The role of Andrographolide in the prevention and treatment of liver diseases

Qin, Xiaoyan; Wang, Xi; Tian, Maoying; Dong, Zhaowei; Wang, Jin; Wang, Chao; Huang, Qinwan

doi:10.1016/j.phymed.2022.154537

Cited by 10 publications

(3 citation statements)

References 127 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…While Andrographis paniculata (AP) contains various bioactive compounds with potential health benefits, 16 numerous studies have consistently identified andrographolide as the main bioactive constituent responsible for AP's therapeutic effects. 14,28 Andrographolide has garnered significant attention due to its extensively studied beneficial effects in various branches of medicine, 29,30,31 including cardiology. 14 Additionally, it has demonstrated some cardio-protective activities against DOX-induced cardiotoxicity in rats.…”

Section: Resultsmentioning

confidence: 99%

Evaluating the Acute Toxicity and In vivo Protective Effect of Standardized Andrographis paniculata Extract against Doxorubicin-induced Cardiotoxicity in Sprague-dawley Rats

2024

TJNPR

View full text Add to dashboard Cite

It is well-known and efficacious in treating several cancer types including ovarian, breast, thyroid, lung, gastric cancers, and pediatric cancers. 6 However, the consequence of its use is mainly cardiotoxicity. The frequency of DOX-induced cardiotoxicity, which varies with the dose and length of therapy along with the patient's age, sex, and preexisting cardiovascular problems, has been described in investigations. 7 DOX-induced cardiotoxicity remains a challenge in the field of oncology because of the increased risk of mortality in patients. 4,7 Researchers in the field of oncology have dedicated years of relentless effort to the pursuit of a ground breaking treatment for DOX-induced cardiotoxicity. The introduction of conventional drugs, including dexrazoxane, beta-blockers, angiotensin-converting enzyme inhibitors/angiotensin II receptor blockers (ACEI/ARB), and statins, represented an initial advancement in managing DOX-induced cardiotoxicity. However, these drugs exhibited limitations and failed to substantially improve the life expectancy of affected patients. [8][9][10][11][12] The limitations of current treatment options necessitate an ongoing search for alternative approaches to effectively manage DOX-induced cardiotoxicity. Herbal plants have shown promising potential and are being extensively investigated. 13 Andrographis paniculata (AP) is an herbal plant and a member of the Acanthaceae family, locally referred to as "sambiloto" in Indonesia. 14 It has been used extensively as an herbal medicine in many parts of Asia including China, the Philippines,

show abstract

Section: Resultsmentioning

confidence: 99%

Evaluating the Acute Toxicity and In vivo Protective Effect of Standardized Andrographis paniculata Extract against Doxorubicin-induced Cardiotoxicity in Sprague-dawley Rats

2024

TJNPR

View full text Add to dashboard Cite

show abstract

“…Pharmacological studies have found that Andrographis paniculata (Burm. f.) Nees and its active ingredients effectively prevent cardiovascular diseases through actions preventing myocardial ischaemia, protection of vascular endothelial cells, regulation of lipid and blood pressure and anti-atherosclerosis effects (Han et al, 2023;Huang et al, 2020;Komaikul et al, 2023;Qin et al, 2023). Our previous study showed the significant inhibitory effect of andrographolide (AGP) on aortic valve calcification (Wang, Huang, et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Andrographolide regulates H3 histone lactylation by interfering with p300 to alleviate aortic valve calcification

Wang,

Wang

et al. 2024

British J Pharmacology

View full text Add to dashboard Cite

Background and PurposeOur previous studies have found that andrographolide (AGP) alleviates calcific aortic valve disease (CAVD), but the underlying mechanism is unclear. This study explores the molecular target and signal mechanisms of AGP in inhibiting CAVD.Experimental ApproachThe anti‐calcification effects of the aortic valve with AGP treatment were evaluated by alizarin red staining in vitro and ultrasound and histopathological assessment of a high‐fat (HF)‐fed ApoE−/− mouse valve calcification model. A correlation between the H3 histone lactylation (H3Kla) and calcification was detected. Molecular docking and surface plasmon resonance (SPR) experiments were further used to confirm p300 as a target for AGP. Overexpression (oe) and silencing (si) of p300 were used to verify the inhibitory effect of AGP targeting p300 on the H3Kla in vitro and ex vivo.Key ResultsAGP significantly inhibited calcium deposition in valve interstitial cells (VICs) and ameliorated aortic valve calcification. The multi‐omics analysis revealed the glycolysis pathway involved in CAVD, indicating that AGP interfered with lactate production by regulating lactate dehydrogenase A (LDHA). In addition, lactylation, a new post‐translational modification, was shown to have a role in promoting aortic valve calcification. Furthermore, H3Kla and H3K9la site were shown to correlate with Runx2 expression inhibition by AGP treatment. Importantly, we found that p300 transferase was the molecular target of AGP in inhibiting H3Kla.Conclusions and ImplicationsOur findings, for the first time, demonstrated that AGP alleviates calcification by interfering with H3Kla via p300, which might be a powerful drug to prevent CAVD.

show abstract

“…The most common cause of liver cancer is infection with the hepatitis virus; other important risk factors include obesity, diabetes, alcohol usage, and aflatoxin ( Sayiner et al, 2019 ). Ninety percent of liver cancer cases are attributed to hepatocellular carcinoma (HCC), which is the predominant kind of liver cancer ( Qin et al, 2023 ). Currently, surgical resection, chemotherapy, liver transplantation, percutaneous ablation, transarterial chemoembolization, and transarterial radioembolization are the main treatments for HCC ( Chen et al, 2023 ).…”

Section: Introductionmentioning

confidence: 99%

Animal-derived natural products for hepatocellular carcinoma therapy: current evidence and future perspectives

Liao,

Wei,

et al. 2024

Front. Pharmacol.

View full text Add to dashboard Cite

Hepatocellular carcinoma (HCC) has a high morbidity and mortality rate, and the survival rate of HCC patients remains low. Animal medicines have been used as potential therapeutic tools throughout the long history due to their different structures of biologically active substances with high affinity to the human body. Here, we focus on the effects and the mechanism of action of animal-derived natural products against HCC, which were searched in databases encompassing Web of Science, PubMed, Embase, Science Direct, Springer Link, and EBSCO. A total of 24 natural products from 12 animals were summarized. Our study found that these natural products have potent anti-hepatocellular carcinoma effects. The mechanism of action involving apoptosis induction, autophagy induction, anti-proliferation, anti-migration, and anti-drug resistance via phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR), Ras/extracellular signal regulated kinases (ERK)/mitogen-activated protein kinase (MAPK), Wnt/β-catenin, and Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathways. Huachansu injection and sodium cantharidate have been used in clinical applications with good efficacy. We review the potential of animal-derived natural products and their derivatives in the treatment of HCC to date and summarize their application prospect and toxic side effects, hoping to provide a reference for drug development for HCC.

show abstract

The role of Andrographolide in the prevention and treatment of liver diseases

Cited by 10 publications

References 127 publications

Evaluating the Acute Toxicity and In vivo Protective Effect of Standardized Andrographis paniculata Extract against Doxorubicin-induced Cardiotoxicity in Sprague-dawley Rats

Evaluating the Acute Toxicity and In vivo Protective Effect of Standardized Andrographis paniculata Extract against Doxorubicin-induced Cardiotoxicity in Sprague-dawley Rats

Andrographolide regulates H3 histone lactylation by interfering with p300 to alleviate aortic valve calcification

Animal-derived natural products for hepatocellular carcinoma therapy: current evidence and future perspectives

Contact Info

Product

Resources

About