The Role of Alkaloids in the Management of Diabetes Mellitus

Aloko, Sinmisola; Bello, Manuel O.

doi:10.1007/978-981-15-8791-7_15

Cited by 2 publications

(2 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The high levels of alkaloids, phenols, flavonoids and terpenoids in this study strongly suggest that CFAE could be a potential source of natural products, which could serve as effective free radical scavengers and/or inhibitors; hence could be a good plant-based pharmaceutical product for management of several diseases caused by free radicals. This is in line with several reports which highlighted the therapeutic effects of the above-mentioned phytochemicals (Adamski et al, 2020;Aloko and Bello, 2021). Steroids found in plants play critical roles in some ailments including prostate cancer (Lubik et al, 2016).…”

Section: Discussionsupporting

confidence: 88%

Phytochemical Compositions and Antioxidant Properties of Combined Funtumia africana and Abutilon mauritianum Extract (CFAE)

Uroko

Chukwu²,

Aaron³

et al. 2022

BIOMEDNATPROCH

View full text Add to dashboard Cite

Medically active compounds in plants confer biological effects including antioxidant properties. This study evaluated the phytochemical content and in vitro antioxidant properties of combined Funtumia africana leaves and Abutilon mauritianum extract (CFAE). The 1,1-diphenyl-2-picrylhydrazyl (DPPH), ferric reducing antioxidant power (FRAP), thiobarbituric acid reactive substances (TBARS), total antioxidant capacity (TAC), and nitric oxide radical (NO.) scavenging capabilities were used as antioxidant assay models. The results of the phytochemical analysis showed that CFAE is rich in alkaloids, flavonoids, tannins, saponins, phenols and cardiac glycosides. The extract contains antioxidant vitamins A, C and E, vitamin E being the most abundant. The CFAE showed a dose-dependent TAC based on the observed FRAP, TBARS, and DPPH scavenging activity which could be attributed to the presence of phenolic compounds and vitamins E. These strongly suggest that CFAE is a potential source of phytochemicals and antioxidants which could be exploited in the food and pharmaceutical industries in production of potent nutraceuticals or therapeutically-important products.

show abstract

Section: Discussionsupporting

confidence: 88%

Phytochemical Compositions and Antioxidant Properties of Combined Funtumia africana and Abutilon mauritianum Extract (CFAE)

Uroko

Chukwu²,

Aaron³

et al. 2022

BIOMEDNATPROCH

View full text Add to dashboard Cite

show abstract

“…Worldwide 800 herbs were reported to have strong antidiabetic potential, mainly by increased insulin secretion, α-glycosidase inhibitory activity, antiinflammatory effects, increased insulin resistance, regeneration of pancreatic β cells, and reduced diabetes-associated oxidative stress. Plenty of natural drugs mediate increased glucose uptake and suppression of hepatic glucose output by reducing glycogen degradation and gluconeogenesis, as well as glycolysis, glucose oxidation and glycogenesis [ 53 ]. It was determined that kaempferol improves hyperglycemia and also plays a beneficial role in diabetes by preventing oxidative damage in pancreatic β cells [ 54 ].…”

Section: Results and Discussion Antioxidant Activitymentioning

confidence: 99%

Comprehensive evaluation of Reseda lutea L. (Wild Mignonette) and 7 isolated flavonol glycosides: determination of antioxidant activity, anti-Alzheimer, antidiabetic and cytotoxic effects with in vitro and in silico methods

KIZILTAŞ¹

2022

Turkish Journal of Chemistry

View full text Add to dashboard Cite

In this study, anticholinergic, antidiabetic, antioxidant and cytotoxic activities of Reseda lutea L. ( R. lutea ) were determined. Ethanol extracts of R. lutea (EERL) and water extract of R. lutea (WERL) were prepared for biochemical analysis. The antioxidant capacities of EERL and WERL were evaluated with 6 different methods. In addition, acetylcholinesterase (AChE), α-amylase and α - glycosidase enzyme inhibition by EERL were measured. According to the results, EERL exhibited high inhibition effects against α-amylase, α-glycosidase and AChE enzymes. The IC 50 values of EERL against AChE (2.21 μg/mL), α-glycosidase (1.38 μg/mL), and α-amylase (0.11 μg/mL) were determined. Also, high cytotoxic effect of EERL was observed on human lung cancer cell lines (A549) with an IC 50 value of 3.58 ± 1.10 μg/mL. The affinities of 7 kaempferol and isorhamnetin rhamnopyranoside molecules, previously isolated from R. lutea , for AChE, α-amylase and, α-glycosidase were determined by molecular docking studies. Molecular docking results supported the in vitro results of the study. The results showed that the aerial parts of R. lutea have effective antioxidant, anticholinergic, antidiabetic and cytotoxic activities. This research will form the basis for further studies about R. lutea usage for drug development.

show abstract

The Role of Alkaloids in the Management of Diabetes Mellitus

Cited by 2 publications

References 31 publications

Phytochemical Compositions and Antioxidant Properties of Combined Funtumia africana and Abutilon mauritianum Extract (CFAE)

Phytochemical Compositions and Antioxidant Properties of Combined Funtumia africana and Abutilon mauritianum Extract (CFAE)

Comprehensive evaluation of Reseda lutea L. (Wild Mignonette) and 7 isolated flavonol glycosides: determination of antioxidant activity, anti-Alzheimer, antidiabetic and cytotoxic effects with in vitro and in silico methods

Contact Info

Product

Resources

About