The role of altered long noncoding RNAs in overall survival of ovarian cancer: A systematic review and meta-analysis

Hosseini, Elahe Seyed; Zarei, Marziyeh Alizadeh; Kashani, Hamed Haddad; Milajerdi, Alireza; Dehghanani, Zahra Zare; Bafrani, Hassan Hassani

doi:10.1016/j.prp.2021.153363

Cited by 3 publications

(1 citation statement)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous meta-analysis has showed that high lncRNAs expression could be used as potential prognostic markers among Asian bladder cancer patients [ 10 ]. Also dysregulation of lncRNAs expression were significantly associated with clinicopathology and survival of breast cancer patients [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

The impact of LncRNA dysregulation on clinicopathology and survival of pancreatic cancer: a systematic review and meta-analysis (PRISMA compliant)

et al. 2021

Self Cite

View full text Add to dashboard Cite

Purpose An increasing number of studies have reported a significant association between long non-coding RNAs (lncRNAs) dysregulation and pancreatic cancers. In the present study, we aimed to gather articles to evaluate the prognostic value of long non coding RNA in pancreatic cancer. Experimental design We systematically searched all eligible articles from databases of PubMed, Web of Science, and Scopus to meta-analysis of published articles and screen association of multiple lncRNAs expression with clinicopathology and/or survival of pancreatic cancer. The pooled hazard ratios (HRs) and their 95% confidence intervals (95% CIs) were used to analysis of overall survival, disease-free survival and progression-free survival were measured with a fixed or random effects model. Results A total of 39 articles were included in the present meta-analysis. Our results showed that dysregulation of lncRNAs were linked to overall survival (39 studies, 4736 patients HR = 0.41, 95% CI 0.25 ± 0.58, random-effects in pancreatic cancer. Moreover, altered lncRNAs were also contributed to progression-free survival (8 studies, 1180 patients HR: 1.88, 95% CI (1.35–2.62) and disease-free survival (2 studies, 285 patients, HR: 6.07, 95% CI 1.28–28.78). In addition, our findings revealed the association between dysregulated RNAs and clinicopathological features in this type of cancer. Conclusions In conclusion, dysregulated lncRNAs could be served as promising biomarkers for diagnosis and prognosis of pancreatic cancer.

show abstract

Section: Introductionmentioning

confidence: 99%

The impact of LncRNA dysregulation on clinicopathology and survival of pancreatic cancer: a systematic review and meta-analysis (PRISMA compliant)

et al. 2021

Self Cite

View full text Add to dashboard Cite

show abstract

Prognostic significance of non-coding RNAs related to the tumorigenic epithelial-mesenchymal transition (EMT) process among ovarian cancer patients: A systematic review and meta-analysis

Soltani Khaboushan,

Salimian,

Mehraban

et al. 2024

Heliyon

View full text Add to dashboard Cite

Insight on Non-Coding RNAs from Biofluids in Ovarian Tumors

Dabi

Favier

Razakamanantsoa

et al. 2023

Cancers

View full text Add to dashboard Cite

Ovarian tumors are the most frequent adnexal mass, raising diagnostic and therapeutic issues linked to a large spectrum of tumors, with a continuum from benign to malignant. Thus far, none of the available diagnostic tools have proven efficient in deciding strategy, and no consensus exists on the best strategy between “single test”, “dual testing”, “sequential testing”, “multiple testing options” and “no testing”. In addition, there is a need for prognostic tools such as biological markers of recurrence and theragnostic tools to detect women not responding to chemotherapy in order to adapt therapies. Non-coding RNAs are classified as small or long based on their nucleotide count. Non-coding RNAs have multiple biological functions such as a role in tumorigenesis, gene regulation and genome protection. These ncRNAs emerge as new potential tools to differentiate benign from malignant tumors and to evaluate prognostic and theragnostic factors. In the specific setting of ovarian tumors, the goal of the present work is to offer an insight into the contribution of biofluid non-coding RNAs (ncRNA) expression.

show abstract

The role of altered long noncoding RNAs in overall survival of ovarian cancer: A systematic review and meta-analysis

Cited by 3 publications

References 51 publications

The impact of LncRNA dysregulation on clinicopathology and survival of pancreatic cancer: a systematic review and meta-analysis (PRISMA compliant)

The impact of LncRNA dysregulation on clinicopathology and survival of pancreatic cancer: a systematic review and meta-analysis (PRISMA compliant)

Prognostic significance of non-coding RNAs related to the tumorigenic epithelial-mesenchymal transition (EMT) process among ovarian cancer patients: A systematic review and meta-analysis

Insight on Non-Coding RNAs from Biofluids in Ovarian Tumors

Contact Info

Product

Resources

About