The role of altered brain structural connectivity in resilience, vulnerability, and disease expression to schizophrenia

Wei, Qian; Zhao, Ling; Zou, Yan; Wang, Junjing; Qiu, Yong; Niu, Meiqi; Kang, Zhuang; Liu, Xiaojin; Tang, Yanxia; Li, Changhong; Zhang, Jinbei; Fan, Xiaoduo; Huang, Ruiwang; Han, Zili

doi:10.1016/j.pnpbp.2020.109917

Cited by 9 publications

(2 citation statements)

References 77 publications

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“…Functional activity and connectivity in DMN is critically involved in whether individuals develop PTSD after trauma [ 100 ]. Increased structural and functional connectivity of DMN is a key feature differentiating disease expression and resilience between patients and their unaffected siblings in bipolar disorder [ 32 ], alcohol use disorder [ 101 ] and schizophrenia [ 102 , 103 ]; DMN connectivity can be considered a protective feature that marks resilience [ 32 , 102 ]. The present study extends this concept to protection against vicarious traumatization through enhanced capacity to cope with traumatic exposure via media [ 99 ].…”

Section: Discussionmentioning

confidence: 99%

Psychological resilience mediates the protective role of default-mode network functional connectivity against COVID-19 vicarious traumatization

et al. 2023

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Vicarious traumatization (VT), a negative reaction to witnessing others’ trauma, has been experienced by some people during the COVID-19 pandemic, and can lead to mental health problems. This study aimed to identify functional brain markers of COVID-specific VT and explore the psychological mechanism underlying the brain-VT link. One hundred healthy participants underwent resting-state functional magnetic resonance imaging before the pandemic (October 2019–January 2020) and completed VT measurement during the pandemic (February–April 2020). Whole-brain correlation analysis based on global functional connectivity density (FCD) mapping revealed that VT was negatively correlated with FCD in the right inferior temporal gyrus (ITG) (i.e., the lower FCD in ITG, the worse the VT), identified by mapping onto known large-scale networks as part of the default-mode network (DMN). Resting-state functional connectivity (RSFC) analysis using ITG as seed found that VT was predicted by lower functional connectivity between ITG and other DMN regions including left medial prefrontal cortex, left orbitofrontal cortex, right superior frontal gyrus, right inferior parietal lobule and bilateral precuneus (i.e., the lower the ITG-DMN connectivity, the worse the VT). Mediation analyses suggested that psychological resilience served as a mediator in these associations of ITG FCD and ITG-DMN RSFC with VT. Our results provide novel evidence on the brain basis of VT and emphasize psychological resilience as an important link from DMN functional connectivity to COVID-specific-VT. This may facilitate public health interventions by helping identify individuals at risk of stress- and trauma-related psychopathologies.

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Section: Discussionmentioning

confidence: 99%

Psychological resilience mediates the protective role of default-mode network functional connectivity against COVID-19 vicarious traumatization

et al. 2023

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“…This observation aligns with the regional vulnerability hypothesis, which posits that local features such as cellular composition 21 , neurotransmitter receptors 22 , glutamatergic metabolism 23 , and gene expression 24 may play a crucial role in the pathophysiology and symptomatology of psychiatric conditions 25 . Within this context of localized susceptibility, recent research has explored the role that brain network dynamics plays in the progression of glioblastoma multiforme 26 ; or the influence of network connectivity on vulnerability, resilience, and expression to the onset of SCZ 27 . For example, excessive glutamatergic neurotransmission could lead to excitotoxic cellular damage and death 28 , potentially resulting in GM volume reduction 29 .…”

Section: Introductionmentioning

confidence: 99%

Molecular and micro-architectural mapping of gray matter alterations in psychosis

Garcia-San-Martin,

Bethlehem,

Mihalik

et al. 2023

Preprint

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The psychosis spectrum encompasses a heterogeneous range of clinical conditions associated with abnormal brain development. The molecular and micro-architectural attributes that account for structural deviations from typical neurodevelopment are still unknown. Here, we aggregate magnetic resonance imaging data from 38,696 healthy controls and 1,256 psychosis-related cases, including first-degree relatives, psychotic experiences, first-episodes, and chronic conditions. Using normative modeling, we generated centile scores for cortical gray matter phenotypes, identifying deviations in regional volumes below the expected trajectory for all conditions. Additionally, we mapped 46 neurobiological features from healthy individuals (including neurotransmitters, cell types, layer thickness, microstructure, cortical expansion, and metabolism) to these centiles using a multivariate approach. Results revealed that neurobiological features were highly co-localized with centile deviations, where metabolism and neurotransmitter concentrations showed the most consistent spatial overlap with abnormal developmental trajectories. These findings shed light on the vulnerability factors that may underlie atypical brain maturation during different stages of psychosis.

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Negative symptoms are associated with modularity and thalamic connectivity in schizophrenia

Bayrakçı

Zorlu

Karakılıç

et al. 2022

Eur Arch Psychiatry Clin Neurosci

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The role of altered brain structural connectivity in resilience, vulnerability, and disease expression to schizophrenia

Cited by 9 publications

References 77 publications

Psychological resilience mediates the protective role of default-mode network functional connectivity against COVID-19 vicarious traumatization

Psychological resilience mediates the protective role of default-mode network functional connectivity against COVID-19 vicarious traumatization

Molecular and micro-architectural mapping of gray matter alterations in psychosis

Negative symptoms are associated with modularity and thalamic connectivity in schizophrenia

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