The role of arrhythmias in the progression of heart failure

Ferrari, Gaetano M. De; Tavazzi, Luigi

doi:10.1016/s1388-9842(99)00004-5

Cited by 13 publications

(13 citation statements)

References 32 publications

(33 reference statements)

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“…Second, the presence of ambient arrhythmias was required for enrollment in the DEFINITE trial. Third, 24.5% of patients in the DEFINITE trial had atrial fibrillation, a condition associated with a worse prognosis, as mentioned in the preceding text (31). Conversely, Bloomfield et al (22), similarly to the present study, excluded patients with atrial fibrillation and patients with LVEF Ͼ40%.…”

Section: Study Limitationsmentioning

confidence: 47%

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Prognostic Value of T-Wave Alternans in Patients With Heart Failure Due to Nonischemic Cardiomyopathy

Salerno‐Uriarte

Ferrari

Klersy

et al. 2007

Journal of the American College of Cardiology

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115

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Section: Study Limitationsmentioning

confidence: 47%

“…However, the mechanisms of arrhythmias in patients with nonischemic heart failure (30,31) Vol. 50, No.…”

Section: Discussionmentioning

confidence: 99%

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Prognostic Value of T-Wave Alternans in Patients With Heart Failure Due to Nonischemic Cardiomyopathy

Salerno‐Uriarte

Ferrari

Klersy

et al. 2007

Journal of the American College of Cardiology

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115

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“…The same is true of atrial fibrillation (AF). Moreover, depending on the severity of HF, the two often occur together [1,2]. While AF is relatively uncommon in mild‐to‐moderate HF, it is a common concomitant disorder in severe disease.…”

Section: Introductionmentioning

confidence: 99%

Impact of atrial fibrillation on mortality in patients with chronic heart failure

Berg

Gelder

Veldhuisen

2002

European J of Heart Fail

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Chronic heart failure and atrial fibrillation often occur together. The aim of the study is to review the available literature on the impact of atrial fibrillation on mortality in patients with heart failure. Using MEDLINE six full papers were identified. In the studies with severe heart failure atrial fibrillation did not emerge as an independent predictor of mortality beyond standard clinical variables. In contrast, atrial fibrillation was associated with increased mortality in case of mild-to-moderate heart failure.

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“…From a pathophysiological point of view, it appears likely that atrial fibrillation may contribute to the progression of heart failure [23] and that an attempt to restore sinus rhythm may be particularly warranted in the population with dilated heart failure due to the preservation of atrial transport function, the limitation of atrial enlargement and the potential for lowering embolic risk. Atrial tachyarrhythmias may play a role in the acute decompensation of patients with heart failure, accounting for approximately 7% of the episodes of acute decompensation in a prospective evaluation [24].…”

Section: Treatment Of Atrial Fibrillation In Heart Failure Patientsmentioning

confidence: 99%

Atrial Fibrillation: Rhythm or Rate Control?

Landolina¹,

Ferrari²,

Cantù³

et al. 2003

Heart Drug

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Atrial fibrillation is the most common sustained cardiac arrhythmia. Its prevalence increases with age, reaching 5% among subjects over 65 years of age. Recently, evaluation of the best therapeutic approach to patients with atrial fibrillation has been the object of two multicenter clinical trials that have compared a strategy of rhythm control and one of rate control. The Atrial Fibrillation Follow-up Investigation of Rhythm Management trial enrolled a total of 4,060 patients with a mean age of 69.7 years. After a mean follow-up of 5 years, total mortality was 24% in the rhythm control group and 21% in the rate control group, leading to a hazard ratio of 1.15 (p = 0.08). Similar results were found in the smaller Rate Control versus Electrical Cardioversion for Persistent Atrial Fibrillation study. The two studies clearly indicate that rate control is not inferior to rhythm control in the general population of patients with atrial fibrillation and that the restoration of sinus rhythm should not be pursued aggressively. The data also suggest the opportunity for adequate anticoagulation among patients assigned to the rhythm control strategy. The characteristics of the patients enrolled as well as the analysis of subgroups suggest that the preference toward a rate control strategy may not apply to young patients who are moderately or highly symptomatic for atrial fibrillation, nor to patients with heart failure, in whom the arrhythmia may contribute to the progression of the disease. For these two classes of patients, rhythm control may still be an attractive option.

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The role of arrhythmias in the progression of heart failure

Cited by 13 publications

References 32 publications

Prognostic Value of T-Wave Alternans in Patients With Heart Failure Due to Nonischemic Cardiomyopathy

Prognostic Value of T-Wave Alternans in Patients With Heart Failure Due to Nonischemic Cardiomyopathy

Impact of atrial fibrillation on mortality in patients with chronic heart failure

Atrial Fibrillation: Rhythm or Rate Control?

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