The role of alternative polyadenylation in Epithelial-mesenchymal transition of non-small cell lung cancer
Sijia Wu,
Xinyu Qin,
Liyu Huang
Abstract:The metastatic non-small cell lung cancer (NSCLC) is one of the cancers with high incidence, poor survival, and limited treatment. Epithelial-mesenchymal transition (EMT) is the first step by which an early tumor converts to an invasive one. Studying the underlying mechanisms of EMT can help the understanding of cancer metastasis and improve the treatment. In this study, 1,013 NSCLC patients and 123 NSCLC cell lines are deeply analyzed for the potential roles of alternative polyadenylation (APA) in the EMT pro… Show more
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