The role of arterial stiffness in the onset of Takotsubo cardiomyopathy observed with noradrenaline administration and intracranial blood injection in rabbits

Takahashi, Mitsuru; Miyazaki, Chikao; Cao, Xin; Sato, Shuji; Shimizu, Kazuhiro; Chiba, Toshiro; Tsukuma, Hisayuki; Komatsu, Tetsuya; Aimoto, Megumi; Nagasawa, Yoshinori; Takahara, Akira; Shirai, Kohji

doi:10.1007/s00380-022-02223-8

Heart Vessels

2023

DOI: 10.1007/s00380-022-02223-8

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The role of arterial stiffness in the onset of Takotsubo cardiomyopathy observed with noradrenaline administration and intracranial blood injection in rabbits

Mitsuru Takahashi

Chikao Miyazaki²,

Xin Cao

et al.

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2024

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Histologic characterization of spontaneous catecholamine-induced cardiomyopathy in laboratory New Zealand White rabbits

Reed

2024

J VET Diagn Invest

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Catecholamine-induced cardiomyopathy (CCM) is an entity associated with increased levels of catecholamines causing subendocardial and papillary muscle cardiomyocyte degeneration and necrosis. In 2020, 49 autopsies from early rabbit deaths in a colony used for medical device biocompatibility studies were submitted for microscopic examination. Of the 49 rabbits, 26 had histologic changes consistent with CCM. No common stressor for CCM was determined in affected rabbits. Animals were generally male, were 12–16-wk-old, and were found dead or had bloating, lethargy, and/or diarrhea. Those observed with clinical signs were euthanized and autopsied per the organization’s standard operating procedures. Heart lesions consisted of various degrees of apical subendocardial myocardial degeneration and necrosis. Common non-cardiac lesions included pulmonary congestion and edema, hepatic congestion and centrilobular hepatocellular degeneration, and/or variable intestinal submucosal edema.

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Histologic characterization of spontaneous catecholamine-induced cardiomyopathy in laboratory New Zealand White rabbits

Reed

2024

J VET Diagn Invest

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The role of arterial stiffness in the onset of Takotsubo cardiomyopathy observed with noradrenaline administration and intracranial blood injection in rabbits

Cited by 1 publication

References 16 publications

Histologic characterization of spontaneous catecholamine-induced cardiomyopathy in laboratory New Zealand White rabbits

Histologic characterization of spontaneous catecholamine-induced cardiomyopathy in laboratory New Zealand White rabbits

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