The Role of Anti-Phosphatidylserine/Prothrombin Antibodies in Thrombotic Manifestations of Systemic Lupus Erythematosus Patients

Tselios, Konstantinos; Sarantopoulos, Alexandros; Gkougkourellas, Ioannis; Boura, Panagiota

doi:10.3389/fneur.2013.00066

Cited by 7 publications

(10 citation statements)

References 3 publications

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“…21,32 Some studies support the association of aPS/PT with arterial thrombosis, mainly in the setting of cerebrovascular events. 33 Others reports showed the correlation between aPS/PT and venous thrombosis. 27,31 In our study, in both cohorts arterial and venous thromboses were associated with IgG aPS/PT.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of phosphatidylserine-dependent antiprothrombin antibody testing for the diagnosis of antiphospholipid syndrome: results of an international multicentre study

Amengual

Forastiero

Sugiura‐Ogasawara

et al. 2016

Lupus

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Objective: A task force of scientists at the International Congress on Antiphospholipid Antibodies recognized that phosphatidylserine-dependent antiprothrombin antibodies (aPS/ PT) might contribute to a better identification of antiphospholipid syndrome (APS). Accordingly, initial and replication retrospective, cross-sectional multicentre studies were conducted to ascertain the value of aPS/PT for APS diagnosis. Methods: In the initial study (eight centres, seven countries), clinical/laboratory data were retrospectively collected. Serum/plasma samples were tested for IgG aPS/PT at Inova Diagnostics (Inova) using two ELISA kits. A replication study (five centres, five countries) was carried out afterwards. Results: In the initial study (n ¼ 247), a moderate agreement between the IgG aPS/PT Inova and MBL ELISA kits was observed (k ¼ 0.598). IgG aPS/PT were more prevalent in APS patients (51%) than in those without (9%), OR 10.8, 95% CI (4.0-29.3), p < 0.0001. Sensitivity, specificity, positive (LRþ) and negative (LR-) likelihood ratio of IgG aPS/PT for APS diagnosis were 51%, 91%, 5.9 and 0.5, respectively. In the replication study (n ¼ 214), a moderate/substantial agreement between the IgG aPS/PT results obtained with both ELISA kits was observed (k ¼ 0.630). IgG aPS/PT were more prevalent in APS patients (47%) than in those without (12%), OR 6.4, 95% CI (2.6-16), p < 0.0001. Sensitivity, specificity, LR þ and LR-for APS diagnosis were 47%, 88%, 3.9 and 0.6, respectively. Conclusions: IgG aPS/PT detection is an easily performed laboratory parameter that might contribute to a better and more complete identification of patients with APS. Lupus (2016) 0, 1-11.

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Section: Discussionmentioning

confidence: 99%

Evaluation of phosphatidylserine-dependent antiprothrombin antibody testing for the diagnosis of antiphospholipid syndrome: results of an international multicentre study

Amengual

Forastiero

Sugiura‐Ogasawara

et al. 2016

Lupus

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“…Many subsequent reports have confirmed the association between aPS/PT and clinical manifestations of APS. 2,9,11,12 Recent data from Zigon et al 13 reported that aPS/PT was the strongest independent risk factor for the presence of antiphospholipid antibodies (aPL)-related obstetric complications in a cohort of 156 patients with systemic autoimmune diseases. Sanfelippo et al 14 tested aPS/PT in a large cohort of 728 patients suspected of having APS, in the absence of anticardiolipin antibodies (aCL) or anti-b2 glycoprotein I (anti-b2GPI).…”

Section: Clinical Utility Of Aps/pt In the Diagnosis Of Apsmentioning

confidence: 99%

“…Many subsequent reports have confirmed the association between aPS/PT and clinical manifestations of APS. 2,9,11,12…”

Section: Clinical Utility Of Aps/pt In the Diagnosis Of Apsmentioning

confidence: 99%

Antibodies to phosphatidylserine/prothrombin complex and the antiphospholipid syndrome

Sciascia

Bertolaccini

2014

Lupus

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Antibodies to prothrombin can be detected by ELISA using prothrombin coated onto irradiated plates (aPT) or the phosphatidylserine/prothrombin complex as antigen (aPS/PT) and they have been both related with the clinical manifestation of APS. Current evidence supports the concept that they belong to distinct populations of autoantibodies. Nevertheless, they can both be detected simultaneously in one patient.This mini-review will focus on data available on aPS/PT antibodies and their clinical utility in the diagnosis of APS.

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“…Several studies that followed confirmed the association between aPS/PT and the clinical manifestations of APS [32,33]. A large study in a cohort of 728 patients suspected of having APS, in the absence of aCL or anti-β2GPI showed that 41 of them (5.6%) had elevated levels of aPS/PT with thrombotic events occurring in 50% of these cases [34].…”

Section: Prothrombin/phosphatidylserine Complexmentioning

confidence: 95%

Can we withdraw anticoagulation in patients with antiphospholipid syndrome after seroconvertion?

Sciascia

Coloma

Radin

et al. 2017

Autoimmunity Reviews

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The Role of Anti-Phosphatidylserine/Prothrombin Antibodies in Thrombotic Manifestations of Systemic Lupus Erythematosus Patients

Cited by 7 publications

References 3 publications

Evaluation of phosphatidylserine-dependent antiprothrombin antibody testing for the diagnosis of antiphospholipid syndrome: results of an international multicentre study

Evaluation of phosphatidylserine-dependent antiprothrombin antibody testing for the diagnosis of antiphospholipid syndrome: results of an international multicentre study

Antibodies to phosphatidylserine/prothrombin complex and the antiphospholipid syndrome

Can we withdraw anticoagulation in patients with antiphospholipid syndrome after seroconvertion?

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