The role of arginine-vasopressin for pineal melatonin synthesis in the rat: Involvement of vasopressinergic receptors

Stehle, Jörg H.; Reuss, Stefan; Riemann, Randolf; Seidel, André; Vollrath, Lutz

doi:10.1016/0304-3940(91)90175-s

Cited by 41 publications

(19 citation statements)

References 27 publications

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“…Similar effects have been observed upon intra-arterial AVP injections (Schröder et al 1988a), supporting the assumption that the active principle in these experiments is the secretion of AVP. In accordance with this concept are the findings in Brattleboro rats (bearing hereditary AVP deficiency) that electrical stimulation of the PVN is without effect (Reuss et al 1990b) and that the systemic application of AVP diminishes pineal melatonin synthesis (Stehle et al 1991). Similarly, the in vitro perifusion of Sprague-Dawley (SD) rat pineals with AVP at low doses decreases melatonin secretion but, at high concentrations, it potentiates the isoproterenol-induced increase of melatonin secretion (Simonneaux et al 1990).…”

Section: Intrahypothalamic Efferents Of the Scnmentioning

confidence: 74%

“…Comparable results, i.e. the augmentation of pineal melatonin synthesis in the presence of noradrenaline, have been obtained in vitro from SD rat pineals (Stehle et al 1991). In addition, the infusion of AVP into the PVN during the dark phase leads to slightly elevated plasma melatonin levels in rats (Kalsbeek et al 1993).…”

Section: Intrahypothalamic Efferents Of the Scnmentioning

confidence: 79%

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Components and connections of the circadian timing system in mammals

Reuss

1996

Cell and Tissue Research

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102

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The circadian timing system is a neural network consisting of the hypothalamic suprachiasmatic nucleus, aided by the retina, other hypothalamic nuclei, autonomic regions of the spinal cord, sympathetic ganglia and the pineal gland. Extensive studies conducted over the last two decades have unravelled the principal items of its functional neuroanatomy. The system is responsible for the generation of the circadian rhythm, its synchronization by environmental factors such as light, and its mediation with respect to morphological, physiological and biochemical parameters of mammals that exhibit distinct alterations throughout the 24-h cycle. This review characterizes the brain sites involved and the pathways responsible for the generation and maintenance of circadian rhythmicity.

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Section: Intrahypothalamic Efferents Of the Scnmentioning

confidence: 74%

Section: Intrahypothalamic Efferents Of the Scnmentioning

confidence: 79%

Components and connections of the circadian timing system in mammals

Reuss

1996

Cell and Tissue Research

Self Cite

102

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“…Although the melatonin rhythm appears to be normal in the VP-lacking Brattleboro rat (Reuss et al 1990;Schröder et al 1988b), a number of studies have reported modulatory effects of both VP and VIP on pineal activity. The experimental setup in these studies, however, does not allow for any definite conclusions about the site of action of these neurotransmitters (Yuwiler 1983;Schröder et al 1988aSchröder et al , 1989Stehle et al 1991). Localized microinfusions with VP or VIP in the PVN during the first 7 h of the dark period elicits a small stimulatory rather than the expected inhibitory effect on plasma melatonin levels (Kalsbeek et al 1993).…”

Section: The Hpg Axismentioning

confidence: 97%

Output pathways of the mammalian suprachiasmatic nucleus: coding circadian time by transmitter selection and specific targeting

2002

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Every day, we experience profound changes in our mental and physical condition as body and brain alternate between states of high activity during the waking day and rest during night-time sleep. The fundamental evolutionary adaptation to these profound daily changes in our physiological state is an endogenous 24-h clock. This biological clock enables us to prepare ourselves to these daily changes, instead of only being able to show a passive and delayed response. During the past decade, enormous progress has been made in determining possible molecular components of the biological clock. An important question remains, however, regarding how the rhythmic signal from the biological clock is spread throughout the body to control its physiology and behavior. Indeed, ultimately, the only raison d'etre for the biological clock is its output (Green 1998). In the present review, we propose that the main mechanism for the spreading time-of-day information throughout the body consists of different circadian waves of suprachiasmatic nucleus (SCN) transmitter release, directed to a restricted number of specific SCN target areas, and affecting both neuroendocrine mechanisms and the peripheral autonomic nervous system.

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“…VP potentiation of MEL synthesis occurs for low and moderate, but not high, ␤ 1 -AR stimulation. The VP effect occurs via potentiation of cAMP accumulation (Simonneaux et al, 1996a) and consequent AA-NAT activation (Stehle et al, 1991). The observation that VP potentiation of MEL synthesis is inhibited by a V 1a -R antagonist (Simonneaux et al, 1996a) suggested the presence of V 1a -R receptors in the rat pineal gland.…”

Section: Multiple Regulation Of Pineal Melatonin Synthesis In Mammalsmentioning

confidence: 99%

Generation of the Melatonin Endocrine Message in Mammals: A Review of the Complex Regulation of Melatonin Synthesis by Norepinephrine, Peptides, and Other Pineal Transmitters

2003

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The role of arginine-vasopressin for pineal melatonin synthesis in the rat: Involvement of vasopressinergic receptors

Cited by 41 publications

References 27 publications

Components and connections of the circadian timing system in mammals

Components and connections of the circadian timing system in mammals

Output pathways of the mammalian suprachiasmatic nucleus: coding circadian time by transmitter selection and specific targeting

Generation of the Melatonin Endocrine Message in Mammals: A Review of the Complex Regulation of Melatonin Synthesis by Norepinephrine, Peptides, and Other Pineal Transmitters

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