The Role of Ap-1 Transcription Factor Activation in the Changes of Production and Utilization of Nitric Oxide in the Gastric Mucosa of Rats Under Conditions of Chronic Fluoride Intoxication
Abstract:Millions of people are affected by excessive fluoride intake. The effect of fluorides on the activation or inhibition of redox-sensitive transcription factors remains poorly understood. The aim of this research is to examine the effect of activation of the transcription factor AP-1 on changes in the activity of inducible NO synthase and constitutive isoforms of NO synthase, concentrations of peroxynitrites of alkali and alkaline earth metals, concentrations of nitrites and nitrosothiols in the gastric mucosa o… Show more
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