The Role of Amygdala in Self-Conscious Emotions in a Patient With Acquired Bilateral Damage

Piretti, Luca; Pappaianni, Edoardo; Lunardelli, Alberta; Zorzenon, Irene; Ukmar, Maja; Pesavento, Valentina; Rumiati, Raffaella I.; Job, Remo; Grecucci, Alessandro

doi:10.3389/fnins.2020.00677

Cited by 14 publications

(18 citation statements)

References 65 publications

(77 reference statements)

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“…20 The amygdala contributes to the emotional and social behavioural processes. 21 It has been reported that patients with amygdala damage are impaired in recognizing facial expressions of negative emotions. 22 Functional MRI has shown that the amygdala responds differentially to fearful versus happy facial expressions, depending on attentional processes.…”

Section: Discussionmentioning

confidence: 99%

Neuropsychological implication in possible antibody-negative limbic encephalitis: a clinical case report

et al. 2022

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Autoimmune limbic encephalitis is an antibody-mediated brain inflammatory process, which typically involves the medial temporal lobe. Diagnosis requires the presence of antineuronal antibodies, but sometimes patients present clinical features of limbic encephalitis despite negative serology. Thus, the diagnosis of antibody-negative limbic encephalitis is difficult to make, and it must often rely largely on exclusion of other causes. This current case report describes a 28-year-old male that presented 2 months after the acute event with radiological changes typical of limbic encephalitis, but with no identifiable antibody and neuropsychological impairment. Antibody responses to neurotropic viruses and antibody-mediated encephalitis were negative in serum and cerebrospinal fluid. Magnetic resonance imaging showed signs of hyperintensity in the hippocampus bilaterally, amygdala and left pulvinar. The neuropsychological evaluation showed a deficit in emotional face recognition and severe autobiographical amnesia. Bilateral damage to the medial temporal lobe and hippocampus, including the amygdala, is associated with alterations in autobiographical memories. The neuropsychological impairment documented in this current case expands the range of clinical features of antibody-negative encephalitis and provides evidence that the memory deficit in this disorder is more extensive than was previously recognized.

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Section: Discussionmentioning

confidence: 99%

Neuropsychological implication in possible antibody-negative limbic encephalitis: a clinical case report

et al. 2022

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“…Moral emotions are crucial in regulating social interactions, as they promote the welfare of the society or of other people (Haidt et al, 2003). Indeed, they provide the emotional drive to properly behave in social interactions (Kroll and Egan, 2004;Piretti et al, 2020;Grecucci et al, 2021), forcing individuals to implement strategies that are optimal over a long period, even though they do not appear functional in the short period (Ridley, 1996;Sober and Wilson, 1998).…”

Section: Introductionmentioning

confidence: 99%

The Neural Signatures of Shame, Embarrassment and Guilt: A Voxel-based Meta-analysis on Functional Neuroimaging Studies

Piretti¹,

Pappaianni²,

Garbin³

et al. 2023

Preprint

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Self-conscious emotions, such as shame and guilt, play a fundamental role in regulating moral behavior and in promoting the welfare of the society. Despite their relevance, the neural bases of these emotions are uncertain. In the present meta-analysis, we performed a systematic literature review in order to single out functional neuroimaging studies on healthy individuals specifically investigating the neural substrates of shame, embarrassment and guilt. Seventeen studies investigating the neural correlates of shame/embarrassment, and seventeen studies investigating guilt brain representation met our inclusion criteria. The analyses revealed that both guilt and shame/embarrassment were associated with the activation of the left anterior insula, involved in emotional awareness processing, and arousal. Guilt specific areas were located within the left temporo-parietal junction, which is thought to be involved in social cognitive processes. Moreover, specific activations for shame/embarrassment involved areas related to social pain (dorsal anterior cingulate, insula, thalamus), behavioral inhibition (premotor cortex) networks. This pattern of results might reflect distinct action tendencies associated with the two emotions.

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“…Numerous neuroimaging studies have explored BPD features in recent years, leading to the identification of some cerebral structural and functional alterations associated with the pathogenesis of BPD. Up to 2013, the majority of studies indicated that structural differences in the amygdala hub, hippocampus and cingulate cortex are involved in affective deficits ( Minzenberg et al, 2008 ; Nunes et al, 2009 ; Ruocco et al, 2012 ; Piretti et al, 2020 ). More recently, alterations in frontal (e.g., orbifrontal cortex, medial prefrontal cortex; Aguilar-Ortiz et al, 2018 ), cortical and subcortical regions ( Ruocco et al, 2016 ; Stanley et al, 2018 ; Davies et al, 2020 ; Lapomarda et al, 2021a , b ) have also been identified.…”

Section: Introductionmentioning

confidence: 99%

Structural Features Predict Sexual Trauma and Interpersonal Problems in Borderline Personality Disorder but Not in Controls: A Multi-Voxel Pattern Analysis

Dadomo

Lapomarda

Çiftçi

et al. 2022

Front. Hum. Neurosci.

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Child trauma plays an important role in the etiology of Bordeline Personality Disorder (BPD). Of all traumas, sexual trauma is the most common, severe and most associated with receiving a BPD diagnosis when adult. Etiologic models posit sexual abuse as a prognostic factor in BPD. Here we apply machine learning using Multiple Kernel Regression to the Magnetic Resonance Structural Images of 20 BPD and 13 healthy control (HC) to see whether their brain predicts five sources of traumas: sex abuse, emotion neglect, emotional abuse, physical neglect, physical abuse (Child Trauma Questionnaire; CTQ). We also applied the same analysis to predict symptom severity in five domains: affective, cognitive, impulsivity, interpersonal (Zanarini Rating Scale for Borderline Personality Disorder; Zan-BPD) for BPD patients only. Results indicate that CTQ sexual trauma is predicted by a set of areas including the amygdala, the Heschl area, the Caudate, the Putamen, and portions of the Cerebellum in BPD patients only. Importantly, interpersonal problems only in BPD patients were predicted by a set of areas including temporal lobe and cerebellar regions. Notably, sexual trauma and interpersonal problems were not predicted by structural features in matched healthy controls. This finding may help elucidate the brain circuit affected by traumatic experiences and connected with interpersonal problems BPD suffer from.

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The Role of Amygdala in Self-Conscious Emotions in a Patient With Acquired Bilateral Damage

Cited by 14 publications

References 65 publications

Neuropsychological implication in possible antibody-negative limbic encephalitis: a clinical case report

Neuropsychological implication in possible antibody-negative limbic encephalitis: a clinical case report

The Neural Signatures of Shame, Embarrassment and Guilt: A Voxel-based Meta-analysis on Functional Neuroimaging Studies

Structural Features Predict Sexual Trauma and Interpersonal Problems in Borderline Personality Disorder but Not in Controls: A Multi-Voxel Pattern Analysis

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