The role of amino acid metabolism alterations in pancreatic cancer: From mechanism to application

Fu, Shenao; Xu, Shaokang; Zhang, Shubing

doi:10.1016/j.bbcan.2023.188893

Cited by 10 publications

(5 citation statements)

References 132 publications

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“…A combination of IDO1 inhibitors and PD-1 inhibitors could enhance the response to immunotherapy. 110 Phosphoglycerate dehydrogenase (PHGDH) is a key enzyme for serine synthesis, which supplies substrate to synthesize Gly, a raw material for GSH. Inhibition of PHGDH promoted ferroptosis and suppressed tumor progression of bladder cancer.…”

Section: Discussionmentioning

confidence: 99%

“…IDO1, converting tryptophan to kynurenine, could cause an immunosuppressive microenvironment. A combination of IDO1 inhibitors and PD‐1 inhibitors could enhance the response to immunotherapy 110 . Phosphoglycerate dehydrogenase (PHGDH) is a key enzyme for serine synthesis, which supplies substrate to synthesize Gly, a raw material for GSH.…”

Section: Discussionmentioning

confidence: 99%

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Amino acids and their roles in tumor immunotherapy of breast cancer

Xia,

Zhu,

Zheng

et al. 2023

The Journal of Gene Medicine

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Breast cancer is the most commonly diagnosed cancer among women. The primary treatment options include surgery, radiotherapy, chemotherapy, targeted therapy and hormone therapy. The effectiveness of breast cancer therapy varies depending on the stage and aggressiveness of the cancer, as well as individual factors. Advances in early detection and improved treatments have significantly increased survival rates for breast cancer patients. Nevertheless, specific subtypes of breast cancer, particularly triple‐negative breast cancer, still lack effective treatment strategies. Thus, novel and effective therapeutic targets for breast cancer need to be explored. As substrates of protein synthesis, amino acids are important sources of energy and nutrition, only secondly to glucose. The rich supply of amino acids enables the tumor to maintain its proliferative competence through participation in energy generation, nucleoside synthesis and maintenance of cellular redox balance. Amino acids also play an important role in immune‐suppressive microenvironment formation. Thus, the biological effects of amino acids may change unexpectedly in tumor‐specific or oncogene‐dependent manners. In recent years, there has been significant progress in the study of amino acid metabolism, particularly in their potential application as therapeutic targets in breast cancer. In this review, we provide an update on amino acid metabolism and discuss the therapeutic implications of amino acids in breast cancer.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Amino acids and their roles in tumor immunotherapy of breast cancer

Xia,

Zhu,

Zheng

et al. 2023

The Journal of Gene Medicine

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“…Many studies have demonstrated that different types of cancer may have distinct amino acid biomarkers and that differences in the amount of amino acids in body uids and tissues are essential for both cancer diagnosis and treatment plan selection. [1][2][3] Saliva is one of the most suitable bodily uids for amino acid analysis. [4][5][6][7][8][9][10][11][12] Salivary amino acid proling has immense potential as a non-invasive diagnostic technique in cancer research.…”

Section: Introductionmentioning

confidence: 99%

Development and validation of a non-invasive method for quantifying amino acids in human saliva

Hasan,

Razu,

Akter

et al. 2024

RSC Adv.

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“…A number of studies have shown that amino acids used as potential biomarkers vary for different types of cancer, and changes in the concentration of amino acids in body fluids and tissues are important for diagnosing cancer, as well as choosing treatment tactics [ 8 , 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Diagnostic Value of Salivary Amino Acid Levels in Cancer

2023

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This review analyzed 21 scientific papers on the determination of amino acids in various types of cancer in saliva. Most of the studies are on oral cancer (8/21), breast cancer (4/21), gastric cancer (3/21), lung cancer (2/21), glioblastoma (2/21) and one study on colorectal, pancreatic, thyroid and liver cancer. The amino acids alanine, valine, phenylalanine, leucine and isoleucine play a leading role in the diagnosis of cancer via the saliva. In an independent version, amino acids are rarely used; the authors combine either amino acids with each other or with other metabolites, which makes it possible to obtain high values of sensitivity and specificity. Nevertheless, a logical and complete substantiation of the changes in saliva occurring in cancer, including changes in salivary amino acid levels, has not yet been formed, which makes it important to continue research in this direction.

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The role of amino acid metabolism alterations in pancreatic cancer: From mechanism to application

Cited by 10 publications

References 132 publications

Amino acids and their roles in tumor immunotherapy of breast cancer

Amino acids and their roles in tumor immunotherapy of breast cancer

Development and validation of a non-invasive method for quantifying amino acids in human saliva

Diagnostic Value of Salivary Amino Acid Levels in Cancer

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