The role of anthropometric indices in the prediction of non-alcoholic fatty liver disease in the PERSIAN Guilan Cohort study (PGCS)

Mansour-Ghanaei, Roya; Mansour-Ghanaei, Fariborz; Naghipour, Mohammadreza; Joukar, Farahnaz; Atrkarroushan, Zahra; Tabatabaii, Mohammadjavad; Ghorani, Najmeh

doi:10.25122/jml-2018-0031

“…Findings of our study were also in agreement with another study on 164 cases with NAFLD and 164 controls without NAFLD, which indicated that patients with NAFLD were significantly more likely to be overweight, have abdominal obesity, and a significantly higher body fat content (39). In a recent cohort study conducted on 960 people in north of Iran, a significant positive relationship was reported between anthropometric indices (BMI, WC, WHR, and WHtR) and NAFLD (35). Fung et al (40) demonstrated that relative risk of NAFLD in subjects with high WC was 2.99.…”

Section: Discussionsupporting

confidence: 92%

Food insecurity and lipid profile abnormalities are associated with an increased risk of non- alcoholic fatty liver disease (NAFLD): a case-control study in northwest of Iran

Tutunchi

¹

,

Saghafi-Asl

²

,

Hosseinzadeh‐Attar

³

et al. 2020

Preprint

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Background Non-alcoholic fatty liver disease (NAFLD) is an important public health problem and a significant cause of morbidity and mortality. Little is known about the relation between food insecurity and NAFLD. This study aimed to assess the relationship between food insecurity, risk factors associated with food insecurity, and NAFLD prevalence in a sample of Iranian adults.Methods In this age-matched and gender-matched case–control study, 210 subjects were recruited. NAFLD diagnosis was performed by a single expert radiologist using ultrasonography. The demographic and socioeconomic characteristics, anthropometric indices, body composition, along with food insecurity and depression status were assessed. Blood samples were collected to determine the lipid profile parameters. Chi-square, independent samples t-test, and uni-and multi-variate logistic regression tests were used. Data were analysed using SPSS V.23.0.Results The prevalence of food insecurity was 56.8% and 26.1% in cases and controls ( P<0.001 ), respectively. According to final analysis model, food insecurity, depression, number of children ≥ 4, overweight, and obesity were identified as significant independent risk factors for NAFLD. The chance of NAFLD in the food insecure, depressed, overweight, and obese subjects was 2.2 (95%CI: 1.12-3.43), 1.9 (95%CI: 1.02-3.62), 2.6 (95%CI: 1.81-3.92), and 2.9 (95%CI: 2.02- 5.34) times higher, respectively. Additionally, a higher waist circumference (men, OR = 2.9, P < 0.001 ; women, OR= 2.6, P< 0.001 ), an elevated waist-to-hip ratio (men, OR=2.3, P<0.001 ; women, OR=2.7, P<0.001 ), an increased waist-to-height ratio (OR=2.9, P<0.001 ), and a higher body fat percentage (men, OR=3.0, P<0.001 ; women, OR=3.3, P<0.001 ) were independently associated with an increased risk of NAFLD. The odds of NAFLD increased by increment in serum triglyceride (TG) levels (OR=2.6, P<0.001 ) and decreased by increase in serum high-density lipoprotein cholesterol (HDL-C) (OR=0.34, P<0.001 ). Compared to controls, NAFLD patients were more likely to have higher TG/HDL-C ratio (OR =3.3, P<0.001 ).Conclusions The prevalence of food insecurity in patients with NAFLD was significantly higher compared to controls. Food insecurity was associated with an increased risk of NAFLD, even after adjusting for potential confounding factors. Additionally, NAFLD was significantly related to some indicators of dyslipidemia.

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“…In line with our results, study performed by Cuenza et al [22] and Kim et al [17] showed that there was statistically significant increase in mean BMI with increasing severity of NAFLD. Similarly, in the PERSIAN Guilan Cohort study (PGCS) located in the north of Iran, a significant positive relationship between BMI and risk of NAFLD was reported [11].…”

Section: Discussionmentioning

confidence: 87%

“…Today, NAFLD is considered as a main chronic liver disease in Asia [10]. A number of studies found that higher body mass index (BMI) was associated with an increased risk of NAFLD [3,[11][12][13]. Moreover, abnormal lipid metabolism or dyslipidemia is one of the common risk factors for NAFLD and is related to cardiovascular mortality, which is the most common cause of death in these patients [14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

The relationship between severity of liver steatosis and metabolic parameters in a sample of Iranian adults

Tutunchi

¹

,

Saghafi-Asl

²

,

Asghari‐Jafarabadi

³

et al. 2020

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Objectives: This study aimed to examine the relationship between severity of liver steatosis and metabolic parameters in a sample of Iranian adults. In this cross-sectional study, a total of 95 subjects aged > 20 years newly diagnosed with NAFLD were recruited. NAFLD was diagnosed using ultrasonography by a single expert radiologist in a fasting state. Results: The mean age of the patients was 49.27 (SD 9.7) years, with 53.68% males and 46.32% females. Most patients had grade I NAFLD (72.63%), 25.26% were grade II, and 2.11% were grade III on ultrasonography. With increasing severity of liver steatosis, there were statistically significant increases in mean body mass index (P = 0.001), serum triglycerides (P = 0.026), alanine aminotransferase (P < 0.001), aspartate aminotransferase (P < 0.001), and fasting blood sugar (P = 0.041), and there was a statistically significant decrease in mean serum high-density lipoprotein cholesterol (P = 0.011). However, no association was found between severity of liver steatosis and serum total cholesterol (P = 0.271), low-density lipoprotein cholesterol (P = 0.341), and alkaline phosphatase (P = 0.234). In conclusion, the severity of ultrasonographic liver steatosis was significantly associated with abnormal metabolic parameters.

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“…Moreover, Fan et al (15) demonstrated that higher BMI (overweight/obesity) was an independent, dose-dependent risk factor for fatty liver. NAFLD prevalence is associated not only with higher BMI, but also is strongly related to central fat deposition (35). WC, WHR and WHtR have been considered as alternative indices for abdominal (visceral) obesity in previous studies (35,36).…”

Section: Discussionmentioning

confidence: 99%

“…NAFLD prevalence is associated not only with higher BMI, but also is strongly related to central fat deposition (35). WC, WHR and WHtR have been considered as alternative indices for abdominal (visceral) obesity in previous studies (35,36). Abdominal obesity is closely associated with development of metabolic diseases and adverse health outcomes.…”

Section: Discussionmentioning

confidence: 99%

Food Insecurity and Lipid Profile Abnormalities Are Associated with an Increased Risk of Nonalcoholic Fatty Liver Disease (NAFLD): A Case–Control Study

Tutunchi

¹

,

Saghafi-Asl

²

,

Ebrahimi-Mameghani

³

et al. 2021

Ecology of Food and Nutrition

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Background Non-alcoholic fatty liver disease (NAFLD) is an important public health problem and a significant cause of morbidity and mortality. Little is known about the relation between food insecurity and NAFLD. This study aimed to assess the relationship between food insecurity, risk factors associated with food insecurity, and NAFLD prevalence in a sample of Iranian adults. Methods In this age-matched and gender-matched case-control study, 210 subjects were recruited. NAFLD diagnosis was performed by a single expert radiologist using ultrasonography. The demographic and socioeconomic characteristics, anthropometric indices, body composition, along with food insecurity and depression status were assessed. Blood samples were collected to determine the lipid profile parameters. Chi-square, independent samples t-test, and uni-and multi-variate logistic regression tests were used. Data were analysed using SPSS V.23.0. Results The prevalence of food insecurity was 56.8% and 26.1% in cases and controls (P<0.001), respectively. According to final analysis model, food insecurity, depression, number of children≥4, overweight, and obesity were identified as significant independent risk factors for NAFLD. The chance of NAFLD in the food insecure,

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The role of anthropometric indices in the prediction of non-alcoholic fatty liver disease in the PERSIAN Guilan Cohort study (PGCS)

Cited by 21 publications

References 44 publications

Food insecurity and lipid profile abnormalities are associated with an increased risk of non- alcoholic fatty liver disease (NAFLD): a case-control study in northwest of Iran

Food insecurity and lipid profile abnormalities are associated with an increased risk of non- alcoholic fatty liver disease (NAFLD): a case-control study in northwest of Iran

The relationship between severity of liver steatosis and metabolic parameters in a sample of Iranian adults

Food Insecurity and Lipid Profile Abnormalities Are Associated with an Increased Risk of Nonalcoholic Fatty Liver Disease (NAFLD): A Case–Control Study

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