The role of affective temperaments assessed by the Temperament Evaluation of Memphis, Pisa and San Diego-Autoquestionnaire (TEMPS-A) in the relationship between morningness-eveningness and bipolarity

Chrobak, Adrian Andrzej; Tereszko, Anna; Dembińska-Krajewska, Daria; Arciszewska, Aleksandra; Dopierała, Ewa; Siwek, Marcin; Dudek, Dominika; Rybakowski, Janusz

doi:10.1016/j.jad.2018.02.017

Cited by 14 publications

(10 citation statements)

References 56 publications

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“…In a group of 302 individuals, evening-types displayed significant bipolarity or mood fluctuations [66]. Another study based on 1,449 web questionnaires also supported the conclusion that eveningness is associated with bipolarity [67].…”

Section: Chronotype and Bipolar Disordermentioning

confidence: 85%

Chronotypes and affective disorders: A clock for mood?

Gao

Shi

Qin

et al. 2019

Brain Science Advances

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Affective disorders are often accompanied by circadian rhythm disruption and the major symptoms of mental illness occur in a rhythmic manner. Chronotype, also known as circadian preference for rest or activity, is believed to exert a substantial influence on mental health. Here, we review the connection between chronotypes and affective disorders, and discuss the potential underlying mechanisms between these two phenomena.

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Section: Chronotype and Bipolar Disordermentioning

confidence: 85%

Chronotypes and affective disorders: A clock for mood?

Gao

Shi

Qin

et al. 2019

Brain Science Advances

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“…45 Irritable and cyclothymic traits fully mediated the relationship between chronotype and bipolarity, while depressive and anxious traits further increased the effect. 46 However, both of these studies were performed on a healthy population, which raises the question of whether the results can be replicated in a clinical sample.…”

Section: Discussionmentioning

confidence: 99%

Evening chronotype as a bipolar feature among patients with major depressive disorder: the results of a pilot factor analysis

Mokros

Nowakowska‐Domagała

Pietras

2022

Braz. J. Psychiatry

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Objectives: The bipolar spectrum concept has resulted in a paradigm shift that has affected both the diagnosis and therapy of mood disorders, with bipolarity becoming an indicator of treatment resistance in depression. Evening circadian preference has also been linked to affective disorders. The aim of our study was to confirm the relationship between the severity of depressive symptoms, bipolar features, chronotype, and sleep quality among patients with major depressive disorder. Methods: A group of 55 individuals who were recruited from a mental health outpatient clinic completed the following psychometric tools: a Chronotype Questionnaire comprising morningnesseveningness (ME) and subjective amplitude of the rhythm (AM) scales, the Hypomania Checklist 32 (HCL-32), the Beck Depression Inventory (BDI) and the Pittsburgh Sleep Quality Index (PSQI). Results: Factor analysis identified two latent components, accounting cumulatively for 58% of variables: depressive symptoms (BDI and PSQI) and bipolarity (ME, AM, and HCL-32). After rotation, ME loading in the first factor increased the result to a significant level. The correlation between the two components was very low. Conclusions: Evening chronotype appears to be a bipolarity-related marker, with this relationship being independent of its link to depressive symptoms and sleep quality. Eveningness and high circadian rhythm amplitude may offer promise as diagnostic, prognostic, and therapeutic predictors.

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“…Future studies making use of accelerometry and other wearable devices may be able to more precisely capture changes in circadian disruption as primary outcome measures in more precise terms of behavioral/physiological variables and allow for more comprehensive analyses of rhythms as they relate to mood symptoms. While others have previously examined the relationship of the TEMPS‐A to chronotype to reveal significant associations, 42 our use of the CDI is novel and has not yet been validated in other populations. In the cross‐sectional portion, LiM patients are likely overrepresented in Li‐Rs.…”

Section: Discussionmentioning

confidence: 99%

Correction of depression‐associated circadian rhythm abnormalities is associated with lithium response in bipolar disorder

et al. 2021

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Background Bipolar disorder (BD) is characterized by episodes of depression and mania and disrupted circadian rhythms. Lithium is an effective therapy for BD, but only 30%–40% of patients are fully responsive. Preclinical models show that lithium alters circadian rhythms. However, it is unknown if the circadian rhythm effects of lithium are essential to its therapeutic properties. Methods In secondary analyses of a multi‐center, prospective, trial of lithium for BD, we examined the relationship between circadian rhythms and therapeutic response to lithium. Using standardized instruments, we measured morningness, diurnal changes in mood, sleep, and energy (circadian rhythm disturbances) in a cross‐sectional study of 386 BD subjects with varying lithium exposure histories. Next, we tracked symptoms of depression and mania prospectively over 12 weeks in a subset of 88 BD patients initiating treatment with lithium. Total, circadian, and affective mood symptoms were scored separately and analyzed. Results Subjects with no prior lithium exposure had the most circadian disruption, while patients stable on lithium monotherapy had the least. Patients who were stable on lithium with another drug or unstable on lithium showed intermediate levels of disruption. Treatment with lithium for 12 weeks yielded significant reductions in total and affective depression symptoms. Lithium responders (Li‐Rs) showed improvement in circadian symptoms of depression, but non‐responders did not. There was no difference between Li‐Rs and nonresponders in affective, circadian, or total symptoms of mania. Conclusions Exposure to lithium is associated with reduced circadian disruption. Lithium response at 12 weeks was selectively associated with the reduction of circadian depressive symptoms. We conclude that stabilization of circadian rhythms may be an important feature of lithium's therapeutic effects. Clinical Trials Registry: NCT0127253.

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The role of affective temperaments assessed by the Temperament Evaluation of Memphis, Pisa and San Diego-Autoquestionnaire (TEMPS-A) in the relationship between morningness-eveningness and bipolarity

Cited by 14 publications

References 56 publications

Chronotypes and affective disorders: A clock for mood?

Chronotypes and affective disorders: A clock for mood?

Evening chronotype as a bipolar feature among patients with major depressive disorder: the results of a pilot factor analysis

Correction of depression‐associated circadian rhythm abnormalities is associated with lithium response in bipolar disorder

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