The role of antioxidant supplementation in occupational exposure to waste anaesthetic gases

Şardaş, Semra; İzdeş, Seval; Özçağlı, Eren; Kanbak, Orhan; Kadıoğlu, Ela

doi:10.1007/s00420-006-0115-6

Cited by 39 publications

(26 citation statements)

References 21 publications

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“…Even after a12-week supplementation with ascorbic acid (500 mg/day) and tocopherol (300 mg/day), the exposed group, although with a reduction of DNA damage, still showed more damage than the controls 36 . Nurses have been reported to have increased oxidative DNA damage, lipoperoxidation and decreased GPX activity without alteration of alpha-tocopherol levels, when exposed from five to 27 years to high levels of N 2 O…”

Section: Discussionmentioning

confidence: 85%

DNA damage and antioxidant status in medical residents occupationally exposed to waste anesthetic gases

et al. 2014

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PURPOSE:To investigate the effects of occupational exposure to waste anesthetic gases on genetic material and antioxidant status in professionals during their medical residency. METHODS:The study group consisted of 15 medical residents from Anesthesiology and Surgery areas, of both genders, mainly exposed to isoflurane and to a lesser degree to sevoflurane and nitrous oxide; the control group consisted of 15 young adults not exposed to anesthetics. Blood samples were drawn from professionals during medical residency (eight, 16 and 22 months of exposure to waste anesthetic gases). DNA damage was evaluated by comet assay, and antioxidant defense was assessed by total thiols and the enzymes glutathione peroxidase (GPX), superoxide dismutase (SOD) and catalase (CAT). RESULTS:When comparing the two groups, DNA damage was significantly increased at all time points evaluated in the exposed group; plasma thiols increased at 22 months of exposure and GPX was higher at 16 and 22 months of exposure.CONCLUSION: Young professionals exposed to waste anesthetic gases in operating rooms without adequate scavenging system have increased DNA damage and changes in redox status during medical residency. There is a need to minimize exposure to inhalation anesthetics and to provide better work conditions.

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Section: Discussionmentioning

confidence: 85%

DNA damage and antioxidant status in medical residents occupationally exposed to waste anesthetic gases

et al. 2014

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“…A number of known antioxidants contribute to the defense against reactive oxygen species (ROS) in the organism. Small molecule dietary antioxidants (vitamin A [31], C [32–35], E [32, 33, 35–37], β-carotene [32, 34]), and some others [30, 31, 38, 39] have shown a significant protection against oxidative stress measured by different methods. When investigating the involvement of oxidative stress in cancer development, the important question is: what are the most appropriate biomarkers of oxidative stress and what is the best way to measure them?…”

Section: Discussionmentioning

confidence: 99%

The Effect of Selenium Supplementation in the Prevention of DNA Damage in White Blood Cells of Hemodialyzed Patients: A Pilot Study

Zachara

Gromadzińska

Palus

et al. 2010

Biol Trace Elem Res

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Patients with chronic kidney disease (CKD) have an increased incidence of cancer. It is well known that long periods of hemodialysis (HD) treatment are linked to DNA damage due to oxidative stress. In this study, we examined the effect of selenium (Se) supplementation to CKD patients on HD on the prevention of oxidative DNA damage in white blood cells. Blood samples were drawn from 42 CKD patients on HD (at the beginning of the study and after 1 and 3 months) and from 30 healthy controls. Twenty-two patients were supplemented with 200 μg Se (as Se-rich yeast) per day and 20 with placebo (baker's yeast) for 3 months. Se concentration in plasma and DNA damage in white blood cells expressed as the tail moment, including single-strand breaks (SSB) and oxidative bases lesion in DNA, using formamidopyrimidine glycosylase (FPG), were measured. Se concentration in patients was significantly lower than in healthy subjects (P < 0.0001) and increased significantly after 3 months of Se supplementation (P < 0.0001). Tail moment (SSB) in patients before the study was three times higher than in healthy subjects (P < 0.01). After 3 months of Se supplementation, it decreased significantly (P < 0.01) and was about 16% lower than in healthy subjects. The oxidative bases lesion in DNA (tail moment, FPG) of HD patients at the beginning of the study was significantly higher (P < 0.01) compared with controls, and 3 months after Se supplementation it was 2.6 times lower than in controls (P < 0.01). No changes in tail moment was observed in the placebo group. In conclusion, our study shows that in CKD patients on HD, DNA damage in white blood cells is higher than in healthy controls, and Se supplementation prevents the damage of DNA.

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“…Antioxidant supplements increase the resistance of lymphocytes to oxidative damage [Sardas et al, 2006]. Vitamin C has been reported to reduce the mutagenic effects of cytotoxic agents .…”

Section: Discussionmentioning

confidence: 99%

Effects of low dose radiation and vitamin C treatment on chloroquine‐induced genotoxicity in mice

Roy

Mazumdar

Giri

2008

Environ and Mol Mutagen

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Chloroquine (CHQ) is a commonly used antimalarial agent. We evaluated the genotoxic potential of CHQ using chromosome aberration (CA), micronucleus (MN), and sperm head abnormality (SA) assays in vivo in Swiss albino mice. The interaction between a low dose of radiation and CHQ, as well as the effect of vitamin C on CHQ-induced genotoxicity, was also evaluated. It was observed that CHQ induced CA, as well as MN, in the bone marrow cells under certain treatment conditions. Further, CHQ induced significant increase in the frequency of SA both at 24 hr and 21 days of the treatment. In the present study vitamin C pretreatment apparently reduced the frequency of CA, MN, and SA induced by CHQ. In the combination studies with radiation and CHQ, we found that exposure to low doses of radiation (0.5 Gy) either prior to or following CHQ treatment, in the dose ranges tested, has little or no synergistic effect in the mutagenic evaluations in somatic cells. However, radiation exposure along with CHQ treatment resulted in significant increase in the frequency of SA as compared to the groups receiving CHQ alone at 21 days of the treatment. In summary, CHQ has the potential to induce genotoxicity in mammalian cells. Further, germ cells may be relatively more sensitive as compared to the somatic cells.

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The role of antioxidant supplementation in occupational exposure to waste anaesthetic gases

Abstract: The results of our study indicate that occupational exposure to anaesthetic gases induces oxidative DNA damage. Supplementation of the diet for 12 weeks with vitamin C and vitamin E resulted in a significant decrease in the DNA damage.

Cited by 39 publications

References 21 publications

DNA damage and antioxidant status in medical residents occupationally exposed to waste anesthetic gases

DNA damage and antioxidant status in medical residents occupationally exposed to waste anesthetic gases

The Effect of Selenium Supplementation in the Prevention of DNA Damage in White Blood Cells of Hemodialyzed Patients: A Pilot Study

Effects of low dose radiation and vitamin C treatment on chloroquine‐induced genotoxicity in mice

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