The role of Algerian Ephedra alata ethanolic extract in inhibiting the growth of breast cancer cells by inducing apoptosis in a p53- dependent pathway

Bensam, Moufida; Rechreche, Hocine; Abdelwahab, Abeer E.; Abu‐Serie, Marwa M.; Ali, Safaa M.

doi:10.1016/j.sjbs.2023.103650

Cited by 5 publications

(4 citation statements)

References 57 publications

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“…Investigated the literature, we found a recent study has reported the anti-cancer property of ephedrine in TNBC cell lines, MDA-MB-231, and MCF-10. 70 , 71 Anti-cancer properties of other proposed compounds such as sorafenib and bicalutamide in TNBC is also supported by recent studies. 72 , 73 …”

Section: Discussionmentioning

confidence: 75%

Network-based approach elucidates critical genes in BRCA subtypes and chemotherapy response in triple negative breast cancer

Agrawal,

Jain,

Gopalan

et al. 2024

iScience

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Section: Discussionmentioning

confidence: 75%

Network-based approach elucidates critical genes in BRCA subtypes and chemotherapy response in triple negative breast cancer

Agrawal,

Jain,

Gopalan

et al. 2024

iScience

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“…58 Bensam et al also found that the ethanolic extract of Algerian E. alata aerial parts exhibited a good anticancer potential against MCF-7 cells (IC 50 = 153 µg/mL), HEPG2 cells (IC 50 = 359.43 µg/mL), and a human colon cancer cell line (IC 50 = 407.26 µg/mL). 12 The molecular analysis showed that four genes, Bax, p21, retinoblastoma protein, and tumor protein P53, were upregulated in MCF-7 cells treated either with the ethanolic extract of E. alata or the drug 5-fluorouracil. 12…”

Section: Anticancer Activitymentioning

confidence: 99%

“…2 Recently, many researchers have focused their studies on the species of Ephedra, and their isolated phytochemicals form an important basis for natural medications and nutrient complements. [4][5][6][7][8][9][10][11][12][13][14][15][16] Ephedra species (Ephedraceae family) are rich in alkaloids of the ephedrine type and act as sympathomimetics. 17 In general, Ephedra species have been traditionally used to treat bronchial asthma, chills, allergies, colds, coughs, edema, fever, flu, nasal congestion, and headaches.…”

Section: Introductionmentioning

confidence: 99%

Phytochemicals, Traditional Uses, Biological Effects, and Possible Molecular Mechanisms of Ephedra alata

Aidi Wannes,

Tounsi

2023

Future Integr Med

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Nowadays, Ephedra species have been marked as encouraging natural material for research in the field of pharmacology. This work provides an overview of the botanical, traditional uses, phytochemistry, pharmacological properties, molecular mechanisms, and toxicity of Ephedra alata. The following databases were utilized to search for primary literature references: PubMed, Web of Science, Scopus, Scientific Information Database, Science Direct, Google, and Google Scholar. The present review demonstrates that various compounds have been extracted from E. alata, such as fatty acids, sphingolipids, volatile compounds, reducing sugars, flavonoids, phenolic compounds, and alkaloids. These natural compounds show valuable biological activities, such as antioxidant, antimicrobial, anti-inflammatory, anticancer, antidiabetic, antihypertensive, anti-obesity, nephroprotective, hepatoprotective, antipyretic, analgesic, anti-acetylcholinesterase, antityrosinase, and anti-urease activities. Several mechanisms are proposed to understand the biological effects of E. alata. In summary, E. alata constitutes good natural material for utilization in food and medicine applications.

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“…The activity has been associated with the presence of diverse flavonoids, phenolic acids, and proanthocyanidins [37,[91][92][93]. A recent study evidenced the induction of tumor cell apoptosis in a p53-dependent manner by an ethanolic extract of E. alata (with a specimen from Algeria) [94]. Isoquercetin contributes to the anticancer effects in conjunction with other glycosylated flavonoids, such as luteolin-7-O-glucuronide and myricetin-3-rhamnoside, which have been characterized in a sample of a wild E. alata plant [40].…”

Section: Ephedra Alata Decnementioning

confidence: 99%

Ethnobotanical Uses and Pharmacological Activities of Moroccan Ephedra Species

Chroho,

Bailly,

Bouissane

2024

Planta Med

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Ephedra species are among the most popular herbs used in traditional medicine for a long time. The ancient Chinese medical book “Treatise on Febrile Diseases” refers to the classic traditional Chinese medicine prescription Ge Gen decoction, which consists of seven herbs, including an Ephedra species. Ephedra species are utilized all over the world to treat symptoms of the common cold and coughs, and to combat major human diseases, such as asthma, cancers, diabetes, cardiovascular and digestive disorders, and microbial infections. This study aimed at identifying specific Ephedra species used traditionally in Morocco for therapeutic purposes. The plant parts, their preparation process, and the treated pathologies were identified and analyzed. The results revealed five ethnobotanically important species of Ephedra: Ephedra alata Decne, Ephedra altissima Desf., Ephedra distachya L., Ephedra fragilis Desf., and Ephedra nebrodensis Tineo. These species are used traditionally in Morocco for treating people with diabetes, cancer, rheumatism, cold and asthma, hypertension, influenza virus infection, and respiratory ailments. In addition, they are occasionally used as calefacient agents, to regulate weight, or for capillary care. Few studies have underlined the antibacterial and antioxidant activities of some of these Moroccan Ephedra species, but little information is available regarding the natural products at the origin of the bioactivities. Further phytochemical investigations and clinical data are encouraged to better support the use of these plants.

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The role of Algerian Ephedra alata ethanolic extract in inhibiting the growth of breast cancer cells by inducing apoptosis in a p53- dependent pathway

Cited by 5 publications

References 57 publications

Network-based approach elucidates critical genes in BRCA subtypes and chemotherapy response in triple negative breast cancer

Network-based approach elucidates critical genes in BRCA subtypes and chemotherapy response in triple negative breast cancer

Phytochemicals, Traditional Uses, Biological Effects, and Possible Molecular Mechanisms of Ephedra alata

Ethnobotanical Uses and Pharmacological Activities of Moroccan Ephedra Species

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