The Role of Angiopoietine-2 in the Diagnosis and Prognosis of Sepsis

Szederjesi, János; Almasy, Emoke; Lazăr, Alexandra; Huţanu, Adina; Georgescu, Anca Meda

doi:10.1515/jccm-2015-0004

Cited by 5 publications

(6 citation statements)

References 17 publications

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“…The renal endothelium is identified as a rich source of Ang-2. Its release from the kidneys may increase due to kidney injury, for example, in the course of AP [ 2 , 14 , 22 , 23 ]. The correlations between Ang-2 and urea, creatinine, uNGAL, and albuminuria support the association of Ang-2 with kidney injury.…”

Section: Discussionmentioning

confidence: 99%

Angiopoietin-2 Is an Early Indicator of Acute Pancreatic-Renal Syndrome in Patients with Acute Pancreatitis

Sporek

Dumnicka

Gala-Błądzińska³

et al. 2016

Mediators of Inflammation

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Within the first week of the disease, acute kidney injury (AKI) is among the most common causes of mortality in acute pancreatitis (AP). Recently, serum angiopoietin-2 (Ang-2) has been associated with hyperdynamic state of the systemic circulation. The aim of this study was to examine the associations between Ang-2 and the clinical AP severity during the first 72 hours of the disease, and organ disfunction, including AKI. Methods. Study included patients admitted to the surgery ward, diagnosed with AP. AKI was diagnosed according to KDIGO guidelines and renal failure according to modified Marshall scoring system. Ang-2 was determined in serum with ELISA. Results. AP was classified as mild (MAP) in 71% of patients, moderately severe (MSAP) in 22%, and severe (SAP) in 8%. During the first 72 hours of AP, 11 patients developed AKI and 6 developed renal failure. Ang-2 at 24, 48, and 72 hours following the onset of AP symptoms significantly predicted SAP and MSAP, as well as AKI and renal failure. Also, Ang-2 significantly correlated with acute phase proteins as well as with the indicators of renal disfunction. Conclusions. Serum Ang-2 may be a relevant predictor of AP severity, in particular of the development of AP-renal syndrome.

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Section: Discussionmentioning

confidence: 99%

Angiopoietin-2 Is an Early Indicator of Acute Pancreatic-Renal Syndrome in Patients with Acute Pancreatitis

Sporek

Dumnicka

Gala-Błądzińska³

et al. 2016

Mediators of Inflammation

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“…Endothelial cell dysfunction constitutes the principal mechanism of the related processes which occur in sepsis (21). Ang-2 is a biomarker which is increased in septic patients and can be used for stratifying the severity of this condition (22). Literature describes associations between Ang-2/Tie-2 ratio in septic patients, with no certain diagnostic value in septic patients as well as other biomarkers with potential prognostic value, such as soluble urokinase-type plasminogen activator receptor (SuPAR) (23,16).…”

Section: Discussionmentioning

confidence: 99%

Genetic variability of ANG2-35G>C gene as a predictor factor in sepsis

Szederjesi

Lazăr

Petrișor

et al. 2020

Revista Romana De Medicina De Laborator

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To date it is unknown if there is a predisposition to sepsis. In this respect, genetic studies have been conducted with the aim to find gene variants which can point out a higher predisposition to developing sepsis. The primary objective of this study is to highlight whether the genetic polymorphism of Angiopoietin-2 gene (ANG2-35G>C) is present mainly in septic patients. As secondary objectives we aimed to evaluate if there are any associations between ANG2-35G>C polymorphism and the severity scores Acute Physiology and Chronic Health Evaluation II (APACHE II) and Simplified Acute Physiology Score (SAPS) as well as routine tests in septic patients such as C reactive protein (CRP), procalcitonin (PCT). We enrolled adult patients admitted to the Intensive Care Unit (ICU). After admission to the ICU and the diagnosis of sepsis, blood samples were collected and the severity scores: APACHE II, SAPS were calculated on the first day of ICU admission. We recorded the following from the blood samples: CRP, PCT, angiopoietine2 (Ang-2). We performed several one-way ANOVA tests to determine any significant mean difference of the analyzed variables. We observed that variant genotypes of ANG2-35G>C gene polymorphism are significantly related to CRP, aspect which increases this biomarker credibility compared with others (i.e., PCT), in septic patients. ANG2-35G>C gene polymorphism is associated with severity scores, APACHE II, and SAPS in sepsis.

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“…Increased plasma Ang-2 levels are reported in critically ill patients with sepsis and are associated with increased hospital mortality [17,18,19,20,21], as well as being correlated with the severity of illness [16,22].…”

Section: Introductionmentioning

confidence: 99%

“…Currently available evidence suggests that the Ang-2/Tie-2 ratio is changed in patients with sepsis [17], though more associated data on Ang-2/Tie-2 responses are required [16].…”

Section: Introductionmentioning

confidence: 99%

Ang-2, Tie-2, and Ang-2/Tie-2 ratio serum levels as diagnostic and prognostic biomarkers of sepsis in critically ill patients

Szederjesi

Georgescu

Santini

et al. 2016

Revista Romana De Medicina De Laborator

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Sepsis represents one the main cause of death in patients admitted to the intensive care. Biomarkers offer an alternative approach to the diagnostic and prognostic evaluation and improve the outcomes. Angiopoietin 2 (Ang-2)and Tyrosine kinase 2 07± 9,21 ng/ml), în comparație cu grupul B (6,18±5,28 ng/ml). Nivelele serice ale Tie-2 au fost de asemenea mai crescute pentru grupul A (11,03±5,12 ng/ml) comparativ cu grupul B (9,46±4,99 ng/ml) (p=0,19

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The Role of Angiopoietine-2 in the Diagnosis and Prognosis of Sepsis

Abstract: ANG-2 serum levels were elevated in sepsis, being well correlated with PCT values and prognostic scores. ANG-2 should be considered as a useful biomarker for the diagnosis and the prognosis of this pathology.

Cited by 5 publications

References 17 publications

Angiopoietin-2 Is an Early Indicator of Acute Pancreatic-Renal Syndrome in Patients with Acute Pancreatitis

Angiopoietin-2 Is an Early Indicator of Acute Pancreatic-Renal Syndrome in Patients with Acute Pancreatitis

Genetic variability of ANG2-35G>C gene as a predictor factor in sepsis

Ang-2, Tie-2, and Ang-2/Tie-2 ratio serum levels as diagnostic and prognostic biomarkers of sepsis in critically ill patients

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