The role of apigenin in an experimental model of acute pancreatitis

Lampropoulos, Pavlos; Lambropoulou, María; Papalois, Αpostolos; Basios, Neofitos; Manousi, Maria; Simopoulos, Constantinos; Tsaroucha, Alexandra

doi:10.1016/j.jss.2012.11.053

Cited by 32 publications

(24 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…At present, all attention is focused on antioxidant and anti-inflammatory therapies. 2,3,4,6,18,20 Quercetin has been reported to exert multiple biological effects such as antioxidant, anti--inflammatory, and antihistaminic effects etc.…”

Section: ■ Discussionmentioning

confidence: 99%

“…14,[16][17][18][19] Recent studies have focused on antioxidant and anti-inflammatory properties of phenolic compounds. 2,4,6,20 Quercetin (3,5,7,3',4' pentahydroxyflavone) is a plant-derived phenolic compound belonging to a class of substances known as flavonoids. Flavonoids are widely found in vegetables, such as black and green tea, red wine, apple, onion, bean etc.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

The effect of quercetin on cerulein-induced acute pancreatitis

Kahraman¹,

Vurmaz²,

Koca³

et al. 2017

Medical Express

View full text Add to dashboard Cite

OBJECTIVE:The aim of this study was to evaluate the protective and therapeutic effects of quercetin on pancreatic injury in cerulein-induced acute pancreatitis. METHOD: Thirty-two rats were randomly divided into four groups, eight per group: (CT): untreated controls, (CER) treated with cerulein, 50 μg/kg body weight; (Q+CER) pre-treatment with quercetin, 100 mg/kg body weight, followed by cerulein, 50 μg/kg; (CER+Q) post-treatment, cerulein followed by quercetin, same doses. Cerulein was divided into four doses, given at 1-hour intervals by intraperitoneal injection. Quercetin was given either 1-hour before (in pre-treatment group) or 1-hour after (in post-treatment group) cerulein. Pancreatic malondialdehyde (MDA), carbonyl, myeloperoxidase (MPO), tumor necrosis factor-alpha (TNF-a), interleukin-6 (IL-6), reduced and oxidized glutathione (GSH and GSSG, respectively) were measured. Histology of the pancreas was studied. RESULTS: (1) MDA, carbonyl, MPO, TNF-a and IL-6 levels were significantly higher in CER vs CT rats. (2) MDA, carbonyl, MPO and TNF-α decreased significantly in pre-treated rats vs. CER. (3) MDA, MPO, TNF-α, IL-6 were significantly lower in post-treated rats vs. CER. (4) The reduced vs. oxidized glutathione ratio (GSH/GSSG) of was significantly lower CER vs. CT rats. (5) Pre-and post-treatment with quercetin significantly increased this ratio. (6) Pancreatic histology showed that quercetin had no significant effect on the histological image of the pancreas CONCLUSION: These results suggest that quercetin can attenuate the severity of cerulein-induced acute pancreatitis by acting as an antioxidant and anti-inflammatory agent and combating oxidative stress. Further studies are needed to clearly explain its utility on acute pancreatitis.

show abstract

Section: ■ Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

The effect of quercetin on cerulein-induced acute pancreatitis

Kahraman¹,

Vurmaz²,

Koca³

et al. 2017

Medical Express

View full text Add to dashboard Cite

show abstract

“…The role of apigenin in an experimental model of acute pancreatitis has been tested and results indicate oral apigenin administration in rats, following experimentallyinduced pancreatitis, seems to protect the pancreatic tissue. Thus, apigenin administration to humans could potentially ameliorate damage to the pancreas [71]. Apigenin is also effective in experimental chronic pancreatitis where it inhibits the activity of pancreatic stellate cells [72].…”

Section: Apigeninmentioning

confidence: 99%

Chronic Pancreatitis Associated Acute Respiratory Failure

Anil¹

2017

MOJI

View full text Add to dashboard Cite

“…The role of apigenin in an experimental model of acute pancreatitis has been tested and results indicate oral apigenin administration in rats, following experimentally-induced pancreatitis, seems to protect the pancreatic tissue. Thus, apigenin administration to humans could potentially ameliorate damage to the pancreas [71]. Apigenin is also effective in experimental chronic pancreatitis where it inhibits the activity of pancreatic stellate cells [72].…”

Section: Introductionmentioning

confidence: 99%

Chronic Pancreatitis Associated Acute Respiratory Failure

Manohar

Verma

Venkateshaiah

et al. 2017

MOJI

View full text Add to dashboard Cite

Pancreatitis is a condition characterized by parenchymal inflammation of the pancreas, which is often associated with lung injury due to low level of oxygen and the condition is termed as acute pancreatitis-associated lung injury (APALI). Clinical reports indicated that ~ 20% to 50% of patients from low oxygen levels in blood with acute respiratory distress syndrome (ARDS). ARDS is a severe form of acute lung injury (ALI), a pulmonary disease with impaired airflow making patients difficult to breathe. ALI is frequently observed in patients with severe acute pancreatitis. Approximately one third of severe pancreatitis patients develop acute lung injury and acute respiratory distress syndrome that account for 60% of all deaths within the first week. The major causes of ALI and ARDS are sepsis, trauma, aspiration, multiple blood transfusion, and most importantly acute pancreatitis. The molecular mechanisms of ALI and ARDS are still not well explored, but available reports indicate the involvement of several pro-inflammatory mediators including cytokines (TNF-α, IL-1β, IL-6) and chemokines [like interleukin-8 (IL-8) and macrophage inhibitory factor (MIF)], as well as macrophage polarization regulating the migration and pulmonary infiltration of neutrophils into the pulmonary interstitial tissue, causing injury to the pulmonary parenchyma. Acute lung injury and acute respiratory distress syndrome in acute pancreatitis remains an unsolved issue and needs more research and resources to develop effective treatments and therapies. However, recent efforts have tested several molecules in an experimental model and showed promising results as a treatment option. The current review summarized the mechanism that is operational in pancreatitis-associated acute respiratory failure and respiratory distress syndrome in patients and current treatment options.

show abstract

The role of apigenin in an experimental model of acute pancreatitis

Cited by 32 publications

References 43 publications

The effect of quercetin on cerulein-induced acute pancreatitis

The effect of quercetin on cerulein-induced acute pancreatitis

Chronic Pancreatitis Associated Acute Respiratory Failure

Chronic Pancreatitis Associated Acute Respiratory Failure

Contact Info

Product

Resources

About