using an automatic blood counter. CBC dimensional indices, such as mean platelet volume (MPV) and red cell distribution width (RDW), and CBC-combined indices, including neutrophil/lymphocyte ratio (NLR), derived NLR [dNLR = neutrophils/(white blood cells - neutrophils)], and platelet/lymphocyte ratio (PLR), were evaluated. Erythrocyte sedimentation rate (ESR) was also measured. Results: Mean platelet count, median MPV, RDW, NLR, and dNLR were 221±48 x 10 9 /L, 8.2 fL (IQR=7.6-8.9), 13% (IQR=12-14.5), 2.50 (IQR=1.77-3.06), and 1.73 (IQR=1.31-2.07) in NA-AION patients and 248±56 x 10 9 /L, 7.60 fL (IQR=7.05-8.25), 12% (IQR=11.6-13), 1.95 (IQR=1.43-2.49) and 1.36 (IQR=1.07-1.69) in controls. NA-AION patients showed significantly lower platelet count (p=0.03) and significantly higher median values of MPV (p=0.01), RDW (p=0.015), NLR (p=0.03), and dNLR (p=0.01). Multivariate logistic regression models disclosed a significant correlation only between higher levels of RDW and NA-AION (p≤0.05). The attributable risk of the association between NA-AION and RDW was 33%. Conclusions: Results suggest that RDW may be somehow involved in the pathogenesis of NA-AION. However, high-quality cohort studies are warranted to confirm whether, or not, an altered RDW may be considered a potential biomarker of this vascular disorder affecting the optic nerve.

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Section: Discussionmentioning

confidence: 99%

Red Cell Distribution Width (RDW) and Complete Blood Cell Count-Derived Measures in Non-Arteritic Anterior Ischemic Optic Neuropathy

et al. 2021

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“…Also hypercoagulable states have been considered to play a role in the development of NAION but have been discussed controversially (15)(16)(17)(18)(19)(20)(21). Recent publications describe NAION as a multifactorial or multicausal disease; since cardiovascular risk factors have already been studied, we decided to focus on thrombophilic risk factors instead (1,5,8,17,(22)(23)(24)(25)(26). Large comprehensive studies evaluating risk factors of haemostasis, inflammation, and atherosclerosis are missing.…”

Section: Zusammenfassungmentioning

confidence: 99%

Associations between thrombophilic risk factors and determinants of atherosclerosis and inflammation in patients with non-arteritic anterior ischaemic optic neuropathy

Zotz¹,

Finger²,

Scharf³

et al. 2016

Hamostaseologie

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Vascular Diseases of the Optic Nerve: Internal Medicine Aspects

Paragh

2016

Neuro-Ophthalmology

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György Pfl ieglerBlood vessels supplying ocular structures originate from the internal carotid artery, so the blood supply of the eyes and the brain are closely connected. The various branches of the ophthalmic artery (central retinal artery, short and long posterior ciliary arteries, lacrimal artery, anterior ciliary artery) originating from the internal carotid artery and the corresponding veins are responsible for supplying the region indicated by their name. In rare cases, when the ophthalmic artery is absent, the medial meningeal artery performs the same task. The uvea is supplied by the ciliary artery, and the retina gets its blood supply from the branches of the central retinal artery. The posterior ciliary arteries (that supply the optic disc) and the central retinal artery (that supplies the medial two-thirds of the retina) are the fi rst arteries to branch off the ophthalmic artery that enters through the optic foramen. The central retinal artery divides into superior temporal, inferior temporal and nasal branches. The next vessels to branch off are the long posterior ciliary arteries that supply the peripheral parts of the choroidea, the ciliary body and the iris. The last branch is that of the anterior ciliary arteries. Venous drainage from the retina is carried out by the central retinal vein and its smaller branches that have the same name and course as the corresponding arteries. The vorticose veins drain the choroidea towards the inferior and superior ophthalmic vein and the cavernous sinus. The capillary network between the retinal arteries and veins serves to ensure overly effi cient oxygen and nutrient exchange. It is only the macula lutea (responsible for acute vision) and the fovea centralis that have no capillaries. Another special feature of these vessels is that retinal blood vessels have the same structure as cervical ones, and it is also true for uveal and extracranial vessels. These veins and arteries are located very close to each other, sometimes in the same adventitia sheath.Syndromes developing as a result of circulatory disorders of the eyes ( ocular ischemic syndromes ) are rather diffi cult to review, especially for those not specialized in ophthalmology. Therefore, fi rst we should interpret the terminology used in scientifi c literature (Table 43.1 ). However, in order to set up the differential diagnosis, we have to emphasize that the symptoms do not only mean loss of vision due to circulatory disorders of hematological or hemostaseological G. Pfl iegler , M.D., med. habil.

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The Role of Aspirin in Non-Arteritic Anterior Ischaemic Optic Neuropathy

Cited by 9 publications

References 32 publications

Red Cell Distribution Width (RDW) and Complete Blood Cell Count-Derived Measures in Non-Arteritic Anterior Ischemic Optic Neuropathy

Red Cell Distribution Width (RDW) and Complete Blood Cell Count-Derived Measures in Non-Arteritic Anterior Ischemic Optic Neuropathy

Associations between thrombophilic risk factors and determinants of atherosclerosis and inflammation in patients with non-arteritic anterior ischaemic optic neuropathy

Vascular Diseases of the Optic Nerve: Internal Medicine Aspects

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