The role of annexin A1 in Candida albicans and Candida auris infections in murine neutrophils

Sanches, José Marcos; Rossato, Luana; Lice, Izabella; Fernandes, Anna Maria Alves de Piloto; Duarte, Gustavo Henrique Bueno; Silva, Alex; Porcari, Andréia M.; Carvalho, Patrícia de Oliveira; Gil, Cristiane Damas

doi:10.1016/j.micpath.2020.104689

Cited by 6 publications

(4 citation statements)

References 62 publications

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Section: Discussionmentioning

confidence: 99%

“…First, ANXA1 has the potential to down-regulate the immune responses initiated by bats arousing from torpor, which can lead to immunopathology if left unchecked. ANXA1 appears to regulate the neutrophil response under fungal infection conditions, altering lipid membrane organization and metabolism (Sanches et al 2021). ANXA1 has also been found to participate in adaptive immunity against chronic infectious disease (Vanessa et al 2015), by directing the immune response towards a Th1/Th17 response, a response that is associated not only with clearing fungal infection in normothermic mammals, but also the mortality evidenced in susceptible Nearctic populations of M. lucifugus infected by P. destructans (Lilley et al 2017).…”

Section: Discussionmentioning

confidence: 99%

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Signals of positive selection in Palearctic bat species coexisting with a fungal pathogen

Twort,

Laine,

Field

et al. 2023

Preprint

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Traits that directly influence the survival of an organism are suspect to positive selection. Disease can act as a driving force in shaping the genetic makeup across populations, even species, if the impacts are influencing a particularly sensitive part of their life cycles. White-nose syndrome is a fungal disease that affects bats during hibernation. The mycosis has caused massive population declines of susceptible species in North America, whereas in Eurasia, where the fungal pathogen has coevolved with its hosts for an extended period of time, bats appear to tolerate infection. Here, we adopted both whole-genome sequencing approaches and a literature search to compile a set of 300 genes from which to investigate for signals of positive selection in genomes of 11 Eurasian bats at the codon-level. Our results indicate significant positive selection in 38 genes, many of which have a marked role in responses to infection. Our findings suggest the fungal disease known as white-nose syndrome may have applied a significant selective pressure on hibernatory Eurasian Myotis-bats in the past, which can partially explain their survival in the presence of the pathogen.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Signals of positive selection in Palearctic bat species coexisting with a fungal pathogen

Twort,

Laine,

Field

et al. 2023

Preprint

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“…Furthermore, CDKN2AIP controls the activity and stability of the ribonuclease XRN2, which is associated with the NF-κΒ-repressing factor (Alexandrova et al 2020). The anti-inflammatory protein ANXA1 is mainly found in macrophages and neutrophils and is associated with inflammatory processes, immune infiltrates in cancer cells (Liang and Li 2021) and immune response during fungal infections (Sanches et al 2021). Given the anti-inflammatory role of ANXA1, it is surprising that the downregulation of the ANXA1 worm homologs nex-1 and nex-2 led to increased survival during pathogenic stress, which suggests distinct roles for ANXA1 and NEX-1/ NEX-2.…”

Section: Discussionmentioning

confidence: 99%

Identification of healthspan-promoting genes in Caenorhabditis elegans based on a human GWAS study

et al. 2022

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To find drivers of healthy ageing, a genome-wide association study (GWAS) was performed in healthy and unhealthy older individuals. Healthy individuals were defined as free from cardiovascular disease, stroke, heart failure, major adverse cardiovascular event, diabetes, dementia, cancer, chronic obstructive pulmonary disease (COPD), asthma, rheumatism, Crohn’s disease, malabsorption or kidney disease. Six single nucleotide polymorphisms (SNPs) with unknown function associated with ten human genes were identified as candidate healthspan markers. Thirteen homologous or closely related genes were selected in the model organism C. elegans for evaluating healthspan after targeted RNAi-mediated knockdown using pathogen resistance, muscle integrity, chemotaxis index and the activity of known longevity and stress response pathways as healthspan reporters. In addition, lifespan was monitored in the RNAi-treated nematodes. RNAi knockdown of yap-1, wwp-1, paxt-1 and several acdh genes resulted in heterogeneous phenotypes regarding muscle integrity, pathogen resistance, chemotactic behaviour, and lifespan. Based on these observations, we hypothesize that their human homologues WWC2, CDKN2AIP and ACADS may play a role in health maintenance in the elderly.

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“…In mycotic infections with Candida albicans or Candida auris, the activation of MAPK pathways and proinflammatory signaling has been recognized, paralleled by the fungal evasion of the innate immune response [190]. A contribution to this evasion is probably provided by the COX-2/PGE2 axis and subsequent signaling via IL-33 that negatively regulates immune responsiveness, as shown in mouse models of fungal exposure with Aspergillus fumigatus [191] or Alternaria alternata [192].…”

Section: Cox Pathways In Injured Lung Endotheliummentioning

confidence: 99%

Significance of Pulmonary Endothelial Injury and the Role of Cyclooxygenase-2 and Prostanoid Signaling

et al. 2023

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The endothelium plays a key role in the dynamic balance of hemodynamic, humoral and inflammatory processes in the human body. Its central importance and the resulting therapeutic concepts are the subject of ongoing research efforts and form the basis for the treatment of numerous diseases. The pulmonary endothelium is an essential component for the gas exchange in humans. Pulmonary endothelial dysfunction has serious consequences for the oxygenation and the gas exchange in humans with the potential of consecutive multiple organ failure. Therefore, in this review, the dysfunction of the pulmonary endothel due to viral, bacterial, and fungal infections, ventilator-related injury, and aspiration is presented in a medical context. Selected aspects of the interaction of endothelial cells with primarily alveolar macrophages are reviewed in more detail. Elucidation of underlying causes and mechanisms of damage and repair may lead to new therapeutic approaches. Specific emphasis is placed on the processes leading to the induction of cyclooxygenase-2 and downstream prostanoid-based signaling pathways associated with this enzyme.

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The role of annexin A1 in Candida albicans and Candida auris infections in murine neutrophils

Cited by 6 publications

References 62 publications

Signals of positive selection in Palearctic bat species coexisting with a fungal pathogen

Signals of positive selection in Palearctic bat species coexisting with a fungal pathogen

Identification of healthspan-promoting genes in Caenorhabditis elegans based on a human GWAS study

Significance of Pulmonary Endothelial Injury and the Role of Cyclooxygenase-2 and Prostanoid Signaling

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