The role of antibiotics in chronic bacterial prostatitis

Pathogenic Consequences in Semen Quality of an Autoimmune Response against the Prostate Gland: From Animal Models to Human Disease

“…One important reason for this enthusiasm is the recognition that chronic prostatitis syndromes represent an important worldwide health care problem (2). Chronic bacterial prostatitis is characterized by uropathogenic infections of the prostate gland that respond well to antimicrobial treatment (3). In contrast, chronic nonbacterial prostatitis (CNBP) 3 (now classified as National Institutes of Health category III), which accounts for 90 -95% of prostatitis cases, is of unknown etiology and is characterized by the presence of a mixture of pain, urinary, and ejaculatory symptoms with no uniformly effective therapy (4 -6).…”

“…Chronic bacterial prostatitis is characterized by uropathogenic infections of the prostate gland that respond well to antimicrobial treatment (3). In contrast, chronic nonbacterial prostatitis (CNBP) 3 (now classified as National Institutes of Health category III), which accounts for 90 -95% of prostatitis cases, is of unknown etiology and is characterized by the presence of a mixture of pain, urinary, and ejaculatory symptoms with no uniformly effective therapy (4 -6). A rationale treatment is urgently required, because until now the goal therapy for these patients has not had good results, and it has focused on amelioration of symptoms rather than on a cure (7).…”

Penetration of doripenem into prostatic tissue following intravenous administration in prostatectomy patients

“…Nevertheless, the prostatic penetration of doripenem is considered to be much lower than that of quinolones. This may be due to the lower dissociation constant (pKa 1 = 2.8; pKa 2 = 7.9) and poorer lipid solubility (octanol/water partition coefficient = 0.002) of doripenem [2] compared with those of quinolones [12,13].…”

Prulifloxacin: a review focusing on its use beyond respiratory and urinary tract infections

“…Given that the prostate tissue is an anatomic department not easily penetrated, a favourable pharmacokinetic profile of an antibiotic is of great importance [35].…”