The role of anticomplement therapy in the management of the kidney allograft
Mehmet Kanbay,
Sidar Copur,
Zeynep Y. Yilmaz
et al.
Abstract:As the number of patients living with kidney failure grows, the need also grows for kidney transplantation, the gold standard kidney replacement therapy that provides a survival advantage. This may result in an increased rate of transplantation from HLA‐mismatched donors that increases the rate of antibody‐mediated rejection (AMR), which already is the leading cause of allograft failure. Plasmapheresis, intravenous immunoglobulin therapy, anti‐CD20 therapies (i.e., rituximab), bortezomib and splenectomy have b… Show more
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