The role of AGE–RAGE system in the development of diabetic nephropathy in vivo

Yamamoto, Yasuhiko; Kato, Ichiro; Doi, Toshio; Yonekura, Hideto; Ohashi, Seiji; Takeuchi, Masayoshi; Watanabe, Takeshi; Sakurai, Shigeru; Yasui, Kiyoshi; Petrova, Ralica G; Abedin, Md. Joynal; Li, Hui; Rahman, Afroza; Takasawa, Shin; Okamoto, Hiroshi; Yamamoto, Hiroshi

doi:10.1016/s0531-5131(02)00996-2

Cited by 5 publications

(3 citation statements)

References 18 publications

(17 reference statements)

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“…As shown in Figure 4 , the pathway enrichment analysis with ClueGO (a Cytoscape plugin) showed that key targets were mainly assigned to the AGE-RAGE and IL-17 signaling pathway. These pathways played a definite role in oxidative stress, glycolipid metabolism, inflammation, and renal fibrosis [ 38 – 40 ]. The typical targets of RC are regulated via a lot of pathways, such as DPP4, SOD1, ATK1, TGF- β 1, SphK1, RAGE, MAPK3, IL-6, PTK1, NOX4, TNF- α , and NF- κ B.…”

Section: Resultsmentioning

confidence: 99%

Radix Rehmanniae and Corni Fructus against Diabetic Nephropathy via AGE-RAGE Signaling Pathway

Chen

Shu

et al. 2020

Journal of Diabetes Research

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Background and Aims. Radix Rehmanniae and Corni Fructus (RC) have been widely applied to treat diabetic nephropathy (DN) for centuries. But the mechanism of how RC plays the therapeutic role against DN is unclear as yet. Methods. The information about RC was obtained from a public database. The active compounds of RC were screened by oral bioavailability (OB) and drug-likeness (DL). Gene ontology (GO) analysis was performed to realize the key targets of RC, and an active compound-potential target network was created. The therapeutic effects of RC active compounds and their key signal pathways were preliminarily probed via network pharmacology analysis and animal experiments. Results. In this study, 29 active compounds from RC and 64 key targets related to DN were collected using the network pharmacology method. The pathway enrichment analysis showed that RC regulated advanced glycosylation end product (AGE-) RAGE and IL-17 signaling pathways to treat DN. The animal experiments revealed that RC significantly improved metabolic parameters, inflammation renal structure, and function to protect the kidney against DN. Conclusions. The results revealed the relationship between multicomponents and multitargets of RC. The administratiom of RC might remit the DM-induced renal damage through the AGE-RAGE signaling pathway to improve metabolic parameters and protect renal structure and function.

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Section: Resultsmentioning

confidence: 99%

Radix Rehmanniae and Corni Fructus against Diabetic Nephropathy via AGE-RAGE Signaling Pathway

Chen

Shu

et al. 2020

Journal of Diabetes Research

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“…Receptors for AGEs were believed to play a critical role in AGEs related biology and the pathology associated with diabetic complications and aging disorders [44][45][46][47]. Some known popular receptors are: the RAGE [48], oligosaccharyl transferase-48 (AGE-R1) [49], galectin-3 (AGE-R3) [50], CD36 [51], and macrophage scavenger receptor types I and II [52].…”

Section: Effects Of Ages In Vivomentioning

confidence: 99%

“…Yamamoto et al [44] created transgenic mice that overexpress human RAGE in vascular cells, and crossbred them with another transgenic line which develops insulin-dependent diabetes early after birth. They found that the resultant double transgenic exhibited accelerated kidney changes compared with single transgenic littermales.…”

Section: Effects Of Ages In Vivomentioning

confidence: 99%

Toxicity of the AGEs generated from the Maillard reaction: On the relationship of food‐AGEs and biological‐AGEs

Nguyen

2006

Molecular Nutrition Food Res

191

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Advanced glycation end products (AGEs) are generated in the late stages of Maillard reaction in foods and biological systems. These products are mostly formed by the reactions of reducing sugar or degradation products of carbohydrates, lipids, and ascorbic acid. AGEs exist in high concentration in foods, but in relatively low concentrations in most of the biological systems. Recently, some AGEs have been reported to be toxic, and were proposed to be causative factors for various kinds of diseases, especially diabetes and kidney disorder, through the association with receptor of AGE (RAGE). It has also been reported that food-derived AGEs (food-AGEs) may not be a causative factor for pro-oxidation. However, the relationship of food-AGEs and biological-derived AGEs (biological-AGEs) is not clear. In this review, the following issues are discussed: the formation of AGEs in foods and biological systems; identification of the main AGEs in foods and biological systems; absorption of food-AGEs; the effects of AGEs in vivo; relationship between food-AGEs and biological-AGEs; possible defense mechanism against AGEs in vivo and finally, the problems to be solved concerning the toxicity of AGEs.

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